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CACNA1C calcium voltage-gated channel subunit alpha1 C [ Homo sapiens (human) ]

Gene ID: 775, updated on 10-Oct-2024

Summary

Official Symbol
CACNA1Cprovided by HGNC
Official Full Name
calcium voltage-gated channel subunit alpha1 Cprovided by HGNC
Primary source
HGNC:HGNC:1390
See related
Ensembl:ENSG00000151067 MIM:114205; AllianceGenome:HGNC:1390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TS; LQT8; CACH2; CACN2; CaV1.2; CCHL1A1; NEDHLSS; CACNL1A1; TS. LQT8; CACNA1C-IT2
Summary
This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]
Expression
Broad expression in endometrium (RPKM 5.2), heart (RPKM 4.5) and 19 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CACNA1C in Genome Data Viewer
Location:
12p13.33
Exon count:
57
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (1970780..2697950)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (1965666..2703402)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (2162153..2807116)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 4 Neighboring gene uncharacterized LOC124902858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2021735-2022235 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:2025891-2026467 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:2042322-2042920 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:2063223-2064422 Neighboring gene long intergenic non-protein coding RNA 940 Neighboring gene Sharpr-MPRA regulatory region 10568 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:2112705-2113344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5813 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:2120775-2121283 Neighboring gene CACNA1C intronic transcript 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4127 Neighboring gene decapping mRNA 1B Neighboring gene NANOG hESC enhancer GRCh37_chr12:2158750-2159251 Neighboring gene CACNA1C intronic transcript 2 Neighboring gene uncharacterized LOC107984131 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:2244697-2245492 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:2246289-2247084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2248447-2248948 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2248949-2249448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2292877-2293376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2296398-2296898 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:2298181-2298776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:2300389-2300956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:2300957-2301526 Neighboring gene Sharpr-MPRA regulatory region 515 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:2327895-2328089 Neighboring gene CACNA1C antisense RNA 4 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr12:2364607-2365108 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr12:2365109-2365608 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:2379570-2379768 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:2382663-2383258 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:2383259-2383852 Neighboring gene CACNA1C intronic transcript 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2446628-2447128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2456839-2457346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2460511-2461011 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2462368-2462964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2462965-2463559 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:2485885-2486488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:2486489-2487090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:2518831-2519593 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2524749-2525248 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:2534057-2534597 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:2601921-2602422 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:2602423-2602923 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2616670-2617170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2617171-2617671 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:2629110-2630309 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2642317-2642824 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:2660049-2661248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2664536-2665036 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2720576-2721076 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:2721501-2721653 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2736099-2736770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2736771-2737440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2747711-2748212 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:2760867-2761740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2786203-2786704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:2788182-2789145 Neighboring gene CACNA1C antisense RNA 2 Neighboring gene CACNA1C antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4129 Neighboring gene ribosomal protein S6 pseudogene 18 Neighboring gene calcium voltage-gated channel subunit alpha1 C pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr12:2861912-2862124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2862369-2862869 Neighboring gene long intergenic non-protein coding RNA 2371 Neighboring gene ITFG2 antisense RNA 1 Neighboring gene IQ motif and Sec7 domain 3 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2016-03-24)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated 2016-03-24)

ClinGen Genome Curation Page

EBI GWAS Catalog

Description
A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
EBI GWAS Catalog
A genome-wide association study of sleep habits and insomnia.
EBI GWAS Catalog
A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose.
EBI GWAS Catalog
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
EBI GWAS Catalog
Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.
EBI GWAS Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
EBI GWAS Catalog
Genome-wide association study identifies five new schizophrenia loci.
EBI GWAS Catalog
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
EBI GWAS Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
EBI GWAS Catalog
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
EBI GWAS Catalog
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.
EBI GWAS Catalog
Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.
EBI GWAS Catalog
Seventy-five genetic loci influencing the human red blood cell.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC120730, DKFZp761C1547

