Format

Send to:

Choose Destination

VEZF1 vascular endothelial zinc finger 1 [ Homo sapiens (human) ]

Gene ID: 7716, updated on 12-Aug-2018

Summary

Official Symbol
VEZF1provided by HGNC
Official Full Name
vascular endothelial zinc finger 1provided by HGNC
Primary source
HGNC:HGNC:12949
See related
Ensembl:ENSG00000136451 MIM:606747; Vega:OTTHUMG00000178777
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DB1; ZNF161
Summary
Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. ZNF161 is a C2H2-type zinc finger protein (Koyano-Nakagawa et al., 1994 [PubMed 8035792]). See MIM 603971 for general information on zinc finger proteins.[supplied by OMIM, Sep 2008]
Expression
Ubiquitous expression in thyroid (RPKM 19.6), endometrium (RPKM 18.2) and 25 other tissues See more
Orthologs

Genomic context

See VEZF1 in Genome Data Viewer
Location:
17q22
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (57971547..57988264, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (56048908..56065615, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S23 Neighboring gene CUE domain containing 1 Neighboring gene uncharacterized LOC107985065 Neighboring gene uncharacterized LOC101929185 Neighboring gene serine and arginine rich splicing factor 1 Neighboring gene uncharacterized LOC105371840

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cellular defense response TAS
Traceable Author Statement
more info
PubMed 
endothelial cell development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
vascular endothelial zinc finger 1
Names
putative transcription factor DB1
zinc finger protein 161

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330393.1NP_001317322.1  vascular endothelial zinc finger 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC015813, BU729102
    Consensus CDS
    CCDS82169.1
    UniProtKB/TrEMBL
    J3QSH4
  2. NM_007146.2NP_009077.2  vascular endothelial zinc finger 1 isoform 1

    See identical proteins and their annotated locations for NP_009077.2

    Status: VALIDATED

    Source sequence(s)
    AA195154, BG718897, BX648862, D28118
    Consensus CDS
    CCDS32687.1
    UniProtKB/Swiss-Prot
    Q14119
    Related
    ENSP00000462337.1, OTTHUMP00000260036, ENST00000581208.1, OTTHUMT00000443321
    Conserved Domains (2) summary
    sd00017
    Location:176196
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:188213
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    57971547..57988264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257643.1XP_005257700.1  vascular endothelial zinc finger 1 isoform X1

    Conserved Domains (2) summary
    sd00017
    Location:176196
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:188213
    zf-H2C2_2; Zinc-finger double domain
  2. XM_005257644.5XP_005257701.1  vascular endothelial zinc finger 1 isoform X2

    See identical proteins and their annotated locations for XP_005257701.1

    Conserved Domains (2) summary
    sd00017
    Location:167187
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:179204
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017025018.1XP_016880507.1  vascular endothelial zinc finger 1 isoform X3

    UniProtKB/TrEMBL
    J3QSH4
    Related
    ENSP00000464687.1, OTTHUMP00000260035, ENST00000584396.5, OTTHUMT00000443320
    Conserved Domains (2) summary
    sd00017
    Location:167187
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:179204
    zf-H2C2_2; Zinc-finger double domain
Support Center