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ZNF185 zinc finger protein 185 with LIM domain [ Homo sapiens (human) ]

Gene ID: 7739, updated on 16-Oct-2021

Summary

Official Symbol
ZNF185provided by HGNC
Official Full Name
zinc finger protein 185 with LIM domainprovided by HGNC
Primary source
HGNC:HGNC:12976
See related
Ensembl:ENSG00000147394 MIM:300381
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCELL
Summary
Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a LIM-domain zinc finger protein. The LIM domain is composed of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker. The LIM domain mediates protein:protein interactions. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010]
Expression
Biased expression in esophagus (RPKM 112.2), skin (RPKM 20.8) and 4 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See ZNF185 in Genome Data Viewer
Location:
Xq28
Exon count:
28
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (152898067..152973481)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (152082986..152142025)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene centrin 2 Neighboring gene NAD(P) dependent steroid dehydrogenase-like Neighboring gene uncharacterized LOC105373372 Neighboring gene PNMA family member 5 Neighboring gene paraneoplastic antigen Ma6F-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 185
Names
P1-A
sciellin like
zinc finger protein 185 (LIM domain)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021255.2 RefSeqGene

    Range
    5001..64040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178106.1NP_001171577.1  zinc finger protein 185 isoform 1

    See identical proteins and their annotated locations for NP_001171577.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK056517, BQ923456, DC305824, DQ508025, DQ508026
    Consensus CDS
    CCDS55529.1
    UniProtKB/Swiss-Prot
    O15231
    UniProtKB/TrEMBL
    B3KPM4
    Related
    ENSP00000440847.1, ENST00000535861.5
    Conserved Domains (1) summary
    smart00132
    Location:660716
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
  2. NM_001178107.1NP_001171578.1  zinc finger protein 185 isoform 2

    See identical proteins and their annotated locations for NP_001171578.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AK056517, BQ923456, DC305824, DQ508024, DQ508026
    Consensus CDS
    CCDS55530.1
    UniProtKB/Swiss-Prot
    O15231
    UniProtKB/TrEMBL
    B3KPM4
    Related
    ENSP00000444367.1, ENST00000539731.5
    Conserved Domains (1) summary
    smart00132
    Location:631687
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
  3. NM_001178108.2NP_001171579.1  zinc finger protein 185 isoform 3

    See identical proteins and their annotated locations for NP_001171579.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has additional 3 nts in one splice site and lacks two consecutive in-frame exons in another splice junction in the CDS, as compared to variant 1. The resulting isoform (3) has additional one aa in one region and lacks an internal segment in another region, as compared to isoform 1.
    Source sequence(s)
    U82671
    Consensus CDS
    CCDS55528.1
    UniProtKB/Swiss-Prot
    O15231
    UniProtKB/TrEMBL
    B3KPM4
    Related
    ENSP00000395228.2, ENST00000449285.6
    Conserved Domains (2) summary
    smart00132
    Location:629685
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    PRK07764
    Location:178517
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
  4. NM_001178109.1NP_001171580.1  zinc finger protein 185 isoform 5

    See identical proteins and their annotated locations for NP_001171580.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two in-frame exons in the CDS, as compared to variant 1. The resulting isoform (5) lacks two internal segments, as compared to isoform 1.
    Source sequence(s)
    AK056517, BQ923456, DC305824, DQ508024
    UniProtKB/Swiss-Prot
    O15231
    UniProtKB/TrEMBL
    B3KPM4
    Conserved Domains (1) summary
    smart00132
    Location:599655
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
  5. NM_001178110.1NP_001171581.1  zinc finger protein 185 isoform 6

    See identical proteins and their annotated locations for NP_001171581.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two consecutive in-frame exons in one region and an in-frame exon in another region in the CDS, as compared to variant 1. The resulting isoform (6) lacks two internal segments, as compared to isoform 1.
    Source sequence(s)
    AK056517, BQ923456, DC305824, DQ508023
    Consensus CDS
    CCDS55531.1
    UniProtKB/Swiss-Prot
    O15231
    UniProtKB/TrEMBL
    B3KPM4
    Related
    ENSP00000312782.7, ENST00000318504.11
    Conserved Domains (1) summary
    smart00132
    Location:569625
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
  6. NM_001178113.2NP_001171584.1  zinc finger protein 185 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and has multiple differences in the 5' coding region including a downstream in-frame AUG start codon, as compared to variant 1. The resulting isoform (7) has a much shorter N-terminus and an additional aa in one region, and lacks three segments in other regions, as compared to isoform 1.
    Source sequence(s)
    AK056517, AK301530, BQ923456, DQ508023, U82671
    Consensus CDS
    CCDS55532.1
    UniProtKB/Swiss-Prot
    O15231
    UniProtKB/TrEMBL
    B3KPM4
    Related
    ENSP00000313919.8, ENST00000318529.12
    Conserved Domains (1) summary
    smart00132
    Location:407463
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
  7. NM_001178115.2NP_001171586.1  zinc finger protein 185 isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks multiple 5' eons, but has an alternate 5' exon, as compared to variant 1. The resulting isoform (9) is much shorter and has a different N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK056517, AK095258, BQ923456, DA882423
    Consensus CDS
    CCDS69832.1
    UniProtKB/Swiss-Prot
    O15231
    UniProtKB/TrEMBL
    B3KPM4
    Related
    ENSP00000392984.2, ENST00000454925.1
    Conserved Domains (1) summary
    smart00132
    Location:266322
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
  8. NM_001388432.2NP_001375361.1  zinc finger protein 185 isoform 3

