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Notum notum palmitoleoyl-protein carboxylesterase [ Mus musculus (house mouse) ]

Gene ID: 77583, updated on 31-Jan-2023

Summary

Official Symbol
Notumprovided by MGI
Official Full Name
notum palmitoleoyl-protein carboxylesteraseprovided by MGI
Primary source
MGI:MGI:1924833
See related
Ensembl:ENSMUSG00000042988 AllianceGenome:MGI:1924833
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730593N15Rik
Summary
Enables lipase activity and palmitoleyl hydrolase activity. Involved in negative regulation of Wnt signaling pathway and protein depalmitoleylation. Acts upstream of or within bone development; negative regulation of canonical Wnt signaling pathway; and regulation of bone mineralization. Predicted to be located in extracellular region. Is expressed in several structures, including genitourinary system; heart valve; respiratory system; sensory organ; and vibrissa. Orthologous to human NOTUM (notum, palmitoleoyl-protein carboxylesterase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 11.4), kidney adult (RPKM 4.2) and 10 other tissues See more
Orthologs
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Genomic context

See Notum in Genome Data Viewer
Location:
11; 11 E2
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120544614..120552019, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120653788..120661193, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 17586 Neighboring gene pyrroline-5-carboxylate reductase 1 Neighboring gene myeloid-associated differentiation marker-like 2 Neighboring gene alveolar soft part sarcoma chromosome region, candidate 1 (human) Neighboring gene centromere protein X

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables palmitoleyl hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables palmitoleyl hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
palmitoleoyl-protein carboxylesterase NOTUM
Names
notum pectinacetylesterase homolog
protein notum homolog
NP_001369198.1
NP_001369199.1
NP_780472.3
XP_006534560.1
XP_011247617.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382269.1NP_001369198.1  palmitoleoyl-protein carboxylesterase NOTUM isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL663030
    UniProtKB/Swiss-Prot
    A2ABZ6
    UniProtKB/TrEMBL
    A0A8C6I3W1
    Conserved Domains (1) summary
    pfam03283
    Location:88426
    PAE; Pectinacetylesterase
  2. NM_001382270.1NP_001369199.1  palmitoleoyl-protein carboxylesterase NOTUM isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL663030
    Conserved Domains (1) summary
    pfam03283
    Location:88242
    PAE; Pectinacetylesterase
  3. NM_001415776.1NP_001402705.1  palmitoleoyl-protein carboxylesterase NOTUM isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL663030
  4. NM_175263.4NP_780472.3  palmitoleoyl-protein carboxylesterase NOTUM isoform 1 precursor

    See identical proteins and their annotated locations for NP_780472.3

    Status: VALIDATED

    Source sequence(s)
    AI849590, AK019987, AL663030, DN174397
    Consensus CDS
    CCDS49007.1
    UniProtKB/Swiss-Prot
    A2ABZ6, Q8R116
    UniProtKB/TrEMBL
    A0A8C6I3W1
    Related
    ENSMUSP00000101784.3, ENSMUST00000106178.9
    Conserved Domains (1) summary
    pfam03283
    Location:88426
    PAE; Pectinacetylesterase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120544614..120552019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534497.4XP_006534560.1  palmitoleoyl-protein carboxylesterase NOTUM isoform X2

    Conserved Domains (1) summary
    pfam03283
    Location:123277
    PAE; Pectinacetylesterase
  2. XM_011249315.1XP_011247617.1  palmitoleoyl-protein carboxylesterase NOTUM isoform X1

    Conserved Domains (1) summary
    pfam03283
    Location:114424
    PAE; Pectinacetylesterase