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PSAPL1 prosaposin like 1 (gene/pseudogene) [ Homo sapiens (human) ]

Gene ID: 768239, updated on 2-Oct-2018

Summary

Official Symbol
PSAPL1provided by HGNC
Official Full Name
prosaposin like 1 (gene/pseudogene)provided by HGNC
Primary source
HGNC:HGNC:33131
See related
Ensembl:ENSG00000178597 Vega:OTTHUMG00000160006
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein that is related to the glycoprotein prosaposin. Based on sequence similarity between the encoded protein and prosaposin, it is predicted that the encoded protein is a preproprotein that is proteolytically processed to generate multiple protein products. These predicted products include saposins A-like, B-like, C-like, and D-like, which may play a role in the lysosomal degradation of sphingolipids. [provided by RefSeq, Jul 2015]
Orthologs

Genomic context

See PSAPL1 in Genome Data Viewer
Location:
4p16.1
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (7430294..7434973, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (7432021..7436700, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene sortilin related VPS10 domain containing receptor 2 Neighboring gene transfer RNA suppressor (TTA) 3-1 Neighboring gene microRNA 4798 Neighboring gene microRNA 4274 Neighboring gene uncharacterized LOC107986258

Genomic regions, transcripts, and products

Pathways from BioSystems

  • Lysosome, organism-specific biosystem (from KEGG)
    Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
  • Lysosome, conserved biosystem (from KEGG)
    Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...

General gene information

Homology

Clone Names

  • FLJ40379

Gene Ontology Provided by GOA

Process Evidence Code Pubs
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epithelial cell differentiation involved in prostate gland development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prostate gland growth IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
proactivator polypeptide-like 1
Names
prosaposin-like 1
prosaposin-like protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085382.1NP_001078851.1  proactivator polypeptide-like 1 preproprotein

    See identical proteins and their annotated locations for NP_001078851.1

    Status: REVIEWED

    Source sequence(s)
    BC063708, DQ991252
    Consensus CDS
    CCDS47009.1
    UniProtKB/Swiss-Prot
    Q6NUJ1
    Related
    ENSP00000317445.4, OTTHUMP00000217346, ENST00000319098.6, OTTHUMT00000358859
    Conserved Domains (5) summary
    smart00741
    Location:293366
    SapB; Saposin (B) Domains
    pfam02199
    Location:479509
    SapA; Saposin A-type domain
    pfam03489
    Location:438469
    SapB_2; Saposin-like type B, region 2
    pfam05184
    Location:294328
    SapB_1; Saposin-like type B, region 1
    cl02494
    Location:2255
    SapA; Saposin A-type domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    7430294..7434973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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