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ZNF146 zinc finger protein 146 [ Homo sapiens (human) ]

Gene ID: 7705, updated on 6-Sep-2022

Summary

Official Symbol
ZNF146provided by HGNC
Official Full Name
zinc finger protein 146provided by HGNC
Primary source
HGNC:HGNC:12931
See related
Ensembl:ENSG00000167635 MIM:601505; AllianceGenome:HGNC:12931
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OZF
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 20.8), endometrium (RPKM 19.9) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF146 in Genome Data Viewer
Location:
19q13.12
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36214723..36238768)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (38763513..38787183)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36706008..36729670)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene calpain small subunit 1 Neighboring gene cytochrome c oxidase subunit 7A1 Neighboring gene zinc finger protein 565 Neighboring gene uncharacterized LOC107985304 Neighboring gene uncharacterized LOC124904707 Neighboring gene uncharacterized LOC100134317

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC125660, MGC125661

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding TAS
Traceable Author Statement
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heparin binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein OZF
Names
only zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099638.2NP_001093108.1  zinc finger protein OZF

    See identical proteins and their annotated locations for NP_001093108.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AI039686, BC065568, DA645504, DA806687, DR155969
    Consensus CDS
    CCDS12492.1
    UniProtKB/Swiss-Prot
    Q15072, Q2TB94
    Related
    ENSP00000400391.1, ENST00000456324.5
    Conserved Domains (3) summary
    COG5048
    Location:1260
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:7494
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255279
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001099639.2NP_001093109.1  zinc finger protein OZF

    See identical proteins and their annotated locations for NP_001093109.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AI039686, BC065568, CN409203, DA645504, DB068031, DR155969
    Consensus CDS
    CCDS12492.1
    UniProtKB/Swiss-Prot
    Q15072, Q2TB94
    Conserved Domains (3) summary
    COG5048
    Location:1260
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:7494
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255279
    zf-H2C2_2; Zinc-finger double domain
  3. NM_007145.3NP_009076.2  zinc finger protein OZF

    See identical proteins and their annotated locations for NP_009076.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AI039686, BC065568, DA395000, DA645504, DR155969
    Consensus CDS
    CCDS12492.1
    UniProtKB/Swiss-Prot
    Q15072, Q2TB94
    Related
    ENSP00000392095.1, ENST00000443387.3
    Conserved Domains (3) summary
    COG5048
    Location:1260
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:7494
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255279
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    36214723..36238768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439366.1XP_047295322.1  zinc finger protein OZF isoform X1

    UniProtKB/Swiss-Prot
    Q2TB94
  2. XM_017027247.3XP_016882736.1  zinc finger protein OZF isoform X1

    UniProtKB/Swiss-Prot
    Q15072, Q2TB94
    Conserved Domains (3) summary
    COG5048
    Location:1260
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:7494
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255279
    zf-H2C2_2; Zinc-finger double domain
  3. XM_047439367.1XP_047295323.1  zinc finger protein OZF isoform X1

    UniProtKB/Swiss-Prot
    Q2TB94
  4. XM_047439365.1XP_047295321.1  zinc finger protein OZF isoform X1

    UniProtKB/Swiss-Prot
    Q2TB94
  5. XM_017027246.3XP_016882735.1  zinc finger protein OZF isoform X1

    UniProtKB/Swiss-Prot
    Q15072, Q2TB94
    Conserved Domains (3) summary
    COG5048
    Location:1260
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:7494
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255279
    zf-H2C2_2; Zinc-finger double domain
  6. XM_047439368.1XP_047295324.1  zinc finger protein OZF isoform X1

    UniProtKB/Swiss-Prot
    Q2TB94
  7. XM_005259214.4XP_005259271.1  zinc finger protein OZF isoform X1

    See identical proteins and their annotated locations for XP_005259271.1

    UniProtKB/Swiss-Prot
    Q15072, Q2TB94
    Conserved Domains (3) summary
    COG5048
    Location:1260
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:7494
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255279
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    38763513..38787183
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)