U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Bicd2 BICD cargo adaptor 2 [ Mus musculus (house mouse) ]

Gene ID: 76895, updated on 8-May-2024

Summary

Official Symbol
Bicd2provided by MGI
Official Full Name
BICD cargo adaptor 2provided by MGI
Primary source
MGI:MGI:1924145
See related
Ensembl:ENSMUSG00000037933 AllianceGenome:MGI:1924145
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables several functions, including dynactin binding activity; dynein complex binding activity; and dynein light intermediate chain binding activity. Involved in several processes, including microtubule anchoring at microtubule organizing center; minus-end-directed organelle transport along microtubule; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Acts upstream of or within microtubule-based movement. Located in Golgi apparatus and cytoplasmic vesicle. Is expressed in several structures, including central nervous system; dorsal root ganglion; olfactory epithelium; and retina. Human ortholog(s) of this gene implicated in spinal muscular atrophy with lower extremity predominance 2A and spinal muscular atrophy with lower extremity predominante 2B. Orthologous to human BICD2 (BICD cargo adaptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 19.5), testis adult (RPKM 16.2) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Bicd2 in Genome Data Viewer
Location:
13 A5; 13 25.22 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (49495025..49540502)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (49341549..49387026)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8525 Neighboring gene STARR-positive B cell enhancer ABC_E8526 Neighboring gene STARR-positive B cell enhancer mm9_chr13:49346365-49346665 Neighboring gene RIKEN cDNA E030007A22 gene Neighboring gene predicted gene, 52024 Neighboring gene sushi domain containing 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:49363145-49363298 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:49402581-49402764 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:49402849-49403036 Neighboring gene FYVE, RhoGEF and PH domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E4067 Neighboring gene STARR-seq mESC enhancer starr_34478 Neighboring gene inositol 1,3,4,5,6-pentakisphosphate 2-kinase Neighboring gene centromere protein P Neighboring gene testis derived transcript 3, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0699, 0610027D24Rik, 1110005D12Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytoskeletal anchor activity IEA
Inferred from Electronic Annotation
more info
 
enables dynactin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dynactin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables dynein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dynein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dynein light intermediate chain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in centrosome localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule anchoring at microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule anchoring at microtubule organizing center IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within microtubule-based movement IDA
Inferred from Direct Assay
more info
PubMed 
involved_in minus-end-directed organelle transport along microtubule IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to Golgi apparatus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in annulate lamellae ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein bicaudal D homolog 2
Names
bic-D 2
bicaudal D homolog 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039179.2NP_001034268.1  protein bicaudal D homolog 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK122348, BP775855, CF538535
    Consensus CDS
    CCDS36657.1
    UniProtKB/TrEMBL
    Q3TBD4
    Related
    ENSMUSP00000039394.7, ENSMUST00000048544.14
    Conserved Domains (3) summary
    pfam09730
    Location:83797
    BicD; Microtubule-associated protein Bicaudal-D
    cl19219
    Location:55169
    DUF342; Protein of unknown function (DUF342)
    cl19252
    Location:178230
    MreC; rod shape-determining protein MreC
  2. NM_001039180.2NP_001034269.1  protein bicaudal D homolog 2 isoform 3

    See identical proteins and their annotated locations for NP_001034269.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in both UTRs and the 3' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform is shorter, compared to isoform 1.
    Source sequence(s)
    AK122348, BP775855, CF538535
    Consensus CDS
    CCDS49261.1
    UniProtKB/TrEMBL
    D3Z390, Q3TBD4
    Related
    ENSMUSP00000105711.3, ENSMUST00000110084.4
    Conserved Domains (2) summary
    pfam09730
    Location:9723
    BicD; Microtubule-associated protein Bicaudal-D
    cl19252
    Location:104156
    MreC; rod shape-determining protein MreC
  3. NM_029791.4NP_084067.1  protein bicaudal D homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_084067.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding sequence and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK122348, BP775855, CF538535
    Consensus CDS
    CCDS36656.1
    UniProtKB/Swiss-Prot
    Q80TU1, Q8BTE3, Q921C5, Q9DCL3
    UniProtKB/TrEMBL
    Q3TBD4
    Related
    ENSMUSP00000105712.4, ENSMUST00000110085.11
    Conserved Domains (3) summary
    pfam09730
    Location:83797
    BicD; Microtubule-associated protein Bicaudal-D
    cl19219
    Location:55169
    DUF342; Protein of unknown function (DUF342)
    cl19252
    Location:178230
    MreC; rod shape-determining protein MreC

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    49495025..49540502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244429.4XP_011242731.1  protein bicaudal D homolog 2 isoform X1

    Conserved Domains (1) summary
    pfam09730
    Location:23618
    BicD; Microtubule-associated protein Bicaudal-D