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Chmp5 charged multivesicular body protein 5 [ Mus musculus (house mouse) ]

Gene ID: 76959, updated on 8-May-2024

Summary

Official Symbol
Chmp5provided by MGI
Official Full Name
charged multivesicular body protein 5provided by MGI
Primary source
MGI:MGI:1924209
See related
Ensembl:ENSMUSG00000028419 AllianceGenome:MGI:1924209
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2210412K09Rik
Summary
Acts upstream of or within endosome to lysosome transport; lysosome organization; and regulation of receptor recycling. Located in nucleus. Is expressed in telencephalon. Orthologous to human CHMP5 (charged multivesicular body protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 44.1), bladder adult (RPKM 43.3) and 24 other tissues See more
Orthologs
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Genomic context

See Chmp5 in Genome Data Viewer
Location:
4 A5; 4 20.69 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (40948553..40965302)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (40948553..40965302)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene serine peptidase inhibitor, Kazal type 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:40895401-40895689 Neighboring gene BCL2-associated athanogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E3485 Neighboring gene predicted gene, 52692 Neighboring gene nuclear transcription factor, X-box binding 1 Neighboring gene microRNA 3094 Neighboring gene aquaporin 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in autophagosome maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to muramyl dipeptide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endosome to lysosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within erythrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in late endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within lysosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane fission NAS
Non-traceable Author Statement
more info
PubMed 
involved_in midbody abscission ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
 
involved_in multivesicular body assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in multivesicular body-lysosome fusion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in multivesicular body-lysosome fusion TAS
Traceable Author Statement
more info
PubMed 
involved_in nuclear membrane reassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleus organization ISO
Inferred from Sequence Orthology
more info
 
involved_in plasma membrane repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of centrosome duplication ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of receptor recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in vacuolar transport IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle budding from membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in vesicle fusion with vacuole NAS
Non-traceable Author Statement
more info
PubMed 
involved_in viral budding ISO
Inferred from Sequence Orthology
more info
 
involved_in viral budding from plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in viral budding via host ESCRT complex ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in amphisome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in autophagosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
is_active_in multivesicular body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in multivesicular body membrane ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
charged multivesicular body protein 5
Names
SNF7 domain-containing protein 2
chromatin modifying protein 5
likely ortholog of H. sapiens SNF7 domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029814.1NP_084090.1  charged multivesicular body protein 5

    See identical proteins and their annotated locations for NP_084090.1

    Status: PROVISIONAL

    Source sequence(s)
    AK008911
    Consensus CDS
    CCDS18053.1
    UniProtKB/Swiss-Prot
    Q3UI64, Q9D7S9
    Related
    ENSMUSP00000030128.6, ENSMUST00000030128.6
    Conserved Domains (1) summary
    cl21588
    Location:1201
    Snf7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    40948553..40965302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)