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in calcium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in calcium ion transmembrane transport via high voltage-gated calcium channel IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium ion transmembrane transport via high voltage-gated calcium channel IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transport into cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in calcium ion transport into cytosol TAS
Traceable Author Statement
more info
PubMed 
involved_in camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac conduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle cell action potential involved in contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell communication by electrical coupling involved in cardiac conduction TAS
Traceable Author Statement
more info
PubMed 
involved_in embryonic forelimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane depolarization during AV node cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane depolarization during atrial cardiac muscle cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane depolarization during cardiac muscle cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of adenylate cyclase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of muscle contraction NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of heart rate by cardiac conduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of ventricular cardiac muscle cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of L-type voltage-gated calcium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of L-type voltage-gated calcium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in Z disc ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
part_of voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated calcium channel complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
voltage-dependent L-type calcium channel subunit alpha-1C
Names
CACNA1C intronic transcript 2
CACNA1C intronic transcript 2 (non-protein coding)
DHPR, alpha-1 subunit
calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit
calcium channel, voltage-dependent, L type, alpha 1C subunit
voltage-dependent L-type Ca2+ channel alpha 1 subunit

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008801.2 RefSeqGene

    Range
    87465..732164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_334

mRNA and Protein(s)

  1. NM_000719.7NP_000710.5  voltage-dependent L-type calcium channel subunit alpha-1C isoform 18

    See identical proteins and their annotated locations for NP_000710.5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), also referred to as HLCC70, lacks three alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform 18), compared to isoform 1.
    Source sequence(s)
    AC005342, AC007618, Z34810
    Consensus CDS
    CCDS44794.1
    UniProtKB/TrEMBL
    A0A804HIZ0
    Related
    ENSP00000382563.1, ENST00000399655.6
    Conserved Domains (5) summary
    pfam00520
    Location:12361487
    Ion_trans; Ion transport protein
    pfam08763
    Location:15601631
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:16542086
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:14951558
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl01503
    Location:202291
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
  2. NM_001129827.2NP_001123299.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also referred to as HLCC90, lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1. This isoform (2) is predicted to form a non-functional calcium channel subunit because it contains an aberrant number of transmembrane domains.
    Source sequence(s)
    AC005342, AC007618, Z34821
    Consensus CDS
    CCDS44788.1
    UniProtKB/Swiss-Prot
    B2RUT3, E9PDJ0, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q13936, Q14743, Q14744, Q15877, Q4VMI7, Q4VMI8, Q4VMI9
    Related
    ENSP00000266376.6, ENST00000347598.9
    Conserved Domains (5) summary
    pfam00520
    Location:12561535
    Ion_trans; Ion transport protein
    pfam08763
    Location:16081679
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:17022134
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:15431606
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl01503
    Location:202291
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
  3. NM_001129829.2NP_001123301.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also referred to as HLCC126, lacks three alternate in-frame exons and uses two alternate in-frame splice sites in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC005342, AC007618, AY830713
    Consensus CDS
    CCDS44792.1
    UniProtKB/TrEMBL
    A0A804HIZ0
    Related
    ENSP00000341092.3, ENST00000344100.7
    Conserved Domains (5) summary
    pfam00520
    Location:141416
    Ion_trans; Ion transport protein
    pfam08763
    Location:15821672
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:16952127
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:15171580
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl01503
    Location:202291
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
  4. NM_001129830.3NP_001123302.2  voltage-dependent L-type calcium channel subunit alpha-1C isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also referred to as HLCC85, lacks two alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AC005342, AC007618, AF465484, AK309111, KF455578, Z34822
    Consensus CDS
    CCDS53736.1
    UniProtKB/Swiss-Prot
    B2RUT3, E9PDJ0, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q13936, Q14743, Q14744, Q15877, Q4VMI7, Q4VMI8, Q4VMI9
    UniProtKB/TrEMBL
    A0A0A0MR67
    Related
    ENSP00000329877.7, ENST00000327702.12
    Conserved Domains (4) summary
    pfam00520
    Location:123416
    Ion_trans; Ion transport protein
    pfam08763
    Location:15591633
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:16532123
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:14961549
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  5. NM_001129831.2NP_001123303.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also referred to as HLCC88, lacks two alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform 5), compared to isoform 1. This isoform (5) is predicted to form a non-functional calcium channel subunit because it contains an aberrant number of transmembrane domains.
    Source sequence(s)
    AC005342, AC007618, Z34819
    Consensus CDS
    CCDS44790.1
    UniProtKB/Swiss-Prot
    B2RUT3, E9PDJ0, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q13936, Q14743, Q14744, Q15877, Q4VMI7, Q4VMI8, Q4VMI9
