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DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease [ Bos taurus (domestic cattle) ]

Gene ID: 767887, updated on 4-Oct-2024

Summary

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Official Symbol
DIS3provided by VGNC
Official Full Name
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonucleaseprovided by VGNC
Primary source
VGNC:VGNC:28072
See related
BGD:BT13732; Ensembl:ENSBTAG00000019889
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See DIS3 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 12 NC_037339.1 (47507571..47532675, complement)

Chromosome 12 - NC_037339.1Genomic Context describing neighboring genes Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene mitotic spindle organizing protein 1 Neighboring gene BORA aurora kinase A activator Neighboring gene transfer RNA serine (anticodon GGA) Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene KLF transcription factor 5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037339.1 Chromosome 12 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in rRNA catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of cytoplasmic exosome (RNase complex) IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of nuclear exosome (RNase complex) IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
exosome complex exonuclease RRP44
Names
DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
DIS3 mitotic control homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037339.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    47507571..47532675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025000110.2 → XP_024855878.1  exosome complex exonuclease RRP44 isoform X1

    UniProtKB/TrEMBL
    A0AAA9RXX8, F1N1R4
    Related
    ENSBTAP00000026500.6, ENSBTAT00000026500.7
    Conserved Domains (2) summary
    cd09862
    Location:9 → 197
    PIN_Rrp44; PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
    COG0557
    Location:205 → 930
    VacB; Exoribonuclease R [Transcription]

  2. XM_025000117.2 → XP_024855885.1  exosome complex exonuclease RRP44 isoform X3

    UniProtKB/TrEMBL
    A0AAA9RXX8
    Related
    ENSBTAP00000078393.1, ENSBTAT00000102041.1
    Conserved Domains (2) summary
    COG0557
    Location:176 → 901
    VacB; Exoribonuclease R [Transcription]
    cl14812
    Location:9 → 168
    PIN_SF; PIN (PilT N terminus) domain: Superfamily

  3. XM_025000116.2 → XP_024855884.1  exosome complex exonuclease RRP44 isoform X2

    UniProtKB/TrEMBL
    A0AAA9RXX8
    Conserved Domains (2) summary
    COG0557
    Location:43 → 768
    VacB; Exoribonuclease R [Transcription]
    cl14812
    Location:8 → 35
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
Nucleotide Protein Strain
Heading Accession and Version

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