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foxo1a forkhead box O1 a [ Danio rerio (zebrafish) ]

Gene ID: 768121, updated on 2-Nov-2024

Summary

Official Symbol
foxo1aprovided by ZNC
Official Full Name
forkhead box O1 aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-061013-59
See related
Ensembl:ENSDARG00000099555 AllianceGenome:ZFIN:ZDB-GENE-061013-59
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
foxo1; FoxO1a.1; zgc:153388
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within with a positive effect on gluconeogenesis. Acts upstream of or within several processes, including lymph vessel development; smooth muscle cell proliferation; and smooth muscle tissue development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in digestive system; head mesenchyme; pericardial region; pharyngeal arch; and skeletal muscle. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human FOXO1 (forkhead box O1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See foxo1a in Genome Data Viewer
Location:
chromosome: 15
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (3284421..3379044)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (3296393..3388756)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 15a Neighboring gene stomatin (EPB72)-like 3a Neighboring gene component of oligomeric golgi complex 6 Neighboring gene lipoma HMGIC fusion partner-like

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
forkhead box protein O1-A
Names
fox family transcription factor FoxO1a.1
foxhead box protein O1-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077257.2NP_001070725.2  forkhead box protein O1-A

    See identical proteins and their annotated locations for NP_001070725.2

    Status: PROVISIONAL

    Source sequence(s)
    EF421424
    UniProtKB/Swiss-Prot
    A3RK74, F1RBQ1, F8W360
    Related
    ENSDARP00000155088.1, ENSDART00000179778.1
    Conserved Domains (3) summary
    cd00059
    Location:134214
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16675
    Location:411480
    FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2
    pfam16676
    Location:593631
    FOXO-TAD; Transactivation domain of FOXO protein family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    3284421..3379044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009291427.4XP_009289702.1  forkhead box protein O1-A isoform X1

    See identical proteins and their annotated locations for XP_009289702.1

    UniProtKB/Swiss-Prot
    A3RK74, F1RBQ1, F8W360
    Related
    ENSDARP00000134884.1, ENSDART00000171723.3
    Conserved Domains (3) summary
    cd00059
    Location:134214
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16675
    Location:411480
    FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2
    pfam16676
    Location:593631
    FOXO-TAD; Transactivation domain of FOXO protein family