    Related
    ENSP00000382547.1, ENST00000399638.5
    Conserved Domains (5) summary
    pfam00520
    Location:12361515
    Ion_trans; Ion transport protein
    pfam08763
    Location:15881659
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:16822114
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:15231586
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl01503
    Location:202291
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
  6. NM_001129832.2NP_001123304.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), also referred to as HLCC87, lacks two alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform 6), compared to isoform 1. This isoform (6) is predicted to form a non-functional calcium channel subunit because it contains an aberrant number of transmembrane domains.
    Source sequence(s)
    AC005342, AC007618, Z34818
    Consensus CDS
    CCDS44789.1
    UniProtKB/Swiss-Prot
    B2RUT3, E9PDJ0, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q13936, Q14743, Q14744, Q15877, Q4VMI7, Q4VMI8, Q4VMI9
    Related
    ENSP00000382515.1, ENST00000399606.5
    Conserved Domains (5) summary
    pfam00520
    Location:12561507
    Ion_trans; Ion transport protein
    pfam08763
    Location:15801651
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:16742106
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:15151578
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl01503
    Location:202291
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
  7. NM_001129833.2NP_001123305.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), also referred to has HLCC127, lacks three alternate in-frame exons and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 7), compared to isoform 1.
    Source sequence(s)
    AC005342, AC007618, AY830712
    Consensus CDS
    CCDS53735.1
    UniProtKB/TrEMBL
    A0A804HIZ0
    Related
    ENSP00000385724.3, ENST00000402845.7
    Conserved Domains (5) summary
    pfam00520
    Location:12361487
    Ion_trans; Ion transport protein
    pfam08763
    Location:15601650
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:16732105
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:14951558
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl01503
    Location:202291
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
  8. NM_001129834.2NP_001123306.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), also referred to as HLCC71, lacks three alternate in-frame exons and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 8), compared to isoform 1.
    Source sequence(s)
    AC005342, AC007618, Z34811
    Consensus CDS
    CCDS44793.1
    UniProtKB/TrEMBL
    A0A804HIZ0
    Related
    ENSP00000382530.1, ENST00000399621.5
    Conserved Domains (5) summary
    pfam00520
    Location:12361487
    Ion_trans; Ion transport protein
    pfam08763
    Location:15601650
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:16732105
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:14951558
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl01503
    Location:202291
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
  9. NM_001129835.2NP_001123307.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), also referred to has HLCC72, lacks three alternate in-frame exons and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 9), compared to isoform 1.
    Source sequence(s)
    AC005342, AC007618, Z74996
    Consensus CDS
    CCDS44799.1
    UniProtKB/TrEMBL
    A0A804HIZ0
    Related
    ENSP00000382546.1, ENST00000399637.5
    Conserved Domains (5) summary
    pfam00520
    Location:12361487
    Ion_trans; Ion transport protein
    pfam08763
    Location:15601650
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:16732105
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:14951558
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl01503
    Location:202291
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
  10. NM_001129836.2NP_001123308.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), also referred to has HLCC89, lacks three alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform 10), compared to isoform 1. This isoform (10) is predicted to form a non-functional calcium channel subunit because it contains an aberrant number of transmembrane domains.
    Source sequence(s)
    AC005342, AC007618, Z34820
    Consensus CDS
    CCDS44797.1
    UniProtKB/TrEMBL
    A0A804HIZ0
    Related
    ENSP00000382537.1, ENST00000399629.5
    Conserved Domains (5) summary
    pfam00520
    Location:12361504
    Ion_trans; Ion transport protein
    pfam08763
    Location:15771648
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:16712103
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:15121575
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl01503
    Location:202291
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
  11. NM_001129837.2NP_001123309.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), also referred to as HLCC73, lacks four alternate in-frame exons and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 11), compared to isoform 1.
    Source sequence(s)
    AC005342, AC007618, Z34812
    Consensus CDS
    CCDS44795.1
    UniProtKB/TrEMBL
    A0A804HKE9
    Related
    ENSP00000382504.1, ENST00000399595.5
    Conserved Domains (5) summary
    pfam00520
    Location:12361476
    Ion_trans; Ion transport protein
    pfam08763
    Location:15491639
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:16622094
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:14841547
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl01503
    Location:202291
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
  12. NM_001129838.2NP_001123310.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), also referred to has HLCC74, lacks four alternate in-frame exons and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 12), compared to isoform 1.
    Source sequence(s)
    AC005342, AC007618, Z34813
    Consensus CDS
    CCDS44801.1
    UniProtKB/TrEMBL
    A0A804HIZ0
    Related
    ENSP00000382500.1, ENST00000399591.5
    Conserved Domains (5) summary
    pfam00520
    Location:12361476
    Ion_trans; Ion transport protein
    pfam08763
    Location:15491639
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:16622094
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:14841547
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl01503
    Location:202291
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
  13. NM_001129839.2NP_001123311.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 13

