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Tbc1d9b TBC1 domain family, member 9B [ Mus musculus (house mouse) ]

Gene ID: 76795, updated on 5-Mar-2024

Summary

Official Symbol
Tbc1d9bprovided by MGI
Official Full Name
TBC1 domain family, member 9Bprovided by MGI
Primary source
MGI:MGI:1924045
See related
Ensembl:ENSMUSG00000036644 AllianceGenome:MGI:1924045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human TBC1D9B (TBC1 domain family member 9B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 62.4), cortex adult (RPKM 36.7) and 28 other tissues See more
Orthologs
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Genomic context

See Tbc1d9b in Genome Data Viewer
Location:
11 B1.3; 11 30.28 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50021891..50063612)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50131059..50172785)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 130 Neighboring gene microRNA 340 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene predicted gene, 53700 Neighboring gene STARR-positive B cell enhancer ABC_E1823 Neighboring gene MRN complex interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E6977 Neighboring gene STARR-seq mESC enhancer starr_29389 Neighboring gene sequestosome 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • 2700008N14Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
TBC1 domain family member 9B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290759.1NP_001277688.1  TBC1 domain family member 9B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK049999, BC065130, BY207144
    UniProtKB/Swiss-Prot
    Q5SVR0
    Conserved Domains (4) summary
    smart00054
    Location:886911
    EFh; EF-hand, calcium binding motif
    smart00164
    Location:506716
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd13354
    Location:299394
    PH-GRAM2_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2
    cd13351
    Location:153251
    PH-GRAM1_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1
  2. NM_001290760.1NP_001277689.1  TBC1 domain family member 9B isoform 1

    See identical proteins and their annotated locations for NP_001277689.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK049999, BC065130, BY207144
    Consensus CDS
    CCDS70175.1
    UniProtKB/Swiss-Prot
    Q3UGF5, Q5SVR0, Q6A019, Q6P1G9, Q6PDP2, Q80ZU6, Q8C7K9, Q8CBR7, Q8CCW2, Q9CSQ2
    Related
    ENSMUSP00000098828.5, ENSMUST00000101270.5
    Conserved Domains (5) summary
    smart00054
    Location:887912
    EFh; EF-hand, calcium binding motif
    smart00164
    Location:506716
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd13354
    Location:299394
    PH-GRAM2_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2
    cd13351
    Location:153251
    PH-GRAM1_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1
    cl08302
    Location:856907
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  3. NM_029745.2NP_084021.2  TBC1 domain family member 9B isoform 3

    See identical proteins and their annotated locations for NP_084021.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the central coding region but maintains reading frame, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AK035457, BC058596, BY207144
    Consensus CDS
    CCDS36146.1
    UniProtKB/Swiss-Prot
    Q5SVR0
    Related
    ENSMUSP00000090825.7, ENSMUST00000093138.13
    Conserved Domains (5) summary
    smart00054
    Location:887912
    EFh; EF-hand, calcium binding motif
    smart00164
    Location:506716
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd13354
    Location:299394
    PH-GRAM2_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2
    cd13351
    Location:153251
    PH-GRAM1_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1
    cl08302
    Location:856907
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    50021891..50063612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157082.1XP_036012975.1  TBC1 domain family member 9B isoform X2

    Conserved Domains (4) summary
    smart00054
    Location:887912
    EFh; EF-hand, calcium binding motif
    smart00164
    Location:506716
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd13354
    Location:299394
    PH-GRAM2_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2
    cd13351
    Location:153251
    PH-GRAM1_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1
  2. XM_006534458.5XP_006534521.1  TBC1 domain family member 9B isoform X1

    Conserved Domains (4) summary
    smart00054
    Location:887912
    EFh; EF-hand, calcium binding motif
    smart00164
    Location:506716
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd13354
    Location:299394
    PH-GRAM2_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2
    cd13351
    Location:153251
    PH-GRAM1_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1
  3. XM_036157083.1XP_036012976.1  TBC1 domain family member 9B isoform X3

    Conserved Domains (3) summary
    smart00054
    Location:565590
    EFh; EF-hand, calcium binding motif
    smart00164
    Location:184394
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cl17171
    Location:172
    PH-like; Pleckstrin homology-like domain

RNA

  1. XR_388552.5 RNA Sequence

  2. XR_388553.5 RNA Sequence

  3. XR_001780074.3 RNA Sequence

  4. XR_001780075.3 RNA Sequence