    Status: REVIEWED

    Source sequence(s)
    U82671
    Conserved Domains (2) summary
    smart00132
    Location:629685
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    PRK07764
    Location:178517
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
  9. NM_001395254.1NP_001382183.1  zinc finger protein 185 isoform 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) represents the longest transcript and encodes the longest isoform (10).
    Source sequence(s)
    U82671
    Conserved Domains (1) summary
    smart00132
    Location:661717
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
  10. NM_007150.3NP_009081.2  zinc finger protein 185 isoform 4

    See identical proteins and their annotated locations for NP_009081.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (4) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AK056517, AY997296, BQ923456, DC347990
    Consensus CDS
    CCDS48184.1
    UniProtKB/Swiss-Prot
    O15231
    UniProtKB/TrEMBL
    B3KPM4
    Related
    ENSP00000359291.4, ENST00000370268.8
    Conserved Domains (1) summary
    smart00132
    Location:628684
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    152898067..152973481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029821.1XP_016885310.1  zinc finger protein 185 isoform X1

  2. XM_005274730.2XP_005274787.1  zinc finger protein 185 isoform X8

    Conserved Domains (1) summary
    smart00132
    Location:661717
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
  3. XM_011531195.1XP_011529497.1  zinc finger protein 185 isoform X24

    Conserved Domains (1) summary
    smart00132
    Location:595651
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
  4. XM_017029828.1XP_016885317.1  zinc finger protein 185 isoform X7

  5. XM_017029832.1XP_016885321.1  zinc finger protein 185 isoform X13

  6. XM_011531194.1XP_011529496.1  zinc finger protein 185 isoform X23

    Conserved Domains (1) summary
    smart00132
    Location:596652
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
  7. XM_017029825.1XP_016885314.1  zinc finger protein 185 isoform X4

  8. XM_017029830.1XP_016885319.1  zinc finger protein 185 isoform X11

  9. XM_017029826.1XP_016885315.1  zinc finger protein 185 isoform X5

  10. XM_017029831.1XP_016885320.1  zinc finger protein 185 isoform X12

  11. XM_005274740.2XP_005274797.1  zinc finger protein 185 isoform X20

    Conserved Domains (1) summary
    smart00132
    Location:599655
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
  12. XM_017029829.1XP_016885318.1  zinc finger protein 185 isoform X10

  13. XM_017029834.1XP_016885323.1  zinc finger protein 185 isoform X18

  14. XM_005274744.2XP_005274801.1  zinc finger protein 185 isoform X25

    Conserved Domains (1) summary
    smart00132
    Location:570626
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
  15. XM_017029823.1XP_016885312.1  zinc finger protein 185 isoform X2

  16. XM_005274731.2XP_005274788.1  zinc finger protein 185 isoform X9

    See identical proteins and their annotated locations for XP_005274788.1

    UniProtKB/Swiss-Prot
    O15231
    Conserved Domains (1) summary
    smart00132
    Location:660716
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
  17. XM_005274738.2XP_005274795.1  zinc finger protein 185 isoform X16

    See identical proteins and their annotated locations for XP_005274795.1

    UniProtKB/Swiss-Prot
    O15231
    Conserved Domains (1) summary
    smart00132
    Location:628684
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
  18. XM_005274735.2XP_005274792.1  zinc finger protein 185 isoform X14

    See identical proteins and their annotated locations for XP_005274792.1

    UniProtKB/Swiss-Prot
    O15231
    Conserved Domains (1) summary
    smart00132
    Location:631687
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
  19. XM_005274741.2XP_005274798.1  zinc finger protein 185 isoform X21

    See identical proteins and their annotated locations for XP_005274798.1

    UniProtKB/Swiss-Prot
    O15231
    Conserved Domains (1) summary
    smart00132
    Location:599655
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
  20. XM_017029827.1XP_016885316.1  zinc finger protein 185 isoform X6

  21. XM_005274742.2XP_005274799.1  zinc finger protein 185 isoform X22

    Conserved Domains (1) summary
    smart00132
    Location:598654
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
  22. XM_017029835.1XP_016885324.1  zinc finger protein 185 isoform X19

  23. XM_005274745.2XP_005274802.1  zinc finger protein 185 isoform X26

    See identical proteins and their annotated locations for XP_005274802.1

    UniProtKB/Swiss-Prot
    O15231
    Conserved Domains (1) summary
    smart00132
    Location:569625
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
  24. XM_017029824.1XP_016885313.1  zinc finger protein 185 isoform X3

  25. XM_017029833.1XP_016885322.1  zinc finger protein 185 isoform X17

  26. XM_005274746.3XP_005274803.1  zinc finger protein 185 isoform X27

    Conserved Domains (1) summary
    smart00132
    Location:542598
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
  27. XM_017029822.2XP_016885311.1  zinc finger protein 185 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001178114.1: Suppressed sequence

    Description
    NM_001178114.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which uses a poorly supported non-consensus splice site.
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