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), also referred to has HLCC125, lacks four alternate in-frame exons and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 13), compared to isoform 1.
    Source sequence(s)
    AC005342, AC007618, AY830711
    Consensus CDS
    CCDS44796.1
    UniProtKB/TrEMBL
    A0A804HKE9
    Related
    ENSP00000382557.1, ENST00000399649.5
    Conserved Domains (5) summary
    pfam00520
    Location:12361474
    Ion_trans; Ion transport protein
    pfam08763
    Location:15471637
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:16602092
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:14821545
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl01503
    Location:202291
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
  14. NM_001129840.2NP_001123312.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 14

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), also referred to has HLCC105, lacks four alternate in-frame exons and contains an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 14), compared to isoform 1.
    Source sequence(s)
    AC005342, AC007618, AJ224873
    Consensus CDS
    CCDS44787.1
    UniProtKB/TrEMBL
    A0A804HIZ0
    Related
    ENSP00000382549.1, ENST00000399641.6
    Conserved Domains (5) summary
    pfam00520
    Location:12361487
    Ion_trans; Ion transport protein
    pfam08763
    Location:15601631
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:16542086
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:14951558
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl01503
    Location:202291
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
  15. NM_001129841.2NP_001123313.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 15

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), also referred to has HLCC69, lacks three alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform 15), compared to isoform 1.
    Source sequence(s)
    AC005342, AC007618, Z34809
    Consensus CDS
    CCDS44798.1
    UniProtKB/TrEMBL
    A0A804HIZ0
    Related
    ENSP00000382552.1, ENST00000399644.5
    Conserved Domains (5) summary
    pfam00520
    Location:12361487
    Ion_trans; Ion transport protein
    pfam08763
    Location:15601631
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:16542086
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:14951558
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl01503
    Location:202291
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
  16. NM_001129842.2NP_001123314.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 16

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), also referred to has HLCC78, lacks three alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform 16), compared to isoform 1.
    Source sequence(s)
    AC005342, AC007618, Z34816
    Consensus CDS
    CCDS44791.1
    UniProtKB/TrEMBL
    A0A804HIZ0
    Related
    ENSP00000382506.1, ENST00000399597.5
    Conserved Domains (5) summary
    pfam00520
    Location:12361487
    Ion_trans; Ion transport protein
    pfam08763
    Location:15601631
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:16542086
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:14951558
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl01503
    Location:202291
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
  17. NM_001129843.2NP_001123315.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 17

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), also referred to has HLCC77, lacks three alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform 17), compared to isoform 1.
    Source sequence(s)
    AC005342, AC007618, Z34815
    Consensus CDS
    CCDS44800.1
    UniProtKB/TrEMBL
    A0A804HIZ0
    Related
    ENSP00000382510.1, ENST00000399601.5
    Conserved Domains (5) summary
    pfam00520
    Location:12361487
    Ion_trans; Ion transport protein
    pfam08763
    Location:15601631
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:16542086
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:14951558
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl01503
    Location:202291
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
  18. NM_001129844.2NP_001123316.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 19

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19) lacks three alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform 19), compared to isoform 1.
    Source sequence(s)
    AC005342, AC005866, AC007618, BC146846
    Consensus CDS
    CCDS91637.1
    UniProtKB/TrEMBL
    A0A804HIZ0
    Related
    ENSP00000507169.1, ENST00000683482.1
    Conserved Domains (5) summary
    pfam00520
    Location:12331484
    Ion_trans; Ion transport protein
    pfam08763
    Location:15571628
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:16512083
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:14921555
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl01503
    Location:202291
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
  19. NM_001129846.2NP_001123318.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 20

