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Jade2 jade family PHD finger 2 [ Mus musculus (house mouse) ]

Gene ID: 76901, updated on 30-Apr-2024

Summary

Official Symbol
Jade2provided by MGI
Official Full Name
jade family PHD finger 2provided by MGI
Primary source
MGI:MGI:1924151
See related
Ensembl:ENSMUSG00000020387 AllianceGenome:MGI:1924151
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Phf15; mKIAA0239; 1200017K05Rik
Summary
Enables ubiquitin protein ligase activity. Acts upstream of or within SMAD protein signal transduction; generation of neurons; and protein ubiquitination. Predicted to be located in nucleoplasm. Predicted to be part of histone acetyltransferase complex. Is expressed in bladder; male associated reproductive structure; testis; ureter; and urethra of male. Orthologous to human JADE2 (jade family PHD finger 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 14.2), lung adult (RPKM 11.2) and 20 other tissues See more
Orthologs
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Genomic context

See Jade2 in Genome Data Viewer
Location:
11 B1.3; 11 31.5 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51704278..51749835, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (51813448..51859011, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene SEC24 homolog A, COPII coat complex component Neighboring gene predicted gene, 25291 Neighboring gene secretion associated Ras related GTPase 1B Neighboring gene STARR-positive B cell enhancer ABC_E10673 Neighboring gene STARR-positive B cell enhancer mm9_chr11:51671514-51671815 Neighboring gene predicted gene, 30110 Neighboring gene predicted gene, 39820 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:51697260-51697496 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:51697614-51697723 Neighboring gene predicted gene, 39821

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to histone H3K14 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone H4K12 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone H4K5 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone H4K8 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase Jade-2
Names
PHD finger protein 15
jade family PHD finger protein 2
protein Jade-2
NP_001344517.1
NP_955003.2
XP_006534531.1
XP_006534532.1
XP_006534533.1
XP_011247611.1
XP_036012980.1
XP_036012981.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357588.3NP_001344517.1  E3 ubiquitin-protein ligase Jade-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645602, AL669920
    Conserved Domains (3) summary
    cd15705
    Location:326436
    ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins
    cl26464
    Location:676852
    Atrophin-1; Atrophin-1 family
    cl26518
    Location:209578
    EPL1; Enhancer of polycomb-like
  2. NM_199299.5NP_955003.2  E3 ubiquitin-protein ligase Jade-2 isoform 2

    See identical proteins and their annotated locations for NP_955003.2

    Status: VALIDATED

    Source sequence(s)
    AL645602, AL669920
    Consensus CDS
    CCDS24662.1
    UniProtKB/Swiss-Prot
    Q3UHD5, Q6IE83, Q6ZQF7
    Related
    ENSMUSP00000020655.8, ENSMUST00000020655.14
    Conserved Domains (3) summary
    PHA03247
    Location:604780
    PHA03247; large tegument protein UL36; Provisional
    COG5141
    Location:137506
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15705
    Location:254364
    ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    51704278..51749835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534470.5XP_006534533.1  E3 ubiquitin-protein ligase Jade-2 isoform X2

    See identical proteins and their annotated locations for XP_006534533.1

    UniProtKB/Swiss-Prot
    Q3UHD5, Q6IE83, Q6ZQF7
    Conserved Domains (3) summary
    PHA03247
    Location:604780
    PHA03247; large tegument protein UL36; Provisional
    COG5141
    Location:137506
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15705
    Location:254364
    ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins
  2. XM_011249309.3XP_011247611.1  E3 ubiquitin-protein ligase Jade-2 isoform X2

    See identical proteins and their annotated locations for XP_011247611.1

    UniProtKB/Swiss-Prot
    Q3UHD5, Q6IE83, Q6ZQF7
    Conserved Domains (3) summary
    PHA03247
    Location:604780
    PHA03247; large tegument protein UL36; Provisional
    COG5141
    Location:137506
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15705
    Location:254364
    ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins
  3. XM_036157088.1XP_036012981.1  E3 ubiquitin-protein ligase Jade-2 isoform X2

    UniProtKB/Swiss-Prot
    Q3UHD5, Q6IE83, Q6ZQF7
    Conserved Domains (3) summary
    PHA03247
    Location:604780
    PHA03247; large tegument protein UL36; Provisional
    COG5141
    Location:137506
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15705
    Location:254364
    ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins
  4. XM_006534469.5XP_006534532.1  E3 ubiquitin-protein ligase Jade-2 isoform X2

    See identical proteins and their annotated locations for XP_006534532.1

    UniProtKB/Swiss-Prot
    Q3UHD5, Q6IE83, Q6ZQF7
    Conserved Domains (3) summary
    PHA03247
    Location:604780
    PHA03247; large tegument protein UL36; Provisional
    COG5141
    Location:137506
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15705
    Location:254364
    ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins
  5. XM_006534468.5XP_006534531.1  E3 ubiquitin-protein ligase Jade-2 isoform X1

    Conserved Domains (3) summary
    PHA03247
    Location:640816
    PHA03247; large tegument protein UL36; Provisional
    COG5141
    Location:173542
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15705
    Location:290400
    ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins
  6. XM_036157087.1XP_036012980.1  E3 ubiquitin-protein ligase Jade-2 isoform X2

    UniProtKB/Swiss-Prot
    Q3UHD5, Q6IE83, Q6ZQF7
    Conserved Domains (3) summary
    PHA03247
    Location:604780
    PHA03247; large tegument protein UL36; Provisional
    COG5141
    Location:137506
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15705
    Location:254364
    ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins