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Il33 interleukin 33 [ Mus musculus (house mouse) ]

Gene ID: 77125, updated on 22-Nov-2021

Summary

Official Symbol
Il33provided by MGI
Official Full Name
interleukin 33provided by MGI
Primary source
MGI:MGI:1924375
See related
Ensembl:ENSMUSG00000024810
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Il-33; Il1f11; NF-HEV; 9230117N10Rik
Expression
Broad expression in lung adult (RPKM 13.9), cerebellum adult (RPKM 10.6) and 19 other tissues See more
Orthologs
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Genomic context

See Il33 in Genome Data Viewer
Location:
19; 19 C1
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (29902513..29938118)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (29925113..29960718)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (29999604..30035205)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RAN binding protein 6 Neighboring gene predicted gene, 41832 Neighboring gene predicted gene, 36209 Neighboring gene predicted gene, 26046 Neighboring gene tumor protein D52-like 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-33 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in interleukin-33-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in macrophage activation involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in microglial cell activation involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in microglial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of T-helper 1 type immune response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of immunoglobulin production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of interferon-gamma production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of leukocyte migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of macrophage proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of CD80 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of CD86 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of MHC class I biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of MHC class II biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cellular defense response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of chemokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of immunoglobulin production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-13 production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of interleukin-4 production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of interleukin-5 production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-6 production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of macrophage activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of macrophage activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of macrophage activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of nitric-oxide synthase biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of type 2 immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of type 2 immune response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
interleukin-33
Names
nuclear factor from high endothelial venules

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164724.2NP_001158196.1  interleukin-33

    See identical proteins and their annotated locations for NP_001158196.1

    Status: VALIDATED

    Source sequence(s)
    AC111048, AK075849, AK163464, CJ191135
    Consensus CDS
    CCDS29740.1
    UniProtKB/Swiss-Prot
    Q8BVZ5
    Related
    ENSMUSP00000025724.9, ENSMUST00000025724.9
    Conserved Domains (1) summary
    pfam15095
    Location:5264
    IL33; Interleukin 33
  2. NM_001360725.1NP_001347654.1  interleukin-33

    Status: VALIDATED

    Source sequence(s)
    AC111048, AC157785
    Consensus CDS
    CCDS29740.1
    Conserved Domains (1) summary
    pfam15095
    Location:5264
    IL33; Interleukin 33
  3. NM_133775.3NP_598536.2  interleukin-33

    See identical proteins and their annotated locations for NP_598536.2

    Status: VALIDATED

    Source sequence(s)
    AC111048, AC157785, AK163464
    Consensus CDS
    CCDS29740.1
    UniProtKB/Swiss-Prot
    Q8BVZ5
    Related
    ENSMUSP00000113829.3, ENSMUST00000120388.9
    Conserved Domains (1) summary
    pfam15095
    Location:5264
    IL33; Interleukin 33

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    29902513..29938118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161730.1XP_036017623.1  interleukin-33 isoform X1

    Conserved Domains (1) summary
    pfam15095
    Location:5264
    IL33; Interleukin 33
  2. XM_006527463.4XP_006527526.1  interleukin-33 isoform X1

    See identical proteins and their annotated locations for XP_006527526.1

    UniProtKB/Swiss-Prot
    Q8BVZ5
    Conserved Domains (1) summary
    pfam15095
    Location:5264
    IL33; Interleukin 33
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