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Esrp2 epithelial splicing regulatory protein 2 [ Mus musculus (house mouse) ]

Gene ID: 77411, updated on 12-May-2024

Summary

Official Symbol
Esrp2provided by MGI
Official Full Name
epithelial splicing regulatory protein 2provided by MGI
Primary source
MGI:MGI:1924661
See related
Ensembl:ENSMUSG00000084128 AllianceGenome:MGI:1924661
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rbm35b; 9530027K23Rik
Summary
Predicted to enable mRNA binding activity. Acts upstream of or within alternative mRNA splicing, via spliceosome; morphogenesis of a branching epithelium; and positive regulation of epithelial cell proliferation. Predicted to be located in nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nose; respiratory system; and skin. Orthologous to human ESRP2 (epithelial splicing regulatory protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach adult (RPKM 34.4), liver adult (RPKM 30.9) and 16 other tissues See more
Orthologs
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Genomic context

See Esrp2 in Genome Data Viewer
Location:
8 D3; 8 53.1 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106856658..106863825, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (106130319..106137193, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22972 Neighboring gene dipeptidase 2 Neighboring gene DEAD box helicase 28 Neighboring gene dihydrouridine synthase 2 Neighboring gene STARR-positive B cell enhancer ABC_E1375 Neighboring gene STARR-positive B cell enhancer ABC_E3801 Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:108636517-108636718 Neighboring gene RIKEN cDNA 1810019D21 gene Neighboring gene STARR-positive B cell enhancer ABC_E9739 Neighboring gene STARR-positive B cell enhancer mm9_chr8:108674075-108674376 Neighboring gene phospholipase A2, group XV Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
epithelial splicing regulatory protein 2
Names
RNA binding motif protein 35b
RNA-binding motif protein 35B
RNA-binding protein 35B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176838.2NP_789808.1  epithelial splicing regulatory protein 2

    See identical proteins and their annotated locations for NP_789808.1

    Status: PROVISIONAL

    Source sequence(s)
    BC031444
    Consensus CDS
    CCDS22629.1
    UniProtKB/Swiss-Prot
    Q8CEK2, Q8K0G8
    UniProtKB/TrEMBL
    D3Z139
    Related
    ENSMUSP00000111639.3, ENSMUST00000115979.9
    Conserved Domains (4) summary
    cd12507
    Location:248322
    RRM1_ESRPs_Fusilli; RNA recognition motif 1 in epithelial splicing regulatory protein ESRP1, ESRP2, Drosophila RNA-binding protein Fusilli and similar proteins
    cd12742
    Location:464544
    RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    cl10012
    Location:82214
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl17169
    Location:332438
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106856658..106863825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243854.2XP_030099714.1  epithelial splicing regulatory protein 2 isoform X2

    Conserved Domains (4) summary
    PHA03247
    Location:423532
    PHA03247; large tegument protein UL36; Provisional
    cd12737
    Location:116195
    RRM1_ESRP2; RNA recognition motif 1 in epithelial splicing regulatory protein 2 (ESRP2) and similar proteins
    cd12742
    Location:332412
    RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    cl17169
    Location:200306
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. XM_006531492.4XP_006531555.1  epithelial splicing regulatory protein 2 isoform X1

    UniProtKB/TrEMBL
    D3Z139
    Conserved Domains (5) summary
    PHA03247
    Location:554663
    PHA03247; large tegument protein UL36; Provisional
    cd12507
    Location:247321
    RRM1_ESRPs_Fusilli; RNA recognition motif 1 in epithelial splicing regulatory protein ESRP1, ESRP2, Drosophila RNA-binding protein Fusilli and similar proteins
    cd12742
    Location:463543
    RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    cl10012
    Location:82214
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl17169
    Location:331437
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. XM_011248547.3XP_011246849.1  epithelial splicing regulatory protein 2 isoform X3

    Conserved Domains (3) summary
    cd12507
    Location:248322
    RRM1_ESRPs_Fusilli; RNA recognition motif 1 in epithelial splicing regulatory protein ESRP1, ESRP2, Drosophila RNA-binding protein Fusilli and similar proteins
    cl10012
    Location:82214
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl17169
    Location:332433
    RRM_SF; RNA recognition motif (RRM) superfamily