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pdpk1a 3-phosphoinositide dependent protein kinase 1a [ Danio rerio (zebrafish) ]

Gene ID: 768202, updated on 2-Nov-2024

Summary

Official Symbol
pdpk1aprovided by ZNC
Official Full Name
3-phosphoinositide dependent protein kinase 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-061013-109
See related
Ensembl:ENSDARG00000062304 AllianceGenome:ZFIN:ZDB-GENE-061013-109
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7158209; zgc:153787
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human PDPK1 (3-phosphoinositide dependent protein kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See pdpk1a in Genome Data Viewer
Location:
chromosome: 3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (45285545..45308447, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (47333752..47346153, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 31 Neighboring gene potassium channel tetramerization domain containing 5a Neighboring gene interleukin 21 receptor, tandem duplicate 2 Neighboring gene uncharacterized LOC137490142

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
3-phosphoinositide-dependent protein kinase 1a
NP_001070812.1
XP_068073765.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077344.1NP_001070812.1  3-phosphoinositide-dependent protein kinase 1a precursor

    See identical proteins and their annotated locations for NP_001070812.1

    Status: PROVISIONAL

    Source sequence(s)
    BC124736
    UniProtKB/TrEMBL
    Q08BG3
    Related
    ENSDARP00000093021.3, ENSDART00000102245.5
    Conserved Domains (3) summary
    smart00220
    Location:77324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01262
    Location:429531
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cd05581
    Location:75337
    STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    45285545..45308447 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068217664.1XP_068073765.1  3-phosphoinositide-dependent protein kinase 1a isoform X1

    Related
    ENSDARP00000129062.1, ENSDART00000155324.3