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Dtl denticleless E3 ubiquitin protein ligase [ Mus musculus (house mouse) ]

Gene ID: 76843, updated on 26-Sep-2022

Summary

Official Symbol
Dtlprovided by MGI
Official Full Name
denticleless E3 ubiquitin protein ligaseprovided by MGI
Primary source
MGI:MGI:1924093
See related
Ensembl:ENSMUSG00000037474 AllianceGenome:MGI:1924093
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ramp; L2dtl; 2810047L02Rik; 5730564G15Rik
Summary
Predicted to enable protein-macromolecule adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including protein ubiquitination; regulation of G2/M transition of mitotic cell cycle; and translesion synthesis. Predicted to act upstream of or within DNA replication and rhythmic process. Predicted to be located in centrosome; cytosol; and nuclear lumen. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex and Cul4B-RING E3 ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in several structures, including brain ventricular layer; genitourinary system; hemolymphoid system gland; lung; and medulla oblongata part of 4th ventricle choroid plexus. Orthologous to human DTL (denticleless E3 ubiquitin protein ligase homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 10.9), CNS E11.5 (RPKM 9.6) and 15 other tissues See more
Orthologs
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Genomic context

See Dtl in Genome Data Viewer
Location:
1; 1 H6
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (191269468..191307656, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (191537356..191575544, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32200 Neighboring gene predicted gene, 32334 Neighboring gene integrator complex subunit 7 Neighboring gene predicted gene, 39741 Neighboring gene lysophosphatidylglycerol acyltransferase 1 Neighboring gene predicted gene, 22446

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
part_of Cul4A-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
part_of Cul4B-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
denticleless protein homolog
Names
Meth A ramp
Sarcoma antigen S35
denticleless homolog
lethal(2) denticleless protein homolog
meth A retinoic acid-regulated nuclear matrix-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305233.1NP_001292162.1  denticleless protein homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, initiates translation at an alternate start codon, and uses an alternate exon in the 5' coding region compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC132830, AK054412, AK133177, BB841951
    UniProtKB/Swiss-Prot
    Q3TLR7
    Conserved Domains (3) summary
    COG2319
    Location:22285
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:2260
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:22265
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_029766.3NP_084042.1  denticleless protein homolog isoform 1

    See identical proteins and their annotated locations for NP_084042.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC132830, AK054412, AK133177, BB841951, CF898098
    Consensus CDS
    CCDS15621.1
    UniProtKB/Swiss-Prot
    Q3TLR7, Q9CZ76
    Related
    ENSMUSP00000027933.6, ENSMUST00000027933.11
    Conserved Domains (2) summary
    sd00039
    Location:5396
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:65389
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    191269468..191307656 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238925.2XP_011237227.1  denticleless protein homolog isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:55101
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:51224
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...