Format

Send to:

Choose Destination

ZMYM2 zinc finger MYM-type containing 2 [ Homo sapiens (human) ]

Gene ID: 7750, updated on 4-Oct-2020

Summary

Official Symbol
ZMYM2provided by HGNC
Official Full Name
zinc finger MYM-type containing 2provided by HGNC
Primary source
HGNC:HGNC:12989
See related
Ensembl:ENSG00000121741 MIM:602221
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FIM; MYM; RAMP; SCLL; ZNF198
Summary
The protein encoded by this gene is a zinc finger protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in testis (RPKM 14.1), thyroid (RPKM 6.8) and 25 other tissues See more
Orthologs

Genomic context

See ZMYM2 in Genome Data Viewer
Location:
13q12.11
Exon count:
35
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (19957423..20089115)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (20531708..20665968)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 pseudogene 1 Neighboring gene zinc finger MYM-type containing 5 Neighboring gene KRR1 pseudogene 1 Neighboring gene uncharacterized LOC105370101 Neighboring gene long intergenic non-protein coding RNA 1072

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
PML body IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
zinc finger MYM-type protein 2
Names
fused in myeloproliferative disorders protein
rearranged in an atypical myeloproliferative disorder
zinc finger protein 198
zinc finger, MYM-type 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023348.2 RefSeqGene

    Range
    5001..138176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001190964.4NP_001177893.1  zinc finger MYM-type protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001177893.1

    Status: REVIEWED

    Source sequence(s)
    AL137119, AL138688
    Consensus CDS
    CCDS45016.1
    UniProtKB/Swiss-Prot
    Q9UBW7
    UniProtKB/TrEMBL
    A0A024RDS3
    Related
    ENSP00000372327.2, ENST00000382874.6
    Conserved Domains (2) summary
    pfam06467
    Location:462502
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11921359
    DUF3504; Domain of unknown function (DUF3504)
  2. NM_001190965.4NP_001177894.1  zinc finger MYM-type protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001177894.1

    Status: REVIEWED

    Source sequence(s)
    AL137119, AL138688
    Consensus CDS
    CCDS45016.1
    UniProtKB/Swiss-Prot
    Q9UBW7
    UniProtKB/TrEMBL
    A0A024RDS3
    Conserved Domains (2) summary
    pfam06467
    Location:462502
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11921359
    DUF3504; Domain of unknown function (DUF3504)
  3. NM_001353157.2NP_001340086.1  zinc finger MYM-type protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL137119, AL138688
    Consensus CDS
    CCDS45016.1
    Conserved Domains (2) summary
    pfam06467
    Location:462502
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11921359
    DUF3504; Domain of unknown function (DUF3504)
  4. NM_001353159.2NP_001340088.1  zinc finger MYM-type protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL137119, AL138688
    Consensus CDS
    CCDS45016.1
    Conserved Domains (2) summary
    pfam06467
    Location:462502
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11921359
    DUF3504; Domain of unknown function (DUF3504)
  5. NM_001353161.3NP_001340090.1  zinc finger MYM-type protein 2 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL137119, AL138688
    Conserved Domains (2) summary
    pfam06467
    Location:397437
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11271294
    DUF3504; Domain of unknown function (DUF3504)
  6. NM_001353162.3NP_001340091.1  zinc finger MYM-type protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL137119, AL138688
    Consensus CDS
    CCDS45016.1
    Conserved Domains (2) summary
    pfam06467
    Location:462502
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11921359
    DUF3504; Domain of unknown function (DUF3504)
  7. NM_001353163.2NP_001340092.1  zinc finger MYM-type protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL137119, AL138688
    Conserved Domains (2) summary
    pfam06467
    Location:375415
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11051272
    DUF3504; Domain of unknown function (DUF3504)
  8. NM_001353164.2NP_001340093.1  zinc finger MYM-type protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL137119, AL138688
    Consensus CDS
    CCDS45016.1
    Conserved Domains (2) summary
    pfam06467
    Location:462502
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11921359
    DUF3504; Domain of unknown function (DUF3504)
  9. NM_001353165.2NP_001340094.1  zinc finger MYM-type protein 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL137119
    Conserved Domains (1) summary
    pfam06467
    Location:462502
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
  10. NM_003453.6NP_003444.1  zinc finger MYM-type protein 2 isoform 1

