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ZNF195 zinc finger protein 195 [ Homo sapiens (human) ]

Gene ID: 7748, updated on 11-Jun-2021

Summary

Official Symbol
ZNF195provided by HGNC
Official Full Name
zinc finger protein 195provided by HGNC
Primary source
HGNC:HGNC:12986
See related
Ensembl:ENSG00000005801 MIM:602187
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRF1; ZNFP104
Summary
This gene encodes a protein belonging to the Krueppel C2H2-type zinc-finger protein family. These family members are transcription factors that are implicated in a variety of cellular processes. This gene is located near the centromeric border of chromosome 11p15.5, next to an imprinted domain that is associated with maternal-specific loss of heterozygosity in Wilms' tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in brain (RPKM 4.9), thyroid (RPKM 4.7) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF195 in Genome Data Viewer
Location:
11p15.4
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (3357927..3379146, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (3379157..3400376, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A5 pseudogene 1 Neighboring gene vomeronasal 1 receptor 56 pseudogene Neighboring gene Sharpr-MPRA regulatory region 5988 Neighboring gene tumor suppressing subtransferable candidate 2 (pseudogene) Neighboring gene olfactory receptor family 7 subfamily E member 12 pseudogene Neighboring gene family with sequence similarity 86, member A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp666D035

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 195
Names
hypoxia-regulated factor-1
krueppel family zinc finger protein (znfp104)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032109.1 RefSeqGene

    Range
    5077..26296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130519.3NP_001123991.1  zinc finger protein 195 isoform 2

    See identical proteins and their annotated locations for NP_001123991.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC123788, AL833722, BC121029
    Consensus CDS
    CCDS44521.1
    UniProtKB/Swiss-Prot
    O14628
    Related
    ENSP00000005082.9, ENST00000005082.13
    Conserved Domains (3) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    COG5048
    Location:202606
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:501521
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001130520.3NP_001123992.1  zinc finger protein 195 isoform 1

    See identical proteins and their annotated locations for NP_001123992.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC123788, AK290099, AL833722
    Consensus CDS
    CCDS44522.1
    UniProtKB/Swiss-Prot
    O14628
    Related
    ENSP00000382511.4, ENST00000399602.9
    Conserved Domains (5) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    COG5048
    Location:225629
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:524544
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:592617
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001242841.2NP_001229770.1  zinc finger protein 195 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR, uses an alternate start codon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC123788, AK293679, AL833722
    Consensus CDS
    CCDS55737.1
    UniProtKB/Swiss-Prot
    O14628
    Related
    ENSP00000435828.1, ENST00000526601.5
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:206610
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:505525
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:573598
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001242842.2NP_001229771.1  zinc finger protein 195 isoform 5

    See identical proteins and their annotated locations for NP_001229771.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR, uses an alternate start codon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (5) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC123788, AK308068, AL833722
    UniProtKB/Swiss-Prot
    O14628
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:180584
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:479499
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:547572
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001242843.2NP_001229772.1  zinc finger protein 195 isoform 6

    See identical proteins and their annotated locations for NP_001229772.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in its 5' UTR, uses an alternate start codon, and lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. The encoded isoform (6) has a distinct N-terminus and is shorter than isoform 1. Both variants 6 and 12 encode isoform 6.
    Source sequence(s)
    AC123788, AL833722, CX867141
    Consensus CDS
    CCDS55736.1
    UniProtKB/Swiss-Prot
    O14628
    Related
    ENSP00000387998.2, ENST00000429541.6
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:157561
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:456476
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:524549
    zf-H2C2_2; Zinc-finger double domain
  6. NM_001256823.2NP_001243752.1  zinc finger protein 195 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in its 5' UTR, uses an alternate start codon, and lacks two alternate exons but includes an additional exon that causes a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (7) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AC123788, AL833722, BM462194
    Consensus CDS
    CCDS58111.1
    UniProtKB/Swiss-Prot
    O14628
    Related
    ENSP00000414353.2, ENST00000438262.6
    Conserved Domains (2) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    pfam01352
    Location:847
    KRAB; KRAB box
  7. NM_001256824.2NP_001243753.1  zinc finger protein 195 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in its 5' UTR, uses an alternate start codon, uses an alternate in-frame splice site and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (8) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC123788, AL833722, DA713258
    UniProtKB/Swiss-Prot
    O14628
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:188592
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:487507
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:555580
    zf-H2C2_2; Zinc-finger double domain
  8. NM_001256825.2NP_001243754.1  zinc finger protein 195 isoform 6

    See identical proteins and their annotated locations for NP_001243754.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in its 5' UTR, uses an alternate start codon, and lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. The encoded isoform (6) has a distinct N-terminus and is shorter than isoform 1. Both variants 6 and 12 encode isoform 6.
    Source sequence(s)
    AC123788, AL833722, DA618142
    Consensus CDS
    CCDS55736.1
    UniProtKB/Swiss-Prot
    O14628
    Related
    ENSP00000344483.7, ENST00000343338.11
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:157561
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:456476
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:524549
    zf-H2C2_2; Zinc-finger double domain
  9. NM_007152.5NP_009083.2  zinc finger protein 195 isoform 3

    See identical proteins and their annotated locations for NP_009083.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AC123788, AL833722
    Consensus CDS
    CCDS41604.1
    UniProtKB/Swiss-Prot
    O14628
    Related
    ENSP00000346613.6, ENST00000354599.10
    Conserved Domains (5) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    COG5048
    Location:320497
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:520545
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_040083.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) includes two additional exons in the 5' region, and lacks two exons in the 3' region, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest in-frame ORF. Translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC123788, AK131296, AL833722
  2. NR_046381.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) includes an additional exon in both the 5' and 3' regions, but lacks a different exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 4, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC123788, AL833722, DB294374
  3. NR_046382.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) includes an additional exon in the 5' region, and lacks two exons in the 3' region, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest in-frame ORF. Translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC123788, AL833722, DA170927, DA984929

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    3357927..3379146 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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