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fas Fas cell surface death receptor [ Danio rerio (zebrafish) ]

Gene ID: 768248, updated on 14-Apr-2024

Summary

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Official Symbol
fasprovided by ZNC
Official Full Name
Fas cell surface death receptorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-061019-2
See related
Ensembl:ENSDARG00000043586 AllianceGenome:ZFIN:ZDB-GENE-061019-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable tumor necrosis factor-activated receptor activity. Acts upstream of or within notochord development and positive regulation of apoptotic process. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of CD95 death-inducing signaling complex. Predicted to be active in external side of plasma membrane and membrane raft. Is expressed in several structures, including blastoderm; eye; gut; notochord; and ovary. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 17
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (23619302..23631827, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (23599896..23611375, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene interferon-induced protein with tetratricopeptide repeats 15 Neighboring gene interferon-induced protein with tetratricopeptide repeats 14 Neighboring gene phosphatase and tensin homolog A Neighboring gene 3'-phosphoadenosine 5'-phosphosulfate synthase 2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Effects of short term lead exposure on gut microbiota and hepatic metabolism in adult zebrafish. Xia J, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2018 Jul. PMID 29574035
  2. FAS/FASL are dysregulated in chordoma and their loss-of-function impairs zebrafish notochord formation. Ferrari L, et al. Oncotarget, 2014 Jul 30. PMID 25071022, Free PMC Article
  3. Methylnitrosourea, dimethylbenzanthracene and benzoapyrene differentially affect redox pathways, apoptosis and immunity in zebrafish. Eğimezer G, et al. Hum Exp Toxicol, 2020 Jul. PMID 32054343
  4. EFTUD2 gene deficiency disrupts osteoblast maturation and inhibits chondrocyte differentiation via activation of the p53 signaling pathway. Wu J, et al. Hum Genomics, 2019 Dec 5. PMID 31806011, Free PMC Article
  5. Disruption of apoptosis pathways involved in zebrafish gonad differentiation by 17α-ethinylestradiol and fadrozole exposures. Luzio A, et al. Aquat Toxicol, 2016 Aug. PMID 27337697

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables tumor necrosis factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in activation-induced cell death of T cells IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in extrinsic apoptotic signaling pathway in absence of ligand IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in motor neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in necroptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within notochord development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within notochord development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of stress-activated MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CD95 death-inducing signaling complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily member 26
Names
Fas (TNF receptor superfamily, member 6)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    23619302..23631827 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467407.1 → XP_021323082.1  tumor necrosis factor receptor superfamily member 6

    UniProtKB/TrEMBL
    A0A8M9P0K2, F1QG24
    Related
    ENSDARP00000074016.4, ENSDART00000079563.6
    Conserved Domains (2) summary
    cd08316
    Location:200 → 292
    Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
    cd13423
    Location:28 → 129
    TNFRSF6_teleost; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6) in teleosts; also known as fas cell surface death receptor (FasR)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395331.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    224749..234884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_685355.7 → XP_690447.5  tumor necrosis factor receptor superfamily member 26

    UniProtKB/TrEMBL
    A0A8N7UR03
    Conserved Domains (2) summary
    cd08316
    Location:201 → 293
    Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
    cd13423
    Location:28 → 129
    TNFRSF6_teleost; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6) in teleosts; also known as fas cell surface death receptor (FasR)
Nucleotide Protein Strain
Heading Accession and Version

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