    See identical proteins and their annotated locations for NP_003444.1

    Status: REVIEWED

    Source sequence(s)
    AL137119, AL138688
    Consensus CDS
    CCDS45016.1
    UniProtKB/Swiss-Prot
    Q9UBW7
    UniProtKB/TrEMBL
    A0A024RDS3
    Related
    ENSP00000372324.2, ENST00000382871.3
    Conserved Domains (2) summary
    pfam06467
    Location:462502
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11921359
    DUF3504; Domain of unknown function (DUF3504)
  11. NM_197968.4NP_932072.1  zinc finger MYM-type protein 2 isoform 1

    See identical proteins and their annotated locations for NP_932072.1

    Status: REVIEWED

    Source sequence(s)
    AL137119, AL138688
    Consensus CDS
    CCDS45016.1
    UniProtKB/Swiss-Prot
    Q9UBW7
    UniProtKB/TrEMBL
    A0A024RDS3, A8K126
    Related
    ENSP00000479904.1, ENST00000610343.4
    Conserved Domains (2) summary
    pfam06467
    Location:462502
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11921359
    DUF3504; Domain of unknown function (DUF3504)

RNA

  1. NR_148365.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL137119, AL138688

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    19957423..20089115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020737.1XP_016876226.1  zinc finger MYM-type protein 2 isoform X4

    Conserved Domains (2) summary
    pfam06467
    Location:375415
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11051272
    DUF3504; Domain of unknown function (DUF3504)
  2. XM_017020733.2XP_016876222.1  zinc finger MYM-type protein 2 isoform X4

    Conserved Domains (2) summary
    pfam06467
    Location:375415
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11051272
    DUF3504; Domain of unknown function (DUF3504)
  3. XM_017020731.1XP_016876220.1  zinc finger MYM-type protein 2 isoform X4

    Conserved Domains (2) summary
    pfam06467
    Location:375415
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11051272
    DUF3504; Domain of unknown function (DUF3504)
  4. XM_024449406.1XP_024305174.1  zinc finger MYM-type protein 2 isoform X1

    Conserved Domains (2) summary
    pfam06467
    Location:484524
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:12141381
    DUF3504; Domain of unknown function (DUF3504)
  5. XM_017020735.1XP_016876224.1  zinc finger MYM-type protein 2 isoform X4

    Conserved Domains (2) summary
    pfam06467
    Location:375415
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11051272
    DUF3504; Domain of unknown function (DUF3504)
  6. XM_017020734.2XP_016876223.1  zinc finger MYM-type protein 2 isoform X4

    Conserved Domains (2) summary
    pfam06467
    Location:375415
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11051272
    DUF3504; Domain of unknown function (DUF3504)
  7. XM_017020732.1XP_016876221.1  zinc finger MYM-type protein 2 isoform X4

    Conserved Domains (2) summary
    pfam06467
    Location:375415
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11051272
    DUF3504; Domain of unknown function (DUF3504)
  8. XM_005266520.3XP_005266577.1  zinc finger MYM-type protein 2 isoform X2

    See identical proteins and their annotated locations for XP_005266577.1

    UniProtKB/Swiss-Prot
    Q9UBW7
    UniProtKB/TrEMBL
    A0A024RDS3
    Conserved Domains (2) summary
    pfam06467
    Location:462502
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11921359
    DUF3504; Domain of unknown function (DUF3504)
  9. XM_024449408.1XP_024305176.1  zinc finger MYM-type protein 2 isoform X7

    Conserved Domains (1) summary
    pfam06467
    Location:484524
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
  10. XM_011535222.2XP_011533524.1  zinc finger MYM-type protein 2 isoform X3

    Conserved Domains (1) summary
    pfam06467
    Location:481524
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
  11. XM_024449407.1XP_024305175.1  zinc finger MYM-type protein 2 isoform X5

    Conserved Domains (1) summary
    pfam06467
    Location:484524
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
  12. XM_011535223.2XP_011533525.1  zinc finger MYM-type protein 2 isoform X6

    Conserved Domains (2) summary
    pfam06467
    Location:120160
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:681848
    DUF3504; Domain of unknown function (DUF3504)

RNA

  1. XR_001749660.1 RNA Sequence

  2. XR_941652.3 RNA Sequence

  3. XR_941650.3 RNA Sequence

Support Center