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B3gat1 beta-1,3-glucuronyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 76898, updated on 5-Mar-2024

Summary

Official Symbol
B3gat1provided by MGI
Official Full Name
beta-1,3-glucuronyltransferase 1provided by MGI
Primary source
MGI:MGI:1924148
See related
Ensembl:ENSMUSG00000045994 AllianceGenome:MGI:1924148
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hnk1; Glcatp; GlcAT-P; 0710007K08Rik
Summary
Enables UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. Predicted to be involved in carbohydrate metabolic process and chondroitin sulfate proteoglycan biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in Golgi membrane. Is expressed in several structures, including nervous system and neural retina. Orthologous to human B3GAT1 (beta-1,3-glucuronyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 70.4), whole brain E14.5 (RPKM 54.3) and 5 other tissues See more
Orthologs
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Genomic context

Location:
9 A4; 9 11.49 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (26644813..26672646)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (26733723..26761350)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene squamous cell carcinoma antigen recognized by T-cells 3 pseudogene Neighboring gene predicted gene, 30313 Neighboring gene STARR-seq mESC enhancer starr_23611 Neighboring gene STARR-seq mESC enhancer starr_23613 Neighboring gene galactosidase, beta 1-like 2 Neighboring gene galactosidase, beta 1 like 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Clone Names

  • KIAA4235

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chondroitin sulfate proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glycosaminoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1
Names
UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase
glcUAT-P
glucuronosyltransferase P
NP_001297695.1
NP_084068.1
XP_006510737.1
XP_030100573.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310766.1NP_001297695.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_001297695.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK044599, AK082739, BC034655, BY626420
    Consensus CDS
    CCDS80970.1
    UniProtKB/TrEMBL
    Q5DTF9
    Related
    ENSMUSP00000124067.2, ENSMUST00000160899.8
    Conserved Domains (1) summary
    cd00218
    Location:97329
    GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis
  2. NM_029792.1NP_084068.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 isoform 2

    See identical proteins and their annotated locations for NP_084068.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    BC034655
    Consensus CDS
    CCDS22936.1
    UniProtKB/Swiss-Prot
    Q6PIG8, Q8BXN8, Q8R531, Q9CW73
    UniProtKB/TrEMBL
    Q5DTF9
    Related
    ENSMUSP00000125700.2, ENSMUST00000161115.8
    Conserved Domains (1) summary
    pfam03360
    Location:105315
    Glyco_transf_43; Glycosyltransferase family 43

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    26644813..26672646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510674.3XP_006510737.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006510737.1

    UniProtKB/Swiss-Prot
    Q6PIG8, Q8BXN8, Q8R531, Q9CW73
    UniProtKB/TrEMBL
    Q5DTF9
    Related
    ENSMUSP00000124752.3, ENSMUST00000161431.3
    Conserved Domains (1) summary
    pfam03360
    Location:105315
    Glyco_transf_43; Glycosyltransferase family 43
  2. XM_030244713.1XP_030100573.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 isoform X2

    UniProtKB/TrEMBL
    Q8BLT8, Q8R1V2
    Conserved Domains (1) summary
    cd00218
    Location:27259
    GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis