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ZNF217 zinc finger protein 217 [ Homo sapiens (human) ]

Gene ID: 7764, updated on 6-Sep-2022

Summary

Official Symbol
ZNF217provided by HGNC
Official Full Name
zinc finger protein 217provided by HGNC
Primary source
HGNC:HGNC:13009
See related
Ensembl:ENSG00000171940 MIM:602967; AllianceGenome:HGNC:13009
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZABC1
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in mitochondrion and nuclear speck. Part of histone deacetylase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in urinary bladder (RPKM 14.5), spleen (RPKM 14.3) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF217 in Genome Data Viewer
Location:
20q13.2
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (53567071..53597702, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (55339255..55366009, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (52183610..52210378, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene teashirt zinc finger homeobox 2 Neighboring gene uncharacterized LOC105372669 Neighboring gene uncharacterized LOC105372671 Neighboring gene uncharacterized LOC101927770 Neighboring gene uncharacterized LOC105372672 Neighboring gene RNA, U7 small nuclear 14 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of histone deacetylase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385034.1NP_001371963.1  zinc finger protein 217 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL157838
    UniProtKB/TrEMBL
    H0UI66
    Conserved Domains (7) summary
    PHA03247
    Location:750970
    PHA03247; large tegument protein UL36; Provisional
    COG5048
    Location:468733
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:130150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:473493
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:472493
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:485510
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:499523
    zf-H2C2_5; C2H2-type zinc-finger domain
  2. NM_006526.3NP_006517.1  zinc finger protein 217 isoform 2

    See identical proteins and their annotated locations for NP_006517.1

    Status: REVIEWED

    Source sequence(s)
    AL157838
    Consensus CDS
    CCDS13443.1
    UniProtKB/Swiss-Prot
    O75362, Q14DB8
    Related
    ENSP00000360526.2, ENST00000371471.7
    Conserved Domains (5) summary
    sd00017
    Location:130150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:473493
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:472493
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:485510
    zf-H2C2_2; Zinc-finger double domain
    cl26464
    Location:750938
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    53567071..53597702 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529036.2XP_011527338.1  zinc finger protein 217 isoform X1

    See identical proteins and their annotated locations for XP_011527338.1

    UniProtKB/TrEMBL
    H0UI66
    Conserved Domains (7) summary
    PHA03247
    Location:750970
    PHA03247; large tegument protein UL36; Provisional
    COG5048
    Location:468733
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:130150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:473493
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:472493
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:485510
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:499523
    zf-H2C2_5; C2H2-type zinc-finger domain
  2. XM_047440462.1XP_047296418.1  zinc finger protein 217 isoform X1

    UniProtKB/TrEMBL
    H0UI66
  3. XM_005260545.5XP_005260602.1  zinc finger protein 217 isoform X1

    See identical proteins and their annotated locations for XP_005260602.1

    UniProtKB/TrEMBL
    H0UI66
    Conserved Domains (7) summary
    PHA03247
    Location:750970
    PHA03247; large tegument protein UL36; Provisional
    COG5048
    Location:468733
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:130150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:473493
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:472493
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:485510
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:499523
    zf-H2C2_5; C2H2-type zinc-finger domain
  4. XM_047440459.1XP_047296415.1  zinc finger protein 217 isoform X1

    UniProtKB/TrEMBL
    H0UI66
  5. XM_024451997.2XP_024307765.1  zinc finger protein 217 isoform X1

    UniProtKB/TrEMBL
    H0UI66
    Conserved Domains (7) summary
    PHA03247
    Location:750970
    PHA03247; large tegument protein UL36; Provisional
    COG5048
    Location:468733
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:130150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:473493
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:472493
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:485510
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:499523
    zf-H2C2_5; C2H2-type zinc-finger domain
  6. XM_047440461.1XP_047296417.1  zinc finger protein 217 isoform X1

    UniProtKB/TrEMBL
    H0UI66
  7. XM_024451998.2XP_024307766.1  zinc finger protein 217 isoform X1

    UniProtKB/TrEMBL
    H0UI66
    Conserved Domains (7) summary
    PHA03247
    Location:750970
    PHA03247; large tegument protein UL36; Provisional
    COG5048
    Location:468733
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:130150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:473493
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:472493
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:485510
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:499523
    zf-H2C2_5; C2H2-type zinc-finger domain
  8. XM_047440460.1XP_047296416.1  zinc finger protein 217 isoform X1

    UniProtKB/TrEMBL
    H0UI66
  9. XM_047440464.1XP_047296420.1  zinc finger protein 217 isoform X2

    UniProtKB/Swiss-Prot
    Q14DB8
  10. XM_047440463.1XP_047296419.1  zinc finger protein 217 isoform X2

    UniProtKB/Swiss-Prot
    Q14DB8
  11. XM_047440465.1XP_047296421.1  zinc finger protein 217 isoform X2

    UniProtKB/Swiss-Prot
    Q14DB8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    55339255..55366009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)