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ZNF175 zinc finger protein 175 [ Homo sapiens (human) ]

Gene ID: 7728, updated on 11-Jun-2021

Summary

Official Symbol
ZNF175provided by HGNC
Official Full Name
zinc finger protein 175provided by HGNC
Primary source
HGNC:HGNC:12964
See related
Ensembl:ENSG00000105497 MIM:601139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OTK18
Expression
Ubiquitous expression in thyroid (RPKM 3.4), ovary (RPKM 3.2) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF175 in Genome Data Viewer
Location:
19q13.41
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (51571283..51592510)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52074536..52095763)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene sialic acid binding Ig like lectin 28, pseudogene Neighboring gene sialic acid binding Ig like lectin 29, pseudogene Neighboring gene long intergenic non-protein coding RNA 1530 Neighboring gene cytosolic thiouridylase subunit 1 homolog (S. pombe) pseudogene Neighboring gene sialic acid binding Ig like lectin 5 Neighboring gene ribosomal protein L9 pseudogene 33

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat OTK18 suppresses HIV-1 Tat-induced LTR promoter activity. The Kruppel-associated box (amino acids 1-115) and zinc finger regions (amino acids 300-711) of OTK18 are responsible for the transcriptional suppressive activities PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 175
Names
zinc finger protein OTK18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007147.4NP_009078.1  zinc finger protein 175

    See identical proteins and their annotated locations for NP_009078.1

    Status: VALIDATED

    Source sequence(s)
    AC018755, AW500087, BC052997, BX474148, DB528741
    Consensus CDS
    CCDS12837.1
    UniProtKB/Swiss-Prot
    Q9Y473
    Related
    ENSP00000262259.2, ENST00000262259.7
    Conserved Domains (3) summary
    smart00349
    Location:2785
    KRAB; krueppel associated box
    COG5048
    Location:275689
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:505525
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_136208.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AW500087, BC007778, BX474148
    Related
    ENST00000545217.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    51571283..51592510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027249.2XP_016882738.1  zinc finger protein 175 isoform X1

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