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C1S complement C1s [ Bos taurus (cattle) ]

Gene ID: 767827, updated on 12-Oct-2019

Summary

Official Symbol
C1Sprovided by VGNC
Official Full Name
complement C1sprovided by VGNC
Primary source
VGNC:VGNC:26630
See related
BGD:BT22240; Ensembl:ENSBTAG00000004840
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs

Genomic context

See C1S in Genome Data Viewer
Location:
chromosome: 5
Exon count:
12
Annotation release Status Assembly Chr Location
106 current ARS-UCD1.2 (GCF_002263795.1) 5 NC_037332.1 (103407687..103418871, complement)
105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 5 AC_000162.1 (103768065..103779250, complement)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101902570 Neighboring gene uncharacterized LOC112446757 Neighboring gene complement C1r Neighboring gene lysophosphatidylcholine acyltransferase 3 Neighboring gene small nucleolar RNA U89 Neighboring gene EMG1 N1-specific pseudouridine methyltransferase Neighboring gene prohibitin 2

Genomic regions, transcripts, and products

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC139966

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
complement C1s subcomponent
Names
C1 esterase
complement component 1 subcomponent s
complement component 1, s subcomponent
NP_001070018.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076550.1NP_001070018.1  complement C1s subcomponent precursor

    See identical proteins and their annotated locations for NP_001070018.1

    Status: PROVISIONAL

    Source sequence(s)
    BC119956
    UniProtKB/Swiss-Prot
    Q0VCX1
    Related
    ENSBTAP00000006358.4, ENSBTAT00000006358.5
    Conserved Domains (6) summary
    cd00033
    Location:365428
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:443682
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:24135
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:444685
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam14670
    Location:149177
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00049
    Location:181293
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD1.2 Primary Assembly

    Range
    103407687..103418871 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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