anapc11 APC11 anaphase promoting complex subunit 11 homolog (yeast) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: anapc11provided by ZNC
Official Full Name: APC11 anaphase promoting complex subunit 11 homolog (yeast)provided by ZNC
Primary source: ZFIN:ZDB-GENE-061013-383
See related: Ensembl:ENSDARG00000102531 AllianceGenome:ZFIN:ZDB-GENE-061013-383
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:153671; si:dkey-237i9.4
Summary: Predicted to enable cullin family protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of mitotic metaphase/anaphase transition; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within anaphase-promoting complex-dependent catabolic process and cell division. Predicted to be part of anaphase-promoting complex. Predicted to be active in nucleus. Orthologous to human ANAPC11 (anaphase promoting complex subunit 11). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	6	NC_133181.1 (24266280..24272044, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (18245072..18250838, complement)

Chromosome 6 - NC_133181.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cullin family protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables cullin family protein binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anaphase-promoting complex-dependent catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic metaphase/anaphase transition	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	IBA Inferred from Biological aspect of Ancestor more info
part_of anaphase-promoting complex	IEA Inferred from Electronic Annotation more info
part_of cullin-RING ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: anaphase-promoting complex subunit 11

Names: anaphase promoting complex subunit 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098480.1 → NP_001091950.1 anaphase-promoting complex subunit 11

See identical proteins and their annotated locations for NP_001091950.1

Status: PROVISIONAL

Source sequence(s)

BC124716

UniProtKB/TrEMBL

A0A8M1NDB9, Q08BH9

Related

ENSDARP00000130416.1, ENSDART00000159486.2

Conserved Domains (2) summary

pfam12678
Location:2 → 77

zf-rbx1; RING-H2 zinc finger

cl17238
Location:1 → 84

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

NC_133181.1 Reference GRCz12tu Primary Assembly

Range

24266280..24272044 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005166196.5 → XP_005166253.1 anaphase-promoting complex subunit 11 isoform X1

UniProtKB/TrEMBL

A0A8M2BDS3

Conserved Domains (2) summary

pfam12678
Location:2 → 77

zf-rbx1; RING-H2 zinc finger

cl17238
Location:1 → 84

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...