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), also referred to as HLCC76, lacks four alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform 20), compared to isoform 1.
    Source sequence(s)
    AC005342, AC007618, Z34814
    Consensus CDS
    CCDS91636.1
    UniProtKB/TrEMBL
    A0A804HIZ0
    Related
    ENSP00000507309.1, ENST00000682686.1
    Conserved Domains (5) summary
    pfam00520
    Location:12361476
    Ion_trans; Ion transport protein
    pfam08763
    Location:15491620
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:16432075
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:14841547
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl01503
    Location:202291
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
  20. NM_001167623.2NP_001161095.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 21

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21) lacks four alternate in-frame exons and contains another alternate in-frame exon compared to variant 1, resulting in a shorter protein (isoform 21), compared to isoform 1.
    Source sequence(s)
    AC005342, AC007618, AF465484, L29536, Z34816
    Consensus CDS
    CCDS53734.1
    UniProtKB/TrEMBL
    A0A804HIZ0
    Related
    ENSP00000382512.1, ENST00000399603.6
    Conserved Domains (5) summary
    pfam00520
    Location:12361487
    Ion_trans; Ion transport protein
    pfam08763
    Location:15601631
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:16542086
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:14951558
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl01503
    Location:202291
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
  21. NM_001167624.3NP_001161096.2  voltage-dependent L-type calcium channel subunit alpha-1C isoform 22

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22) lacks two alternate in-frame exons and contains another alternate in-frame exon compared to variant 1, resulting in a shorter protein (isoform 22), compared to isoform 1.
    Source sequence(s)
    AC005342, AC007618, AF465484, AK309111, KF455578, L29534, Z34816
    Consensus CDS
    CCDS53733.1
    UniProtKB/Swiss-Prot
    B2RUT3, E9PDJ0, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q13936, Q14743, Q14744, Q15877, Q4VMI7, Q4VMI8, Q4VMI9
    UniProtKB/TrEMBL
    A0A0A0MSA1
    Related
    ENSP00000382526.1, ENST00000399617.6
    Conserved Domains (4) summary
    pfam00520
    Location:12181487
    Ion_trans; Ion transport protein
    pfam08763
    Location:15591633
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:16532123
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:14961549
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  22. NM_001167625.2NP_001161097.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform 23

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23) lacks five alternate in-frame exons and contains another two alternate in-frame exons compared to variant 1, resulting in a shorter protein (isoform 23), compared to isoform 1.
    Source sequence(s)
    AC005342, AC007618, AF465484, L29529, Z34814
    Consensus CDS
    CCDS91634.1
    UniProtKB/TrEMBL
    E9PDI6, F5GY28
    Related
    ENSP00000382542.2, ENST00000399634.6
    Conserved Domains (5) summary
    pfam00520
    Location:12361476
    Ion_trans; Ion transport protein
    pfam08763
    Location:15491620
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:18802146
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:14841547
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl01503
    Location:202291
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
  23. NM_199460.4NP_955630.3  voltage-dependent L-type calcium channel subunit alpha-1C isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also referred to as HFCC, encodes the longest isoform (1). This isoform (1) is predicted to form a non-functional calcium channel subunit because it contains an aberrant number of transmembrane domains.
    Source sequence(s)
    AB209016, AC005342, AC007618, AF465484, AK309111, AY562395, KF455578, L29534, L29536, Z34816, Z34822
    UniProtKB/Swiss-Prot
    B2RUT3, E9PDJ0, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q13936, Q14743, Q14744, Q15877, Q4VMI7, Q4VMI8, Q4VMI9
    Related
    ENSP00000507184.1, ENST00000682544.1
    Conserved Domains (4) summary
    pfam00520
    Location:123416
    Ion_trans; Ion transport protein
    pfam08763
    Location:16071681
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:17012171
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:15441597
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    1970780..2697950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019926.3XP_016875415.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1

    UniProtKB/TrEMBL
    A0A804HIR0
  2. XM_017019934.3XP_016875423.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X16

    UniProtKB/TrEMBL
    A0A804HJR1
  3. XM_017019946.3XP_016875435.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X20

    UniProtKB/TrEMBL
    A0A804HJR1
  4. XM_017019943.3XP_016875432.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X19

