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Jade2 jade family PHD finger 2 [ Mus musculus (house mouse) ]

Gene ID: 76901, updated on 5-Jan-2023

Summary

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Official Symbol
Jade2provided by MGI
Official Full Name
jade family PHD finger 2provided by MGI
Primary source
MGI:MGI:1924151
See related
Ensembl:ENSMUSG00000020387 AllianceGenome:MGI:1924151
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Phf15; mKIAA0239; 1200017K05Rik
Summary
Enables ubiquitin protein ligase activity. Acts upstream of or within SMAD protein signal transduction; generation of neurons; and protein ubiquitination. Predicted to be located in nucleoplasm. Predicted to be part of histone acetyltransferase complex. Is expressed in bladder; male associated reproductive structure; testis; ureter; and urethra of male. Orthologous to human JADE2 (jade family PHD finger 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 14.2), lung adult (RPKM 11.2) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Jade2 in Genome Data Viewer
Location:
11; 11 B1.3
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51704275..51749835, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (51813448..51859011, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Sec24 related gene family, member A (S. cerevisiae) Neighboring gene predicted gene, 25291 Neighboring gene secretion associated Ras related GTPase 1B Neighboring gene predicted gene, 30110 Neighboring gene predicted gene, 39820 Neighboring gene predicted gene, 39821

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. JADE2 Is Essential for Hippocampal Synaptic Plasticity and Cognitive Functions in Mice. Fan M, et al. Biol Psychiatry, 2022 Nov 15. PMID 36008159
  2. Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development. Tzouanacou E, et al. Mol Cell Biol, 2003 Dec. PMID 14612400, Free PMC Article
  3. Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking system in neural development. Han X, et al. Mol Cell, 2014 Aug 7. PMID 25018020
  4. USP10 deubiquitinates Tau, mediating its aggregation. Wei Z, et al. Cell Death Dis, 2022 Aug 20. PMID 35987808, Free PMC Article
  5. TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos. Redshaw N, et al. PLoS One, 2013. PMID 23390484, Free PMC Article

See all (26) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. JADE2 Is Essential for Hippocampal Synaptic Plasticity and Cognitive Functions in Mice.
    Title: JADE2 Is Essential for Hippocampal Synaptic Plasticity and Cognitive Functions in Mice.
  2. Results show that Jade-2 is a major LSD1 negative regulator during neurogenesis in vitro and in vivo in both mouse developing cerebral cortices and zebra fish embryos.
    Title: Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking system in neural development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to histone H3K14 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4K12 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4K5 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4K8 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in histone H4-K12 acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in histone H4-K5 acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in histone H4-K8 acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in histone modification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron projection extension IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of neurogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein autoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein polyubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of neurogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
part_of histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase Jade-2
Names
PHD finger protein 15
jade family PHD finger protein 2
protein Jade-2
NP_001344517.1
NP_955003.2
XP_006534531.1
XP_006534532.1
XP_006534533.1
XP_011247611.1
XP_036012980.1
XP_036012981.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357588.3 → NP_001344517.1  E3 ubiquitin-protein ligase Jade-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645602, AL669920
    Conserved Domains (3) summary
    cd15705
    Location:326 → 436
    ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins
    cl26464
    Location:676 → 852
    Atrophin-1; Atrophin-1 family
    cl26518
    Location:209 → 578
    EPL1; Enhancer of polycomb-like

  2. NM_199299.5 → NP_955003.2  E3 ubiquitin-protein ligase Jade-2 isoform 2

    See identical proteins and their annotated locations for NP_955003.2

    Status: VALIDATED

    Source sequence(s)
    AL645602, AL669920
    Consensus CDS
    CCDS24662.1
    UniProtKB/Swiss-Prot
    Q6IE83, Q6ZQF7
    Related
    ENSMUSP00000020655.8, ENSMUST00000020655.14
    Conserved Domains (3) summary
    PHA03247
    Location:604 → 780
    PHA03247; large tegument protein UL36; Provisional
    COG5141
    Location:137 → 506
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15705
    Location:254 → 364
    ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    51704275..51749835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534470.5 → XP_006534533.1  E3 ubiquitin-protein ligase Jade-2 isoform X2

    See identical proteins and their annotated locations for XP_006534533.1

    UniProtKB/Swiss-Prot
    Q6IE83, Q6ZQF7
    Conserved Domains (3) summary
    PHA03247
    Location:604 → 780
    PHA03247; large tegument protein UL36; Provisional
    COG5141
    Location:137 → 506
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15705
    Location:254 → 364
    ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins

  2. XM_011249309.3 → XP_011247611.1  E3 ubiquitin-protein ligase Jade-2 isoform X2

    See identical proteins and their annotated locations for XP_011247611.1

    UniProtKB/Swiss-Prot
    Q6IE83, Q6ZQF7
    Conserved Domains (3) summary
    PHA03247
    Location:604 → 780
    PHA03247; large tegument protein UL36; Provisional
    COG5141
    Location:137 → 506
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15705
    Location:254 → 364
    ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins

  3. XM_036157088.1 → XP_036012981.1  E3 ubiquitin-protein ligase Jade-2 isoform X2

    UniProtKB/Swiss-Prot
    Q6IE83
    Conserved Domains (3) summary
    PHA03247
    Location:604 → 780
    PHA03247; large tegument protein UL36; Provisional
    COG5141
    Location:137 → 506
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15705
    Location:254 → 364
    ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins

  4. XM_006534469.5 → XP_006534532.1  E3 ubiquitin-protein ligase Jade-2 isoform X2

    See identical proteins and their annotated locations for XP_006534532.1

    UniProtKB/Swiss-Prot
    Q6IE83, Q6ZQF7
    Conserved Domains (3) summary
    PHA03247
    Location:604 → 780
    PHA03247; large tegument protein UL36; Provisional
    COG5141
    Location:137 → 506
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15705
    Location:254 → 364
    ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins

  5. XM_006534468.5 → XP_006534531.1  E3 ubiquitin-protein ligase Jade-2 isoform X1

    Conserved Domains (3) summary
    PHA03247
    Location:640 → 816
    PHA03247; large tegument protein UL36; Provisional
    COG5141
    Location:173 → 542
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15705
    Location:290 → 400
    ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins

  6. XM_036157087.1 → XP_036012980.1  E3 ubiquitin-protein ligase Jade-2 isoform X2

    UniProtKB/Swiss-Prot
    Q6IE83
    Conserved Domains (3) summary
    PHA03247
    Location:604 → 780
    PHA03247; large tegument protein UL36; Provisional
    COG5141
    Location:137 → 506
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15705
    Location:254 → 364
    ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZQF7.2 GenPept UniProtKB/Swiss-Prot:Q6ZQF7

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