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Akr1c21 aldo-keto reductase family 1, member C21 [ Mus musculus (house mouse) ]

Gene ID: 77337, updated on 8-Feb-2024

Summary

Official Symbol
Akr1c21provided by MGI
Official Full Name
aldo-keto reductase family 1, member C21provided by MGI
Primary source
MGI:MGI:1924587
See related
Ensembl:ENSMUSG00000021207 AllianceGenome:MGI:1924587
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9430025F20Rik
Summary
Enables NADP binding activity; lithocholic acid binding activity; and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in steroid metabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1); AKR1C2 (aldo-keto reductase family 1 member C2); and AKR1C3 (aldo-keto reductase family 1 member C3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward kidney adult (RPKM 66.8) See more
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Genomic context

See Akr1c21 in Genome Data Viewer
Location:
13 A1; 13 2.56 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (4624074..4636542)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (4574075..4586543)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member C20 Neighboring gene STARR-seq mESC enhancer starr_33513 Neighboring gene predicted gene, 40657 Neighboring gene STARR-seq mESC enhancer starr_33514 Neighboring gene aldo-keto reductase family 1, member E1 Neighboring gene ribosomal protein L29, pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC102401

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables 17-beta-ketosteroid reductase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables 5alpha-androstane-3beta,17beta-diol dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables NADP+ binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables NADPH binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables alditol:NADP+ 1-oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables alditol:NADP+ 1-oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
enables aldo-keto reductase (NADP) activity ISA
Inferred from Sequence Alignment
more info
PubMed 
enables androsterone dehydrogenase (B-specific) activity ISO
Inferred from Sequence Orthology
more info
 
enables androsterone dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables androsterone dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables androsterone dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables bile acid binding ISO
Inferred from Sequence Orthology
more info
 
enables carboxylic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables chlordecone reductase activity ISO
Inferred from Sequence Orthology
more info
 
enables ketosteroid monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ketosteroid monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables lithocholic acid binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
Inferred from Sequence Orthology
more info
 
enables phenanthrene 9,10-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables retinal dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables steroid binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables steroid dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IDA
Inferred from Direct Assay
more info
PubMed 
enables steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to jasmonic acid stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in daunorubicin metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in doxorubicin metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within steroid biosynthetic process ISA
Inferred from Sequence Alignment
more info
PubMed 
involved_in steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in steroid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
aldo-keto reductase family 1 member C21
Names
17-alpha-HSD
17-alpha-hydroxysteroid dehydrogenase
3(17)alpha-hydroxysteroid dehydrogenase
3(or 17)-alpha-hydroxysteroid dehydrogenase
3-alpha-hydroxysteroid dehydrogenase
DD1
DD3
dihydrodiol dehydrogenase type 1
dihydrodiol dehydrogenase type 3
NP_084177.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029901.2NP_084177.2  aldo-keto reductase family 1 member C21

    See identical proteins and their annotated locations for NP_084177.2

    Status: VALIDATED

    Source sequence(s)
    AI035317, AI882115, AY742217, BY721648
    Consensus CDS
    CCDS26225.1
    UniProtKB/Swiss-Prot
    Q6P8V0, Q91WR5, Q9CX32
    Related
    ENSMUSP00000021628.4, ENSMUST00000021628.4
    Conserved Domains (1) summary
    cd19108
    Location:6308
    AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    4624074..4636542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)