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Ints7 integrator complex subunit 7 [ Mus musculus (house mouse) ]

Gene ID: 77065, updated on 26-Sep-2022

Summary

Official Symbol
Ints7provided by MGI
Official Full Name
integrator complex subunit 7provided by MGI
Primary source
MGI:MGI:1924315
See related
Ensembl:ENSMUSG00000037461 AllianceGenome:MGI:1924315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
int7; 5930412E23Rik
Summary
Predicted to be involved in DNA damage checkpoint signaling; cellular response to ionizing radiation; and snRNA 3'-end processing. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be located in chromosome; cytoplasm; and nuclear body. Predicted to be part of integrator complex. Is expressed in central nervous system; retina; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human INTS7 (integrator complex subunit 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 15.5), thymus adult (RPKM 13.6) and 28 other tissues See more
Orthologs
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Genomic context

See Ints7 in Genome Data Viewer
Location:
1; 1 H6
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (191307652..191355802)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (191575540..191623690)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32200 Neighboring gene predicted gene, 32334 Neighboring gene denticleless E3 ubiquitin protein ligase Neighboring gene predicted gene, 39741 Neighboring gene lysophosphatidylglycerol acyltransferase 1 Neighboring gene predicted gene, 22446

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in snRNA processing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of integrator complex ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
integrator complex subunit 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306203.1NP_001293132.1  integrator complex subunit 7 isoform 2

    See identical proteins and their annotated locations for NP_001293132.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Both variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC132830, AK020029, AK052103, AK085336, AK086462, BP758668, CD348032, CK635124
    UniProtKB/Swiss-Prot
    Q7TQK1
  2. NM_001306204.1NP_001293133.1  integrator complex subunit 7 isoform 2

    See identical proteins and their annotated locations for NP_001293133.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two exons in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Both variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC132830, AK020029, AK052103, AK086462, BP758668, CD348032, CK635124
    UniProtKB/Swiss-Prot
    Q7TQK1
  3. NM_178632.6NP_848747.4  integrator complex subunit 7 isoform 1

    See identical proteins and their annotated locations for NP_848747.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC132830, AK020029, AK052103, AK086462, BP758668, CD348032, CK635124
    Consensus CDS
    CCDS35825.1
    UniProtKB/Swiss-Prot
    Q7TQK1
    UniProtKB/TrEMBL
    A0A0R4J0E4
    Related
    ENSMUSP00000036277.6, ENSMUST00000045450.7

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    191307652..191355802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_865812.3 RNA Sequence