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ZNF174 zinc finger protein 174 [ Homo sapiens (human) ]

Gene ID: 7727, updated on 23-Nov-2021

Summary

Official Symbol
ZNF174provided by HGNC
Official Full Name
zinc finger protein 174provided by HGNC
Primary source
HGNC:HGNC:12963
See related
Ensembl:ENSG00000103343 MIM:603900
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZSCAN8
Summary
This gene encodes a protein with three Cys2-His2-type zinc fingers in the carboxy-terminus, a putative nuclear localization signal, and an amino-terminus SCAN box which forms homodimers. This protein is believed to function as a transcriptional repressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016]
Expression
Ubiquitous expression in ovary (RPKM 4.6), testis (RPKM 4.4) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF174 in Genome Data Viewer
Location:
16p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (3401215..3409364)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3451215..3459364)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371059 Neighboring gene MT-RNR2 like 4 (pseudogene) Neighboring gene MT-ND1 pseudogene 8 Neighboring gene zinc finger and SCAN domain containing 32 Neighboring gene zinc finger protein 597 Neighboring gene N-alpha-acetyltransferase 60, NatF catalytic subunit Neighboring gene microRNA 6126

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: NAA60

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
zinc finger protein 174
Names
AW-1
zinc finger and SCAN domain-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053015.1 RefSeqGene

    Range
    5026..13175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001032292.3NP_001027463.1  zinc finger protein 174 isoform b

    See identical proteins and their annotated locations for NP_001027463.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternative 3' terminal exon compared to transcript variant 1, resulting in a shorter isoform (b) with a different C-terminus compared to isoform a.
    Source sequence(s)
    AC025283, BC001161, BI918471, DA962432
    Consensus CDS
    CCDS32380.1
    UniProtKB/Swiss-Prot
    Q15697
    Related
    ENSP00000339781.5, ENST00000344823.9
    Conserved Domains (1) summary
    smart00431
    Location:42152
    SCAN; leucine rich region
  2. NM_001347868.2NP_001334797.1  zinc finger protein 174 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a segment of the 5' UTR, compared to transcript variant 1, but encodes the same isoform (a).
    Source sequence(s)
    AC025283, BM969505
    Consensus CDS
    CCDS10504.1
    UniProtKB/Swiss-Prot
    Q15697
    Related
    ENSP00000460397.1, ENST00000571936.5
  3. NM_001347869.2NP_001334798.1  zinc finger protein 174 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternative 3' terminal exon compared to transcript variant 1, resulting in a shorter isoform (c) with a different C-terminus compared to isoform a.
    Source sequence(s)
    AC025283
    Consensus CDS
    CCDS86501.1
    UniProtKB/TrEMBL
    I3L2H2
    Related
    ENSP00000459681.1, ENST00000572544.1
  4. NM_001347870.2NP_001334799.1  zinc finger protein 174 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks a segment of the 5' UTR and contains an alternative 3' terminal exon, compared to transcript variant 1, resulting in a shorter isoform (c) with a different C-terminus compared to isoform a.
    Source sequence(s)
    AC025283
    Consensus CDS
    CCDS86501.1
    UniProtKB/TrEMBL
    I3L2H2
  5. NM_003450.3NP_003441.1  zinc finger protein 174 isoform a

    See identical proteins and their annotated locations for NP_003441.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC025283, BI918471, BM969505, DA962432, U31248
    Consensus CDS
    CCDS10504.1
    UniProtKB/Swiss-Prot
    Q15697
    Related
    ENSP00000268655.4, ENST00000268655.5
    Conserved Domains (6) summary
    smart00431
    Location:42152
    SCAN; leucine rich region
    COG5048
    Location:352407
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:328348
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:326348
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:42130
    SCAN; SCAN domain
    pfam13465
    Location:369393
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    3401215..3409364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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