Dtl denticleless E3 ubiquitin protein ligase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dtlprovided by MGI
Official Full Name: denticleless E3 ubiquitin protein ligaseprovided by MGI
Primary source: MGI:MGI:1924093
See related: Ensembl:ENSMUSG00000037474 AllianceGenome:MGI:1924093
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ramp; L2dtl; 2810047L02Rik; 5730564G15Rik
Summary: Predicted to enable protein-macromolecule adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including protein ubiquitination; regulation of G2/M transition of mitotic cell cycle; and translesion synthesis. Predicted to be located in centrosome; cytosol; and nuclear lumen. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex and Cul4B-RING E3 ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in several structures, including brain ventricular layer; early conceptus; genitourinary system; hemolymphoid system gland; and lung. Orthologous to human DTL (denticleless E3 ubiquitin protein ligase homolog). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Broad expression in liver E14 (RPKM 10.9), CNS E11.5 (RPKM 9.6) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H6; 1 96.44 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (191269468..191307656, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (191537356..191575544, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RUVBL1 ubiquitination by DTL promotes RUVBL1/2-beta-catenin-mediated transcriptional regulation of NHEJ pathway and enhances radiation resistance in breast cancer.
Title: RUVBL1 ubiquitination by DTL promotes RUVBL1/2-β-catenin-mediated transcriptional regulation of NHEJ pathway and enhances radiation resistance in breast cancer.
Mice lacking DCAF2 in placenta die at the gastrulation stage.
Title: Mice lacking DCAF2 in placenta die at the gastrulation stage.
this study shows that CRL4(DCAF2) is required for mature T-cell expansion via Aurora B-regulated proteasome activity
Title: CRL4(DCAF2) is required for mature T-cell expansion via Aurora B-regulated proteasome activity.
This study shows that CRL4(DCAF2) is crucial for controlling NIK stability and highlights a unique mechanism that controls inflammatory diseases.
Title: CRL4(DCAF2) negatively regulates IL-23 production in dendritic cells and limits the development of psoriasis.
Maternal DCAF2 protein is crucial for prevention of DNA re-replication in the first and unique mitotic cell cycle of the zygote.
Title: Maternal DCAF2 is crucial for maintenance of genome stability during the first cell cycle in mice.
while interaction with PCNA was important for targeting p21 to the CRL4Cdt2 ligase re-localized to MVM replication centers
Title: Efficient parvovirus replication requires CRL4Cdt2-targeted depletion of p21 to prevent its inhibitory interaction with PCNA.
L2dtl gene expression is essential for very early mouse embryonic development
Title: L2dtl is essential for cell survival and nuclear division in early mouse embryonic development.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048745 (e-PCR)
- UniSTS:145195

Dtl (e-PCR), detects polymorphism
- UniSTS:498735

RH136036 (e-PCR)
- UniSTS:210031

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
contributes_to ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
contributes_to ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in mitotic G2 DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic G2 DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in mitotic G2 DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2 DNA damage checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein monoubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein monoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein monoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein polyubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to UV	IEA Inferred from Electronic Annotation more info
involved_in response to UV	ISO Inferred from Sequence Orthology more info
involved_in response to UV	ISS Inferred from Sequence or Structural Similarity more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in translesion synthesis	IEA Inferred from Electronic Annotation more info
involved_in translesion synthesis	ISO Inferred from Sequence Orthology more info
involved_in translesion synthesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of Cul4-RING E3 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul4A-RING E3 ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of Cul4A-RING E3 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul4A-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of Cul4B-RING E3 ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of Cul4B-RING E3 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul4B-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: denticleless protein homolog

Names: Meth A ramp; Sarcoma antigen S35; denticleless homolog; lethal(2) denticleless protein homolog; meth A retinoic acid-regulated nuclear matrix-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305233.1 → NP_001292162.1 denticleless protein homolog isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, initiates translation at an alternate start codon, and uses an alternate exon in the 5' coding region compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC132830, AK054412, AK133177, BB841951

UniProtKB/Swiss-Prot

Q3TLR7

Conserved Domains (3) summary

COG2319
Location:22 → 285

WD40; WD40 repeat [General function prediction only]

sd00039
Location:22 → 60

7WD40; WD40 repeat [structural motif]

cl02567
Location:22 → 265

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_029766.3 → NP_084042.1 denticleless protein homolog isoform 1

See identical proteins and their annotated locations for NP_084042.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC132830, AK054412, AK133177, BB841951, CF898098

Consensus CDS

CCDS15621.1

UniProtKB/Swiss-Prot

Q3TLR7, Q3TTE9, Q6PAN1, Q80WY1, Q80WY2, Q8BW38, Q9CZ76

Related

ENSMUSP00000027933.6, ENSMUST00000027933.11

Conserved Domains (2) summary

sd00039
Location:53 → 96

7WD40; WD40 repeat [structural motif]

cl29593
Location:65 → 389

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

191269468..191307656 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011238925.2 → XP_011237227.1 denticleless protein homolog isoform X1

Conserved Domains (2) summary

sd00039
Location:55 → 101

7WD40; WD40 repeat [structural motif]

cl29593
Location:51 → 224

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...