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ZNF213 zinc finger protein 213 [ Homo sapiens (human) ]

Gene ID: 7760, updated on 1-Jun-2020

Summary

Official Symbol
ZNF213provided by HGNC
Official Full Name
zinc finger protein 213provided by HGNC
Primary source
HGNC:HGNC:13005
See related
Ensembl:ENSG00000085644 MIM:608387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CR53; ZSCAN53; ZKSCAN21
Summary
C2H2 zinc finger proteins, such as ZNF213, have bipartite structures in which one domain binds DNA or RNA and the other modulates target gene expression.[supplied by OMIM, Apr 2004]
Expression
Broad expression in testis (RPKM 12.1), ovary (RPKM 4.1) and 24 other tissues See more
Orthologs

Genomic context

See ZNF213 in Genome Data Viewer
Location:
16p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (3135029..3142804)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3185057..3192805)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ZNF205 antisense RNA 1 Neighboring gene zinc finger protein 205 Neighboring gene ZNF213 antisense RNA 1 (head to head) Neighboring gene caspase 16, pseudogene Neighboring gene tRNA-Arg (anticodon CCG) 1-3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 213
Names
putative transcription factor CR53
zinc finger protein with KRAB and SCAN domains 21

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134655.2NP_001128127.1  zinc finger protein 213

    See identical proteins and their annotated locations for NP_001128127.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate donor splice site at the first exon, hence has a different 5' UTR compared to variant 1. Transcript variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC108134, AK289834, AK291789, BC080572, BM974318, DA115503
    Consensus CDS
    CCDS10495.1
    UniProtKB/Swiss-Prot
    O14771
    UniProtKB/TrEMBL
    A0A0S2Z4L6
    Related
    ENSP00000459177.1, ENST00000576416.5
    Conserved Domains (4) summary
    smart00431
    Location:41145
    SCAN; leucine rich region
    cd07765
    Location:202237
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:315451
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:319339
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_004220.3NP_004211.1  zinc finger protein 213

    See identical proteins and their annotated locations for NP_004211.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the more predominant transcript. Transcript variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC108134, AK291789, BC080572, BM974318, DA811482
    Consensus CDS
    CCDS10495.1
    UniProtKB/Swiss-Prot
    O14771
    UniProtKB/TrEMBL
    A0A0S2Z4L6
    Related
    ENSP00000380087.3, ENST00000396878.8
    Conserved Domains (4) summary
    smart00431
    Location:41145
    SCAN; leucine rich region
    cd07765
    Location:202237
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:315451
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:319339
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_104432.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of an exon compare to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC108134, AK055337, BC116445, DA811482
    Related
    ENST00000576863.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    3135029..3142804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522652.3XP_011520954.1  zinc finger protein 213 isoform X1

    Conserved Domains (3) summary
    smart00431
    Location:41145
    SCAN; leucine rich region
    cd07765
    Location:202237
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    pfam02023
    Location:41127
    SCAN; SCAN domain
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