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Gper1 G protein-coupled estrogen receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 76854, updated on 31-Jan-2019

Summary

Official Symbol
Gper1provided by MGI
Official Full Name
G protein-coupled estrogen receptor 1provided by MGI
Primary source
MGI:MGI:1924104
See related
Ensembl:ENSMUSG00000053647
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gper; Ceprl; FEG-1; Gpr30; CMKRL2; GPCR-Br; 6330420K13Rik
Expression
Broad expression in stomach adult (RPKM 12.7), genital fat pad adult (RPKM 4.2) and 17 other tissues See more
Orthologs

Genomic context

See Gper1 in Genome Data Viewer
Location:
5; 5 G2
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (139422969..139427800)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (139899133..139903754)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3110082I17 gene Neighboring gene G protein-coupled receptor 146 Neighboring gene G protein-coupled receptor 146 Neighboring gene RIKEN cDNA C130050O18 gene Neighboring gene zinc finger, AN1-type domain 2A Neighboring gene RIKEN cDNA 4930500L23 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
 
estrogen receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
estrogen receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
estrogen receptor activity ISO
Inferred from Sequence Orthology
more info
 
hormone binding ISO
Inferred from Sequence Orthology
more info
 
steroid binding ISO
Inferred from Sequence Orthology
more info
 
steroid hormone binding ISO
Inferred from Sequence Orthology
more info
 
steroid hormone receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
apoptotic chromosome condensation ISO
Inferred from Sequence Orthology
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to estradiol stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to estradiol stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to estradiol stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to mineralocorticoid stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to peptide hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
intracellular steroid hormone receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular steroid hormone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of DNA metabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell cycle process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of leukocyte activation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of lipid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vascular smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
nuclear fragmentation involved in apoptotic nuclear change ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood vessel diameter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac vascular smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of inositol trisphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neurogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of uterine smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
steroid hormone mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
axon ISO
Inferred from Sequence Orthology
more info
 
axon terminus ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
dendritic spine head ISO
Inferred from Sequence Orthology
more info
 
dendritic spine membrane ISO
Inferred from Sequence Orthology
more info
 
early endosome ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
hippocampal mossy fiber to CA3 synapse IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
keratin filament ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
presynaptic active zone ISO
Inferred from Sequence Orthology
more info
 
presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
recycling endosome ISO
Inferred from Sequence Orthology
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
G-protein coupled estrogen receptor 1
Names
G-protein coupled receptor 30
chemoattractant receptor-like 2
constitutively expressed peptide-like receptor like
mER
membrane estrogen receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029771.3NP_084047.2  G-protein coupled estrogen receptor 1

    See identical proteins and their annotated locations for NP_084047.2

    Status: VALIDATED

    Source sequence(s)
    AK030375, BC138616, CX204119
    Consensus CDS
    CCDS19811.1
    UniProtKB/Swiss-Prot
    Q8BMP4
    Related
    ENSMUSP00000080370.3, ENSMUST00000066211.4
    Conserved Domains (1) summary
    cd14989
    Location:60335
    7tmA_GPER1; G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    139422969..139427800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504757.3XP_006504820.1  G-protein coupled estrogen receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006504820.1

    UniProtKB/Swiss-Prot
    Q8BMP4
    Conserved Domains (1) summary
    cd14989
    Location:60335
    7tmA_GPER1; G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
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