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ZNF208 zinc finger protein 208 [ Homo sapiens (human) ]

Gene ID: 7757, updated on 23-Nov-2021

Summary

Official Symbol
ZNF208provided by HGNC
Official Full Name
zinc finger protein 208provided by HGNC
Primary source
HGNC:HGNC:12999
See related
Ensembl:ENSG00000160321 MIM:603977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PMIDP; ZNF95
Summary
Zinc finger proteins (ZNFs), such as ZNF208, bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. A conserved protein motif, termed the Kruppel-associated box (KRAB) domain, mediates protein-protein interactions (Eichler et al., 1998 [PubMed 9724325]). See ZNF91 (MIM 603971) for further information on ZNFs.[supplied by OMIM, Aug 2009]
Expression
Broad expression in thyroid (RPKM 2.0), testis (RPKM 1.5) and 23 other tissues See more
Orthologs
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Genomic context

See ZNF208 in Genome Data Viewer
Location:
19p12
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (21939815..22010943, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (22122617..22193745, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372326 Neighboring gene uncharacterized LOC112268249 Neighboring gene uncharacterized LOC105372325 Neighboring gene metadherin pseudogene 2 Neighboring gene BCL2 interacting protein 3 pseudogene 28 Neighboring gene uncharacterized LOC112268248 Neighboring gene zinc finger protein 257 Neighboring gene BCL2 interacting protein 3 pseudogene 29

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 208
Names
zinc finger protein 95

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329971.2NP_001316900.1  zinc finger protein 208 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC003973
  2. NM_001329972.1NP_001316901.1  zinc finger protein 208 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC003973
  3. NM_001329973.1NP_001316902.1  zinc finger protein 208 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC003973
  4. NM_001329974.2NP_001316903.1  zinc finger protein 208 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC003973
    Consensus CDS
    CCDS86734.1
    UniProtKB/TrEMBL
    M0QYK4
    Related
    ENSP00000469887.1, ENST00000601773.5
  5. NM_007153.3NP_009084.2  zinc finger protein 208 isoform 1

    See identical proteins and their annotated locations for NP_009084.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC003973
    Consensus CDS
    CCDS54240.1
    UniProtKB/Swiss-Prot
    O43345
    Related
    ENSP00000380315.3, ENST00000397126.9
    Conserved Domains (5) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    COG5048
    Location:6911133
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:667687
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:511536
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_138252.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC003973, BC038199, BX281273
    Related
    ENST00000597040.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    21939815..22010943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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