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ZNF124 zinc finger protein 124 [ Homo sapiens (human) ]

Gene ID: 7678, updated on 21-Dec-2019

Summary

Official Symbol
ZNF124provided by HGNC
Official Full Name
zinc finger protein 124provided by HGNC
Primary source
HGNC:HGNC:12907
See related
Ensembl:ENSG00000196418 MIM:194631
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZK7; HZF16; HZF-16
Summary
This gene encodes a protein with an amino-terminal KRAB-A box and multiple repeated Kruppel-type (C2H2) zinc finger motifs at its carboxy terminus. The encoded protein may function as a transcription factor. Expression of this gene is increased after vascular endothelial growth factor (VEGF) stimulation in human leukemia cell lines and results in inhibition of apoptotic cell death induced by irradiation or exposure to etoposide. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in colon (RPKM 1.3), small intestine (RPKM 1.0) and 25 other tissues See more
Orthologs

Genomic context

See ZNF124 in Genome Data Viewer
Location:
1q44
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (247121975..247172379, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (247285277..247335529, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chromosome 1 open reading frame 229 Neighboring gene fibroblast growth factor receptor 3 pseudogene 6 Neighboring gene peroxisomal biogenesis factor 5 pseudogene Neighboring gene vomeronasal 1 receptor 16 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 124 (ZNF124) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117046

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 124
Names
zinc finger protein HZF-16

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029824.1 RefSeqGene

    Range
    5000..55042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243740.2NP_001230669.1  zinc finger protein 124 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon and contains an alternate 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK054647, BC032514, DA610013, DA911997
    Consensus CDS
    CCDS58067.1
    UniProtKB/Swiss-Prot
    Q15973
    Related
    ENSP00000462445.1, ENST00000472531.5
    Conserved Domains (2) summary
    smart00349
    Location:1355
    KRAB; krueppel associated box
    pfam01352
    Location:1352
    KRAB; KRAB box
  2. NM_001297567.1NP_001284496.1  zinc finger protein 124 isoform 3

    See identical proteins and their annotated locations for NP_001284496.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon and contains an alternate 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL390728, BC013605, DA911997
    Consensus CDS
    CCDS76278.1
    UniProtKB/TrEMBL
    J3QKQ6
    Related
    ENSP00000463191.1, ENST00000491356.5
    Conserved Domains (1) summary
    pfam01352
    Location:1253
    KRAB; KRAB box
  3. NM_001297568.1NP_001284497.1  zinc finger protein 124 isoform 4

    See identical proteins and their annotated locations for NP_001284497.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (4) is longer than isoform 1.
    Source sequence(s)
    AK054647, AL390728, BC096351, BU607971, DA911997
    Consensus CDS
    CCDS73057.1
    UniProtKB/Swiss-Prot
    Q15973
    Related
    ENSP00000440365.2, ENST00000543802.2
    Conserved Domains (3) summary
    COG5048
    Location:176338
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:180200
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1253
    KRAB; KRAB box
  4. NM_001297569.1NP_001284498.1  zinc finger protein 124 isoform 5

    See identical proteins and their annotated locations for NP_001284498.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (5) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK054647, AL390728, BU607971, DA911997, DN993107
    UniProtKB/Swiss-Prot
    Q15973
    Conserved Domains (2) summary
    smart00349
    Location:1355
    KRAB; krueppel associated box
    pfam01352
    Location:1352
    KRAB; KRAB box
  5. NM_003431.4NP_003422.2  zinc finger protein 124 isoform 1

    See identical proteins and their annotated locations for NP_003422.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL390728
    Consensus CDS
    CCDS31089.1
    UniProtKB/Swiss-Prot
    Q15973
    Related
    ENSP00000340749.6, ENST00000340684.10
    Conserved Domains (3) summary
    COG5048
    Location:114276
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:118138
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1253
    KRAB; KRAB box

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    247121975..247172379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273257.4XP_005273314.1  zinc finger protein 124 isoform X3

    Conserved Domains (3) summary
    COG5048
    Location:73235
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:7797
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:89114
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011544272.3XP_011542574.1  zinc finger protein 124 isoform X1

    Conserved Domains (5) summary
    smart00349
    Location:547
    KRAB; krueppel associated box
    COG5048
    Location:168330
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:172192
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:544
    KRAB; KRAB box
    pfam13465
    Location:184209
    zf-H2C2_2; Zinc-finger double domain
  3. XM_006711813.3XP_006711876.1  zinc finger protein 124 isoform X2

    See identical proteins and their annotated locations for XP_006711876.1

    Conserved Domains (3) summary
    COG5048
    Location:135297
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:151176
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_001737398.2 RNA Sequence

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