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Mrap melanocortin 2 receptor accessory protein [ Mus musculus (house mouse) ]

Gene ID: 77037, updated on 1-Mar-2024

Summary

Official Symbol
Mrapprovided by MGI
Official Full Name
melanocortin 2 receptor accessory proteinprovided by MGI
Primary source
MGI:MGI:1924287
See related
Ensembl:ENSMUSG00000039956 AllianceGenome:MGI:1924287
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Falp; ORF61; C21ORF61; 1110025G12Rik
Summary
Predicted to enable identical protein binding activity; melanocortin receptor binding activity; and signaling receptor regulator activity. Acts upstream of or within brown fat cell differentiation. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including brain; olfactory epithelium; respiratory system; salivary gland; and urinary system. Used to study adrenal gland disease. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human MRAP (melanocortin 2 receptor accessory protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 314.9), subcutaneous fat pad adult (RPKM 188.2) and 6 other tissues See more
Orthologs
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Genomic context

See Mrap in Genome Data Viewer
Location:
16 C3.3; 16 51.9 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (90535095..90546673)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (90738207..90749785)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr16:90727472-90727773 Neighboring gene MIS18 kinetochore protein A Neighboring gene predicted gene, 17518 Neighboring gene URB1 ribosome biogenesis 1 homolog (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_41464 Neighboring gene STARR-positive B cell enhancer ABC_E1929 Neighboring gene eva-1 homolog C Neighboring gene predicted gene, 36363

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables corticotropin hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables corticotropin hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables type 1 melanocortin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables type 1 melanocortin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables type 3 melanocortin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables type 3 melanocortin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables type 4 melanocortin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables type 4 melanocortin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables type 5 melanocortin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables type 5 melanocortin receptor binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
melanocortin-2 receptor accessory protein
Names
fat cell-specific low molecular weight protein
fat tissue-specific low MW protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029844.4NP_084120.1  melanocortin-2 receptor accessory protein

    See identical proteins and their annotated locations for NP_084120.1

    Status: VALIDATED

    Source sequence(s)
    AC126671
    Consensus CDS
    CCDS28317.1
    UniProtKB/Swiss-Prot
    Q3TZ49, Q8R439, Q9D159
    Related
    ENSMUSP00000043890.3, ENSMUST00000038197.3
    Conserved Domains (1) summary
    pfam15183
    Location:189
    MRAP; Melanocortin-2 receptor accessory protein family

RNA

  1. NR_155757.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC126671
  2. NR_155758.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC126671
    Related
    ENSMUST00000125429.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    90535095..90546673
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)