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Crebrf CREB3 regulatory factor [ Mus musculus (house mouse) ]

Gene ID: 77128, updated on 11-Apr-2024

Summary

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Official Symbol
Crebrfprovided by MGI
Official Full Name
CREB3 regulatory factorprovided by MGI
Primary source
MGI:MGI:1924378
See related
Ensembl:ENSMUSG00000048249 AllianceGenome:MGI:1924378
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LRF; A930001N09Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within maternal behavior; negative regulation of glucocorticoid mediated signaling pathway; and positive regulation of prolactin signaling pathway. Located in nuclear body. Is expressed in blastocyst; early embryo; polar body; and uterus. Orthologous to human CREBRF (CREB3 regulatory factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 4.4), cerebellum adult (RPKM 3.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 13.5 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26918716..26995611)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26715594..26776637)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene endoplasmic reticulum-golgi intermediate compartment 1 Neighboring gene predicted gene, 41553 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit E Neighboring gene STARR-positive B cell enhancer ABC_E3193 Neighboring gene STARR-positive B cell enhancer ABC_E2474 Neighboring gene STARR-positive B cell enhancer ABC_E8660 Neighboring gene BCL2/adenovirus E1B interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_42133 Neighboring gene STARR-seq mESC enhancer starr_42134 Neighboring gene NK2 homeobox 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Limited Metabolic Effect of the CREBRF(R457Q) Obesity Variant in Mice. Metcalfe LK, et al. Cells, 2022 Jan 31. PMID 35159305, Free PMC Article
  2. Molecular characterization of mouse CREB3 regulatory factor in Neuro2a cells. Oh-Hashi K, et al. Mol Biol Rep, 2021 Jul. PMID 34275032
  3. Loss of CREBRF Reduces Anxiety-like Behaviors and Circulating Glucocorticoids in Male and Female Mice. Frahm KA, et al. Endocrinology, 2020 Nov 1. PMID 32901804, Free PMC Article
  4. Expression pattern implicates a potential role for luman recruitment factor in the process of implantation in uteri and development of preimplantation embryos in mice. Yang Y, et al. J Reprod Dev, 2013. PMID 23400243, Free PMC Article
  5. A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress. Kanshana JS, et al. PLoS One, 2021. PMID 34520472, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Limited Metabolic Effect of the CREBRF(R457Q) Obesity Variant in Mice.
    Title: Limited Metabolic Effect of the CREBRF(R457Q) Obesity Variant in Mice.
  2. Molecular characterization of mouse CREB3 regulatory factor in Neuro2a cells.
    Title: Molecular characterization of mouse CREB3 regulatory factor in Neuro2a cells.
  3. A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress.
    Title: A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress.
  4. Loss of CREBRF Reduces Anxiety-like Behaviors and Circulating Glucocorticoids in Male and Female Mice.
    Title: Loss of CREBRF Reduces Anxiety-like Behaviors and Circulating Glucocorticoids in Male and Female Mice.
  5. LRF has a role in the process of implantation in uteri and development of preimplantation embryos in mice
    Title: Expression pattern implicates a potential role for luman recruitment factor in the process of implantation in uteri and development of preimplantation embryos in mice.
  6. postulate that LRF plays a critical role in the attenuation of the HPA axis through repression of glucocorticoid stress signaling during parturition and the postpartum period
    Title: Luman/CREB3 recruitment factor regulates glucocorticoid receptor activity and is essential for prolactin-mediated maternal instinct.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within maternal behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within maternal behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of glucocorticoid mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of glucocorticoid mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of prolactin signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
involved_in response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CREB3 regulatory factor
Names
UPF0474 protein C5orf41 homolog
luman recruitment factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029870.2 → NP_084146.1  CREB3 regulatory factor

    See identical proteins and their annotated locations for NP_084146.1

    Status: VALIDATED

    Source sequence(s)
    AK030092, CT025550
    Consensus CDS
    CCDS37516.1
    UniProtKB/Swiss-Prot
    B8JJI1, Q14DI2, Q8C8N7, Q8CDG5, Q9CTQ7
    UniProtKB/TrEMBL
    B8JJI2
    Related
    ENSMUSP00000059102.8, ENSMUST00000062519.14
    Conserved Domains (1) summary
    cd14809
    Location:526 → 564
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    26918716..26995611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160833.1 → XP_036016726.1  CREB3 regulatory factor isoform X1

    UniProtKB/Swiss-Prot
    B8JJI1, Q14DI2, Q8C8N7, Q8CDG5, Q9CTQ7
    UniProtKB/TrEMBL
    B8JJI2
    Conserved Domains (1) summary
    cd14809
    Location:526 → 564
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

  2. XM_011246717.4 → XP_011245019.2  CREB3 regulatory factor isoform X1

    UniProtKB/Swiss-Prot
    B8JJI1, Q14DI2, Q8C8N7, Q8CDG5, Q9CTQ7
    UniProtKB/TrEMBL
    B8JJI2
    Conserved Domains (1) summary
    cd14809
    Location:526 → 564
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

  3. XM_036160838.1 → XP_036016731.1  CREB3 regulatory factor isoform X3

    UniProtKB/TrEMBL
    B8JJI2
    Conserved Domains (1) summary
    cd14809
    Location:484 → 522
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

  4. XM_017317723.3 → XP_017173212.1  CREB3 regulatory factor isoform X1

    UniProtKB/Swiss-Prot
    B8JJI1, Q14DI2, Q8C8N7, Q8CDG5, Q9CTQ7
    UniProtKB/TrEMBL
    B8JJI2
    Conserved Domains (1) summary
    cd14809
    Location:526 → 564
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

  5. XM_036160837.1 → XP_036016730.1  CREB3 regulatory factor isoform X2

    UniProtKB/TrEMBL
    B8JJI2
    Related
    ENSMUSP00000114274.2, ENSMUST00000142539.8
    Conserved Domains (1) summary
    cd14809
    Location:518 → 556
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

  6. XM_036160836.1 → XP_036016729.1  CREB3 regulatory factor isoform X1

    UniProtKB/Swiss-Prot
    B8JJI1, Q14DI2, Q8C8N7, Q8CDG5, Q9CTQ7
    UniProtKB/TrEMBL
    B8JJI2
    Conserved Domains (1) summary
    cd14809
    Location:526 → 564
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

  7. XM_036160839.1 → XP_036016732.1  CREB3 regulatory factor isoform X3

    UniProtKB/TrEMBL
    B8JJI2
    Conserved Domains (1) summary
    cd14809
    Location:484 → 522
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

  8. XM_036160834.1 → XP_036016727.1  CREB3 regulatory factor isoform X1

    UniProtKB/Swiss-Prot
    B8JJI1, Q14DI2, Q8C8N7, Q8CDG5, Q9CTQ7
    UniProtKB/TrEMBL
    B8JJI2
    Conserved Domains (1) summary
    cd14809
    Location:526 → 564
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

  9. XM_036160835.1 → XP_036016728.1  CREB3 regulatory factor isoform X1

    UniProtKB/Swiss-Prot
    B8JJI1, Q14DI2, Q8C8N7, Q8CDG5, Q9CTQ7
    UniProtKB/TrEMBL
    B8JJI2
    Conserved Domains (1) summary
    cd14809
    Location:526 → 564
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

  10. XM_036160840.1 → XP_036016733.1  CREB3 regulatory factor isoform X4

    UniProtKB/TrEMBL
    B8JJI2
    Conserved Domains (1) summary
    cd14809
    Location:478 → 516
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CDG5.1 GenPept UniProtKB/Swiss-Prot:Q8CDG5

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