Hnrnpa0 heterogeneous nuclear ribonucleoprotein A0 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hnrnpa0provided by MGI
Official Full Name: heterogeneous nuclear ribonucleoprotein A0provided by MGI
Primary source: MGI:MGI:1924384
See related: Ensembl:ENSMUSG00000007836 AllianceGenome:MGI:1924384
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hnrpa0; hnRNP A0; 1110055B05Rik; 3010025E17Rik
Summary: Enables mRNA 3'-UTR AU-rich region binding activity. Involved in 3'-UTR-mediated mRNA stabilization; inflammatory response; and response to lipopolysaccharide. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in 3rd ventricle; 4th ventricle; brain; brain ventricular layer; and telencephalon ventricular layer. Orthologous to human HNRNPA0 (heterogeneous nuclear ribonucleoprotein A0). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 13; 13 B1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (58273693..58276370, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (58125879..58128556, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of Hnrnpa0, a del(5q) gene, alters myeloid cell fate in murine cells through regulation of AU-rich transcripts.
Title: Knockdown of Hnrnpa0, a del(5q) gene, alters myeloid cell fate in murine cells through regulation of AU-rich transcripts.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA858784 (e-PCR)
- UniSTS:261227

UniSTS:479131 (e-PCR)
- UniSTS:479131

Hnrpa0 (e-PCR), detects polymorphism
- UniSTS:479131

RH79130 (e-PCR)
- UniSTS:81098

Homology

Homologs of the Hnrnpa0 gene: The Hnrnpa0 gene is conserved in human, cow, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 332 organisms have orthologs with human gene Hnrnpa0
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR AU-rich region binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR AU-rich region binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA stabilization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in 3'-UTR-mediated mRNA stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoprotein A0

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029872.1 → NP_084148.1 heterogeneous nuclear ribonucleoprotein A0

See identical proteins and their annotated locations for NP_084148.1

Status: VALIDATED

Source sequence(s)

AC165251

Consensus CDS

CCDS49280.1

UniProtKB/Swiss-Prot

Q9CX86

Related

ENSMUSP00000007980.7, ENSMUST00000007980.7

Conserved Domains (3) summary

pfam11627
Location:253 → 272

HnRNPA1; Nuclear factor hnRNPA1

cd12326
Location:5 → 83

RRM1_hnRNPA0; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0) and similar proteins

cl17169
Location:99 → 178

RRM_SF; RNA recognition motif (RRM) superfamily