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ZNF138 zinc finger protein 138 [ Homo sapiens (human) ]

Gene ID: 7697, updated on 1-Jun-2020

Summary

Official Symbol
ZNF138provided by HGNC
Official Full Name
zinc finger protein 138provided by HGNC
Primary source
HGNC:HGNC:12922
See related
Ensembl:ENSG00000197008 MIM:604080
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
pHZ-32
Expression
Ubiquitous expression in brain (RPKM 2.7), testis (RPKM 2.2) and 25 other tissues See more
Orthologs

Genomic context

See ZNF138 in Genome Data Viewer
Location:
7q11.21
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (64794428..64860823)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (64254766..64314178)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger protein 107 Neighboring gene BCL2 interacting protein 3 pseudogene 11 Neighboring gene microRNA 6839 Neighboring gene myelin protein zero like 1 pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr7.2319 Neighboring gene selenophosphate synthetase 1 pseudogene 1 Neighboring gene eukaryotic translation elongation factor 1 delta pseudogene 4 Neighboring gene uncharacterized LOC441239 Neighboring gene zinc finger protein 273

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp761D2121

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 138
Names
zinc finger protein 138 (clone pHZ-32)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160183.3NP_001153655.1  zinc finger protein 138 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes two alternate exons in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC073349
    Consensus CDS
    CCDS55115.1
    UniProtKB/Swiss-Prot
    P52744
    UniProtKB/TrEMBL
    A0A0A0MT90, A2RRP7
    Related
    ENSP00000419197.1, ENST00000494380.5
    Conserved Domains (2) summary
    smart00349
    Location:457
    KRAB; krueppel associated box
    pfam01352
    Location:443
    KRAB; KRAB box
  2. NM_001271637.2NP_001258566.1  zinc finger protein 138 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate exon, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC073349
    Consensus CDS
    CCDS64659.1
    UniProtKB/Swiss-Prot
    P52744
    UniProtKB/TrEMBL
    A2RRP7, C9JHF6
    Related
    ENSP00000415995.1, ENST00000440598.2
    Conserved Domains (2) summary
    smart00349
    Location:450
    KRAB; krueppel associated box
    pfam01352
    Location:443
    KRAB; KRAB box
  3. NM_001271638.2NP_001258567.2  zinc finger protein 138 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) includes an alternate exon, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC073349
    Consensus CDS
    CCDS64661.1
    Related
    ENSP00000399528.1, ENST00000437743.1
  4. NM_001271639.2NP_001258568.2  zinc finger protein 138 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) includes an alternate in-frame exon, compared to variant 1. The encoded isoform (6) is longer than isoform 1.
    Source sequence(s)
    AC073349
    Consensus CDS
    CCDS64660.1
    Related
    ENSP00000303533.7, ENST00000307355.11
  5. NM_001271640.2NP_001258569.1  zinc finger protein 138 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) includes an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting isoform (7) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC073349
    Consensus CDS
    CCDS75607.1
    UniProtKB/TrEMBL
    A0A0A0MRG3
    Related
    ENSP00000352770.4, ENST00000359735.7
    Conserved Domains (2) summary
    smart00349
    Location:443
    KRAB; krueppel associated box
    pfam01352
    Location:443
    KRAB; KRAB box
  6. NM_001271649.2NP_001258578.1  zinc finger protein 138 isoform 4

    See identical proteins and their annotated locations for NP_001258578.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate coding exon, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC073349
    UniProtKB/TrEMBL
    A2RRP7
    Related
    ENST00000430838.2
    Conserved Domains (2) summary
    COG5189
    Location:72155
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:5070
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. NM_001367572.1NP_001354501.1  zinc finger protein 138 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC073349
  8. NM_001367573.1NP_001354502.1  zinc finger protein 138 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC073349
  9. NM_001367574.1NP_001354503.1  zinc finger protein 138 isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variant 13, encodes isoform 10.
    Source sequence(s)
    AC073349
  10. NM_001367575.1NP_001354504.1  zinc finger protein 138 isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variant 12, encodes isoform 10.
    Source sequence(s)
    AC073349
  11. NM_001367576.1NP_001354505.1  zinc finger protein 138 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC073349
  12. NM_001367577.1NP_001354506.1  zinc finger protein 138 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC073349
  13. NM_006524.4NP_006515.3  zinc finger protein 138 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC073349
    Consensus CDS
    CCDS34645.2
    Related
    ENSP00000407262.2, ENST00000440155.6

RNA

  1. NR_073389.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an exon, and includes an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AC073349
  2. NR_073391.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) includes two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC073349
  3. NR_160268.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073349
  4. NR_160269.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073349
  5. NR_160270.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073349
  6. NR_160271.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073349

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    64794428..64860823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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