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Arxes2 adipocyte-related X-chromosome expressed sequence 2 [ Mus musculus (house mouse) ]

Gene ID: 76976, updated on 8-Feb-2024


Official Symbol
Arxes2provided by MGI
Official Full Name
adipocyte-related X-chromosome expressed sequence 2provided by MGI
Primary source
See related
Ensembl:ENSMUSG00000048040 AllianceGenome:MGI:1924226
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Spcs3; Spc22/23; 2900062L11Rik
Acts upstream of or within fat cell differentiation. Located in endoplasmic reticulum. Is expressed in axial musculature; eye; incisor; and nervous system. Orthologous to human SPCS3 (signal peptidase complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See Arxes2 in Genome Data Viewer
X F1; X 57.35 cM
Exon count:
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (134894569..134896108)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (135993820..135995359)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor associated sorting protein 2 Neighboring gene basic helix-loop-helix domain containing, class B9 Neighboring gene STARR-seq mESC enhancer starr_47972 Neighboring gene predicted gene, 31214 Neighboring gene adipocyte-related X-chromosome expressed sequence 1 Neighboring gene predicted gene, 54084

Genomic regions, transcripts, and products

General gene information


Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
part_of signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info

General protein information

Preferred Names
adipocyte-related X-chromosome expressed sequence 2
SPase 22 kDa subunit
SPase 22/23 kDa subunit
microsomal signal peptidase 22/23 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029823.2NP_084099.1  adipocyte-related X-chromosome expressed sequence 2

    See identical proteins and their annotated locations for NP_084099.1

    Status: VALIDATED

    Source sequence(s)
    AA286632, AK077432, AV333270, BY773138
    Consensus CDS
    B1AUR7, C0HK79, C0HK80, Q8BK31, Q9D365, Q9D6F2
    ENSMUSP00000051250.8, ENSMUST00000058119.9
    Conserved Domains (1) summary
    SPC22; Signal peptidase subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000086.8 Reference GRCm39 C57BL/6J

    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_003642.1: Suppressed sequence

    NR_003642.1: This RefSeq was permanently suppressed because it is now thought that this gene encodes a protein.