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ZNF154 zinc finger protein 154 [ Homo sapiens (human) ]

Gene ID: 7710, updated on 9-Oct-2022

Summary

Official Symbol
ZNF154provided by HGNC
Official Full Name
zinc finger protein 154provided by HGNC
Primary source
HGNC:HGNC:12939
See related
Ensembl:ENSG00000179909 MIM:604085; AllianceGenome:HGNC:12939
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
pHZ-92
Summary
This gene encodes a protein that belongs to the zinc finger Kruppel family of transcriptional regulators, whose members are thought to function in normal and abnormal cell growth and differentiation. Hypermethylation of this gene is associated with the recurrence of non muscle invasive bladder cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Expression
Ubiquitous expression in thyroid (RPKM 3.0), spleen (RPKM 2.6) and 24 other tissues See more
Orthologs
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Genomic context

See ZNF154 in Genome Data Viewer
Location:
19q13.43
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57696275..57709204, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60793207..60806134, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58207643..58220572, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 4 Neighboring gene tumor protein p63 regulated 1 like pseudogene 1 Neighboring gene zinc finger protein 551 Neighboring gene uncharacterized LOC124904783 Neighboring gene zinc finger protein 671

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC176628, MGC176661

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034060.1 RefSeqGene

    Range
    5008..17937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001085384.3NP_001078853.1  zinc finger protein 154

    See identical proteins and their annotated locations for NP_001078853.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
    Source sequence(s)
    AC004017, CN280337, U20648
    Consensus CDS
    CCDS42639.1
    UniProtKB/Swiss-Prot
    Q13106, Q8NAR0
    UniProtKB/TrEMBL
    A0A024R4Q0
    Related
    ENSP00000507206.1, ENST00000684351.1
    Conserved Domains (5) summary
    smart00349
    Location:1462
    KRAB; krueppel associated box
    COG5048
    Location:139436
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:359379
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:371396
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_110974.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' structure compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB095924, AC004017, CN280337
  2. NR_110975.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' structure compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC003006, AC004017, AK092261, CN280337

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    57696275..57709204 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439369.1XP_047295325.1  zinc finger protein 154 isoform X1

RNA

  1. XR_007066986.1 RNA Sequence

  2. XR_007066984.1 RNA Sequence

  3. XR_007066985.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    60793207..60806134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_003444.1: Suppressed sequence

    Description
    NM_003444.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.