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ZNF135 zinc finger protein 135 [ Homo sapiens (human) ]

Gene ID: 7694, updated on 11-Jun-2021

Summary

Official Symbol
ZNF135provided by HGNC
Official Full Name
zinc finger protein 135provided by HGNC
Primary source
HGNC:HGNC:12919
See related
Ensembl:ENSG00000176293 MIM:604077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
pT3; ZNF61; pHZ-17; ZNF78L1
Expression
Broad expression in ovary (RPKM 3.4), endometrium (RPKM 3.3) and 24 other tissues See more
Orthologs
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Genomic context

See ZNF135 in Genome Data Viewer
Location:
19q13.43
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (58059227..58069755)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58570607..58581123)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 1 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 1 pseudogene 2 Neighboring gene HNRNPDL pseudogene 4 Neighboring gene RNA, 7SL, cytoplasmic 526, pseudogene Neighboring gene zinc finger and SCAN domain containing 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 135
Names
zinc finger protein 135 (clone pHZ-17)
zinc finger protein 61
zinc finger protein 78-like 1 (pT3)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164527.1NP_001157999.1  zinc finger protein 135 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region, compared to variant 1. It encodes isoform 3 which has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK094202, CN367970, DA232862, DB117846
    UniProtKB/TrEMBL
    Q8N9M3
    Conserved Domains (2) summary
    smart00349
    Location:2685
    KRAB; krueppel associated box
    pfam01352
    Location:2665
    KRAB; KRAB box
  2. NM_001164529.1NP_001158001.1  zinc finger protein 135 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 4 which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK094202, AK098011, AL833637, BX647775, DB117846, DB304820
    UniProtKB/Swiss-Prot
    P52742
    UniProtKB/TrEMBL
    Q8N9M3
    Conserved Domains (2) summary
    smart00349
    Location:2685
    KRAB; krueppel associated box
    pfam01352
    Location:2665
    KRAB; KRAB box
  3. NM_001164530.1NP_001158002.1  zinc finger protein 135 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two alternate segments in the coding region, one of which results in a frameshift, compared to variant 1. The encoded isoform 5 is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK094202, AK098011, AK297226, BX647775, DB304820
    Consensus CDS
    CCDS54330.1
    UniProtKB/Swiss-Prot
    P52742
    UniProtKB/TrEMBL
    B4DLZ7, Q8N9M3
    Related
    ENSP00000369437.4, ENST00000359978.10
    Conserved Domains (6) summary
    smart00349
    Location:2685
    KRAB; krueppel associated box
    COG5048
    Location:148389
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:228248
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:226248
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2665
    KRAB; KRAB box
    pfam13465
    Location:352377
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001289401.2NP_001276330.1  zinc finger protein 135 isoform 6

    See identical proteins and their annotated locations for NP_001276330.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 3' coding region, and includes an alternate exon that results in a distinct 5' UTR and uses of an alternate start codon, compared to variant 1. The encoded isoform (6) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK094202, AL833637, BC046434, BM993886, BX647775
    Consensus CDS
    CCDS74471.1
    UniProtKB/Swiss-Prot
    P52742
    UniProtKB/TrEMBL
    Q8N9M3
    Related
    ENSP00000321406.5, ENST00000313434.10
    Conserved Domains (6) summary
    smart00349
    Location:1473
    KRAB; krueppel associated box
    COG5048
    Location:240641
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:440460
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:214236
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:480505
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001289402.2NP_001276331.1  zinc finger protein 135 isoform 7

    See identical proteins and their annotated locations for NP_001276331.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate in-frame splice site in the 3' coding region, and includes an alternate exon that results in a distinct 5' UTR and uses of a downstream start codon, compared to variant 1. The encoded isoform (7) is shorter, compared to isoform 1.
    Source sequence(s)
    AK094202, AL833637, BC046434, BM993886, BX647775
    Consensus CDS
    CCDS74472.1
    UniProtKB/Swiss-Prot
    P52742
    UniProtKB/TrEMBL
    Q8N9M3
    Related
    ENSP00000427691.1, ENST00000506786.1
    Conserved Domains (3) summary
    COG5048
    Location:198599
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:398418
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:438463
    zf-H2C2_2; Zinc-finger double domain
  6. NM_003436.4NP_003427.3  zinc finger protein 135 isoform 2

    See identical proteins and their annotated locations for NP_003427.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon that results in a distinct 5' UTR and causes translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK094202, AK098011, AK295110, BX647775, DB304820
    Consensus CDS
    CCDS12970.2
    UniProtKB/Swiss-Prot
    P52742
    UniProtKB/TrEMBL
    Q8N9M3
    Related
    ENSP00000422074.1, ENST00000511556.5
    Conserved Domains (6) summary
    smart00349
    Location:1473
    KRAB; krueppel associated box
    COG5048
    Location:252653
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:226248
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:492517
    zf-H2C2_2; Zinc-finger double domain
  7. NM_007134.1NP_009065.1  zinc finger protein 135 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK094202, AK098011, BX647775, DB117846, DB304820
    Consensus CDS
    CCDS54329.1
    UniProtKB/Swiss-Prot
    P52742
    UniProtKB/TrEMBL
    Q8N9M3
    Related
    ENSP00000441410.1, ENST00000401053.8
    Conserved Domains (6) summary
    smart00349
    Location:2685
    KRAB; krueppel associated box
    COG5048
    Location:264665
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:464484
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:238260
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2665
    KRAB; KRAB box
    pfam13465
    Location:504529
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    58059227..58069755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027242.1XP_016882731.1  zinc finger protein 135 isoform X5

  2. XM_006723362.4XP_006723425.1  zinc finger protein 135 isoform X1

    See identical proteins and their annotated locations for XP_006723425.1

    UniProtKB/Swiss-Prot
    P52742
    Conserved Domains (6) summary
    smart00349
    Location:1473
    KRAB; krueppel associated box
    COG5048
    Location:252653
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:226248
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:492517
    zf-H2C2_2; Zinc-finger double domain
  3. XM_005259211.1XP_005259268.1  zinc finger protein 135 isoform X2

    Conserved Domains (6) summary
    smart00349
    Location:2685
    KRAB; krueppel associated box
    COG5048
    Location:252653
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:226248
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2665
    KRAB; KRAB box
    pfam13465
    Location:492517
    zf-H2C2_2; Zinc-finger double domain
  4. XM_017027241.1XP_016882730.1  zinc finger protein 135 isoform X4

    Conserved Domains (3) summary
    COG5048
    Location:210611
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:410430
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:450475
    zf-H2C2_2; Zinc-finger double domain
  5. XM_006723363.3XP_006723426.1  zinc finger protein 135 isoform X1

    See identical proteins and their annotated locations for XP_006723426.1

    UniProtKB/Swiss-Prot
    P52742
    Conserved Domains (6) summary
    smart00349
    Location:1473
    KRAB; krueppel associated box
    COG5048
    Location:252653
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:226248
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:492517
    zf-H2C2_2; Zinc-finger double domain
  6. XM_017027240.1XP_016882729.1  zinc finger protein 135 isoform X3

    UniProtKB/Swiss-Prot
    P52742
    Conserved Domains (6) summary
    smart00349
    Location:1473
    KRAB; krueppel associated box
    COG5048
    Location:240641
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:440460
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:214236
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:480505
    zf-H2C2_2; Zinc-finger double domain
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