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Rnft1 ring finger protein, transmembrane 1 [ Mus musculus (house mouse) ]

Gene ID: 76892, updated on 30-Apr-2024

Summary

Official Symbol
Rnft1provided by MGI
Official Full Name
ring finger protein, transmembrane 1provided by MGI
Primary source
MGI:MGI:1924142
See related
Ensembl:ENSMUSG00000020521 AllianceGenome:MGI:1924142
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610013E23Rik
Summary
Predicted to enable ubiquitin binding activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of ERAD pathway and protein autoubiquitination. Predicted to be located in endosome and membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human RNFT1 (ring finger protein, transmembrane 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 6.6), limb E14.5 (RPKM 4.7) and 24 other tissues See more
Orthologs
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Genomic context

See Rnft1 in Genome Data Viewer
Location:
11 C; 11 51.82 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (86375483..86389833)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (86484657..86499007)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 185 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5258 Neighboring gene predicted gene, 26439 Neighboring gene STARR-positive B cell enhancer ABC_E5259 Neighboring gene STARR-positive B cell enhancer ABC_E3003 Neighboring gene STARR-seq mESC enhancer starr_30268 Neighboring gene STARR-seq mESC enhancer starr_30269 Neighboring gene ribosomal protein S6 kinase, polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_30270 Neighboring gene STARR-positive B cell enhancer ABC_E3004 Neighboring gene tubulin, delta 1 Neighboring gene predicted gene 9975

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in positive regulation of ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of ERAD pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNFT1
Names
RING finger and transmembrane domain-containing protein 1
NP_084064.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029788.5NP_084064.1  E3 ubiquitin-protein ligase RNFT1

    See identical proteins and their annotated locations for NP_084064.1

    Status: PROVISIONAL

    Source sequence(s)
    AL604063
    Consensus CDS
    CCDS25200.1
    UniProtKB/Swiss-Prot
    Q3U649, Q80X62, Q9DCN7
    Related
    ENSMUSP00000020827.7, ENSMUST00000020827.7
    Conserved Domains (1) summary
    cd00162
    Location:335376
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    86375483..86389833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)