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Mboat7 membrane bound O-acyltransferase domain containing 7 [ Mus musculus (house mouse) ]

Gene ID: 77582, updated on 5-Mar-2024

Summary

Official Symbol
Mboat7provided by MGI
Official Full Name
membrane bound O-acyltransferase domain containing 7provided by MGI
Primary source
MGI:MGI:1924832
See related
Ensembl:ENSMUSG00000035596 AllianceGenome:MGI:1924832
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BB1; Leng4; Lpiat; Lpiat1; LPLAT 7; m-mboa-7; 5730589L02Rik
Summary
Enables O-acyltransferase activity and lysophospholipid acyltransferase activity. Involved in phosphatidylinositol acyl-chain remodeling and regulation of triglyceride metabolic process. Acts upstream of or within layer formation in cerebral cortex; phosphatidylinositol metabolic process; and ventricular system development. Located in membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human MBOAT7 (membrane bound O-acyltransferase domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 41.2), ovary adult (RPKM 26.4) and 28 other tissues See more
Orthologs
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Genomic context

See Mboat7 in Genome Data Viewer
Location:
7 A1; 7 2.12 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3680788..3696188, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3677789..3693189, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CCR4-NOT transcription complex, subunit 3 Neighboring gene microRNA 3572 Neighboring gene STARR-positive B cell enhancer ABC_E1077 Neighboring gene leukocyte receptor cluster (LRC) member 1 Neighboring gene transmembrane channel-like gene family 4 Neighboring gene tRNA splicing endonuclease subunit 34 Neighboring gene STARR-positive B cell enhancer ABC_E2812 Neighboring gene ribosomal protein S9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables O-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables lysophospholipid acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables lysophospholipid acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondria-associated endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondria-associated endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
lysophospholipid acyltransferase 7
Names
1-acylglycerophosphatidylinositol O-acyltransferase
bladder and breast carcinoma-overexpressed gene 1 protein
leukocyte receptor cluster (LRC) member 4
lysophosphatidylinositol acyltransferase 1
membrane-bound O-acyltransferase domain-containing protein 7
NP_084210.2
XP_006540495.1
XP_006540496.1
XP_011249044.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029934.4NP_084210.2  lysophospholipid acyltransferase 7

    See identical proteins and their annotated locations for NP_084210.2

    Status: VALIDATED

    Source sequence(s)
    AC171680
    Consensus CDS
    CCDS20724.1
    UniProtKB/Swiss-Prot
    Q3UDM6, Q8CHK3, Q8R1P9, Q9CY76
    Related
    ENSMUSP00000037107.8, ENSMUST00000038608.14
    Conserved Domains (1) summary
    cl00738
    Location:8431
    MBOAT; membrane-bound O-acyltransferase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    3680788..3696188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540433.4XP_006540496.1  lysophospholipid acyltransferase 7 isoform X2

    See identical proteins and their annotated locations for XP_006540496.1

    Conserved Domains (1) summary
    cl00738
    Location:117408
    MBOAT; membrane-bound O-acyltransferase family
  2. XM_006540432.5XP_006540495.1  lysophospholipid acyltransferase 7 isoform X1

    See identical proteins and their annotated locations for XP_006540495.1

    UniProtKB/Swiss-Prot
    Q3UDM6, Q8CHK3, Q8R1P9, Q9CY76
    Conserved Domains (1) summary
    cl00738
    Location:8431
    MBOAT; membrane-bound O-acyltransferase family
  3. XM_011250742.3XP_011249044.1  lysophospholipid acyltransferase 7 isoform X2

    See identical proteins and their annotated locations for XP_011249044.1

    Conserved Domains (1) summary
    cl00738
    Location:117408
    MBOAT; membrane-bound O-acyltransferase family