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Lrg1 leucine-rich alpha-2-glycoprotein 1 [ Mus musculus (house mouse) ]

Gene ID: 76905, updated on 13-Dec-2022

Summary

Official Symbol
Lrg1provided by MGI
Official Full Name
leucine-rich alpha-2-glycoprotein 1provided by MGI
Primary source
MGI:MGI:1924155
See related
Ensembl:ENSMUSG00000037095 AllianceGenome:MGI:1924155
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lrg; Lrhg; 1300008B03Rik; 2310031E04Rik
Summary
Enables transforming growth factor beta receptor binding activity. Acts upstream of or within several processes, including brown fat cell differentiation; positive regulation of endothelial cell proliferation; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in extracellular space. Is expressed in pancreas mesenchyme. Orthologous to human LRG1 (leucine rich alpha-2-glycoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 229.9), mammary gland adult (RPKM 136.7) and 10 other tissues See more
Orthologs
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Genomic context

See Lrg1 in Genome Data Viewer
Location:
17 29.17 cM; 17 D
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56426678..56428946, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56119678..56121946, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene HDGF like 2 Neighboring gene perilipin 4 Neighboring gene perilipin 5 Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B Neighboring gene tumor necrosis factor, alpha-induced protein 8-like 1 Neighboring gene myeloid derived growth factor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

General gene information

Markers

Homology

Clone Names

  • MGC102387

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables potassium channel activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transforming growth factor beta receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables type I transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables type II transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within brown fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of keratinocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of keratinocyte migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of leukocyte adhesion to vascular endothelial cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of leukocyte adhesion to vascular endothelial cell ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of epithelial cell proliferation involved in wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of epithelial cell proliferation involved in wound healing ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within wound healing, spreading of epidermal cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within wound healing, spreading of epidermal cells ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
leucine-rich alpha-2-glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029796.2NP_084072.1  leucine-rich alpha-2-glycoprotein precursor

    See identical proteins and their annotated locations for NP_084072.1

    Status: PROVISIONAL

    Source sequence(s)
    BC030733
    Consensus CDS
    CCDS28895.1
    UniProtKB/TrEMBL
    Q91XL1
    Related
    ENSMUSP00000038048.8, ENSMUST00000041357.9
    Conserved Domains (4) summary
    smart00082
    Location:292338
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:74294
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:6586
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:109169
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    56426678..56428946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)