Format

Send to:

Choose Destination

ZNF184 zinc finger protein 184 [ Homo sapiens (human) ]

Gene ID: 7738, updated on 26-Jul-2021

Summary

Official Symbol
ZNF184provided by HGNC
Official Full Name
zinc finger protein 184provided by HGNC
Primary source
HGNC:HGNC:12975
See related
Ensembl:ENSG00000096654 MIM:602277
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
kr-ZNF3
Summary
The protein encoded by this gene is predicted to be a Kruppel C2H2-type zinc-finger protein family member. Sequence analysis predicts that the protein contains two Kruppel associated box (KRAB) boxes in the N-terminus and highly conserved zinc finger motifs at the C-terminus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016]
Expression
Ubiquitous expression in testis (RPKM 5.2), brain (RPKM 3.7) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ZNF184 in Genome Data Viewer
Location:
6p22.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (27404006..27473105, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (27371785..27440884, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene tRNA-Lys (anticodon TTT) 6-1 Neighboring gene zinc finger protein 204, pseudogene Neighboring gene zinc finger protein 391 Neighboring gene multiple coagulation factor deficiency 2 pseudogene 1 Neighboring gene uncharacterized LOC105375001 Neighboring gene tRNA-Ser (anticodon AGA) 2-2 Neighboring gene tRNA-Asp (anticodon GTC) 2-6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Common variants on chromosome 6p22.1 are associated with schizophrenia.
GeneReviews: Not available
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 184
Names
zinc finger protein 184 (Kruppel-like)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052614.1 RefSeqGene

    Range
    5001..27377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001318891.2NP_001305820.1  zinc finger protein 184 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2, and 3, encode the same isoform (1).
    Source sequence(s)
    AK123011, AK312804, BC022992, BM675205, BX496218, DB090589
    Consensus CDS
    CCDS4624.1
    UniProtKB/Swiss-Prot
    Q99676
    UniProtKB/TrEMBL
    A0A024RCM2
    Related
    ENSP00000508298.1, ENST00000683788.1
    Conserved Domains (6) summary
    smart00349
    Location:2888
    KRAB; krueppel associated box
    COG5048
    Location:360736
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:308328
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:418440
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2867
    KRAB; KRAB box
    pfam13465
    Location:292317
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001318892.2NP_001305821.1  zinc finger protein 184 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3, encode the same isoform (1).
    Source sequence(s)
    AL021918, BC022992, BM675205, BX496218, DB076907, DB244087
    Consensus CDS
    CCDS4624.1
    UniProtKB/Swiss-Prot
    Q99676
    UniProtKB/TrEMBL
    A0A024RCM2
    Related
    ENSP00000366636.1, ENST00000377419.1
    Conserved Domains (6) summary
    smart00349
    Location:2888
    KRAB; krueppel associated box
    COG5048
    Location:360736
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:308328
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:418440
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2867
    KRAB; KRAB box
    pfam13465
    Location:292317
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001318893.2NP_001305822.1  zinc finger protein 184 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' coding region and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Variants 4 and 5 encode the same isoform (2).
    Source sequence(s)
    AL021918, BC022992, BM675205, CX870289, DB090589
    UniProtKB/Swiss-Prot
    Q99676
    Conserved Domains (2) summary
    COG5048
    Location:284660
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:232252
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001347832.2NP_001334761.1  zinc finger protein 184 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, uses an alternate splice site in the 5' coding region and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Variants 4 and 5 encode the same isoform (2).
    Source sequence(s)
    AL021918, BC022992, BM675205, CX870289, DB090589
    UniProtKB/Swiss-Prot
    Q99676
    Conserved Domains (2) summary
    COG5048
    Location:284660
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:232252
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_007149.3NP_009080.2  zinc finger protein 184 isoform 1

    See identical proteins and their annotated locations for NP_009080.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, and 3, encode the same isoform (1).
    Source sequence(s)
    AK123011, BC022992, BM675205, DB090589
    Consensus CDS
    CCDS4624.1
    UniProtKB/Swiss-Prot
    Q99676
    UniProtKB/TrEMBL
    A0A024RCM2
    Related
    ENSP00000211936.6, ENST00000211936.10
    Conserved Domains (6) summary
    smart00349
    Location:2888
    KRAB; krueppel associated box
    COG5048
    Location:360736
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:308328
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:418440
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2867
    KRAB; KRAB box
    pfam13465
    Location:292317
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_144687.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA355479, AI610079, AL031118, DA315543, DB090589
  2. NR_144688.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA355479, AL031118, DA315543, DB090589

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    27404006..27473105 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center