    UniProtKB/TrEMBL
    A0A804HJR1
  5. XM_017019932.3XP_016875421.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X11

    UniProtKB/TrEMBL
    F5GY28
  6. XM_017019949.3XP_016875438.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X25

    UniProtKB/TrEMBL
    A0A804HJR1
  7. XM_017019947.3XP_016875436.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X23

    UniProtKB/TrEMBL
    A0A804HJR1
    Related
    ENSP00000507612.1, ENST00000683840.1
  8. XM_017019950.3XP_016875439.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X26

    UniProtKB/TrEMBL
    A0A804HJR1
  9. XM_017019927.3XP_016875416.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X2

    UniProtKB/TrEMBL
    A0A804HIR0
  10. XM_017019928.3XP_016875417.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X4

    UniProtKB/TrEMBL
    A0A804HIR0
  11. XM_047429513.1XP_047285469.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X3

  12. XM_017019929.3XP_016875418.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X5

    UniProtKB/TrEMBL
    A0A804HIR0
  13. XM_047429514.1XP_047285470.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X7

  14. XM_047429515.1XP_047285471.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X8

  15. XM_047429516.1XP_047285472.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X10

  16. XM_047429517.1XP_047285473.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X12

  17. XM_017019930.3XP_016875419.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X6

    UniProtKB/TrEMBL
    A0A804HJR1
  18. XM_017019931.3XP_016875420.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X9

    UniProtKB/TrEMBL
    A0A804HJR1
  19. XM_047429518.1XP_047285474.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X13

  20. XM_017019935.3XP_016875424.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X15

    UniProtKB/TrEMBL
    A0A804HJR1
  21. XM_047429519.1XP_047285475.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X17

  22. XM_017019955.3XP_016875444.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X32

    UniProtKB/TrEMBL
    A0A804HJR1
  23. XM_017019933.3XP_016875422.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X14

    UniProtKB/TrEMBL
    A0A804HIR0
  24. XM_017019944.3XP_016875433.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X21

    UniProtKB/TrEMBL
    A0A804HJR1
  25. XM_017019939.3XP_016875428.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X18

    UniProtKB/TrEMBL
    A0A804HJR1
  26. XM_017019948.3XP_016875437.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X24

    UniProtKB/TrEMBL
    A0A804HJR1
  27. XM_017019945.3XP_016875434.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X22

    UniProtKB/TrEMBL
    A0A804HJR1
  28. XM_011521020.3XP_011519322.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X28

    UniProtKB/TrEMBL
    A0A804HJR1, A0A804HKC4
    Related
    ENSP00000507867.1, ENST00000683824.1
    Conserved Domains (5) summary
    pfam00520
    Location:12911542
    Ion_trans; Ion transport protein
    pfam08763
    Location:16151686
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:17092141
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:15501613
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl01503
    Location:232321
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
  29. XM_017019954.2XP_016875443.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X31

    UniProtKB/TrEMBL
    A0A804HIJ8, A0A804HJR1
    Related
    ENSP00000507105.1, ENST00000682462.1
  30. XM_006719017.3XP_006719080.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X30

    UniProtKB/TrEMBL
    A0A804HJB6, A0A804HJR1
    Related
    ENSP00000507434.1, ENST00000683781.1
    Conserved Domains (5) summary
    pfam00520
    Location:12661517
    Ion_trans; Ion transport protein
    pfam08763
    Location:15901661
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:16842116
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:15251588
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl01503
    Location:232321
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
  31. XM_017019953.2XP_016875442.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X29

    UniProtKB/TrEMBL
    A0A804HI37, A0A804HJR1
    Related
    ENSP00000506882.1, ENST00000683956.1
  32. XM_011521023.4XP_011519325.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X33

    UniProtKB/TrEMBL
    A0A804HKE9, F5H522
    Related
    ENSP00000336982.5, ENST00000335762.10
    Conserved Domains (5) summary
    pfam00520
    Location:12611512
    Ion_trans; Ion transport protein
    pfam08763
    Location:15851656
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:16792111
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:15201583
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl01503
    Location:202291
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
  33. XM_047429520.1XP_047285476.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X27

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654718.1 Reference GRCh38.p14 PATCHES

    Range
    311696..1046066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332286.1XP_054188261.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1

  2. XM_054332301.1XP_054188276.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X16

  3. XM_054332305.1XP_054188280.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X20

  4. XM_054332304.1XP_054188279.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X19

  5. XM_054332296.1XP_054188271.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X11

  6. XM_054332310.1XP_054188285.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X25

  7. XM_054332308.1XP_054188283.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X23

  8. XM_054332311.1XP_054188286.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X26

  9. XM_054332287.1XP_054188262.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X2

  10. XM_054332289.1XP_054188264.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X4

  11. XM_054332288.1XP_054188263.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X3

  12. XM_054332290.1XP_054188265.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X5

  13. XM_054332292.1XP_054188267.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X7

  14. XM_054332293.1XP_054188268.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X8

  15. XM_054332295.1XP_054188270.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X10

  16. XM_054332297.1XP_054188272.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X12

  17. XM_054332291.1XP_054188266.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X6

  18. XM_054332294.1XP_054188269.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X9

  19. XM_054332298.1XP_054188273.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X13

  20. XM_054332300.1XP_054188275.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X15

  21. XM_054332302.1XP_054188277.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X17

  22. XM_054332317.1XP_054188292.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X32

  23. XM_054332299.1XP_054188274.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X14

  24. XM_054332306.1XP_054188281.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X21

  25. XM_054332303.1XP_054188278.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X18

  26. XM_054332309.1XP_054188284.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X24

  27. XM_054332307.1XP_054188282.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X22

  28. XM_054332313.1XP_054188288.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X28

    UniProtKB/TrEMBL
    A0A804HKC4
  29. XM_054332316.1XP_054188291.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X31

    UniProtKB/TrEMBL
    A0A804HIJ8
  30. XM_054332315.1XP_054188290.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X30

    UniProtKB/TrEMBL
    A0A804HJB6
  31. XM_054332314.1XP_054188289.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X29

    UniProtKB/TrEMBL
    A0A804HI37
  32. XM_054332318.1XP_054188293.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X33

    UniProtKB/TrEMBL
    F5H522
  33. XM_054332312.1XP_054188287.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X27

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    1965666..2703402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373150.1XP_054229125.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1

  2. XM_054373165.1XP_054229140.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X16

  3. XM_054373169.1XP_054229144.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X20

  4. XM_054373168.1XP_054229143.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X19

  5. XM_054373160.1XP_054229135.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X11

  6. XM_054373174.1XP_054229149.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X25

  7. XM_054373172.1XP_054229147.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X23

  8. XM_054373175.1XP_054229150.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X26

  9. XM_054373151.1XP_054229126.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X2

  10. XM_054373153.1XP_054229128.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X4

  11. XM_054373152.1XP_054229127.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X3

  12. XM_054373154.1XP_054229129.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X5

  13. XM_054373156.1XP_054229131.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X7

  14. XM_054373157.1XP_054229132.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X8

  15. XM_054373159.1XP_054229134.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X10

  16. XM_054373161.1XP_054229136.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X12

  17. XM_054373155.1XP_054229130.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X6

  18. XM_054373158.1XP_054229133.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X9

  19. XM_054373162.1XP_054229137.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X13

  20. XM_054373164.1XP_054229139.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X15

  21. XM_054373166.1XP_054229141.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X17

  22. XM_054373181.1XP_054229156.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X32

  23. XM_054373163.1XP_054229138.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X14

  24. XM_054373170.1XP_054229145.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X21

  25. XM_054373167.1XP_054229142.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X18

  26. XM_054373173.1XP_054229148.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X24

  27. XM_054373171.1XP_054229146.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X22

  28. XM_054373177.1XP_054229152.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X28

    UniProtKB/TrEMBL
    A0A804HKC4
  29. XM_054373180.1XP_054229155.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X31

    UniProtKB/TrEMBL
    A0A804HIJ8
  30. XM_054373179.1XP_054229154.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X30

    UniProtKB/TrEMBL
    A0A804HJB6
  31. XM_054373178.1XP_054229153.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X29

    UniProtKB/TrEMBL
    A0A804HI37
  32. XM_054373182.1XP_054229157.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X33

    UniProtKB/TrEMBL
    F5H522
  33. XM_054373176.1XP_054229151.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X27