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zgc:152891 zgc:152891 [ Danio rerio (zebrafish) ]

Gene ID: 767741, updated on 9-Dec-2024

Summary

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Official Symbol
zgc:152891provided by ZNC
Official Full Name
zgc:152891provided by ZNC
Primary source
ZFIN:ZDB-GENE-061013-229
See related
Ensembl:ENSDARG00000016789 AllianceGenome:ZFIN:ZDB-GENE-061013-229
Gene type
protein coding
RefSeq status
PREDICTED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
alox12b; wu:fi89d03; zgc:153926
Summary
Predicted to enable oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Predicted to be involved in arachidonate metabolic process; lipid oxidation; and lipoxygenase pathway. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1; autosomal recessive congenital ichthyosis 2; and autosomal recessive congenital ichthyosis 3. Orthologous to human ALOX12B (arachidonate 12-lipoxygenase, 12R type); ALOX15B (arachidonate 15-lipoxygenase type B); and ALOXE3 (arachidonate epidermal lipoxygenase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See zgc:152891 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (31197295..31226037, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (31160600..31189342, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene transfer RNA aspartic acid (anticodon GUC) Neighboring gene transfer RNA aspartic acid (anticodon GUC) Neighboring gene transfer RNA glutamic acid (anticodon CUC) Neighboring gene transfer RNA tryptophan (anticodon CCA)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The lipoxygenase pathway in zebrafish. Expression and characterization of zebrafish ALOX5 and comparison with its human ortholog. Adel S, et al. Biochim Biophys Acta, 2016 Jan. PMID 26456699
  2. Glucocorticoid-Induced Attenuation of the Inflammatory Response in Zebrafish. Chatzopoulou A, et al. Endocrinology, 2016 Jul. PMID 27219276
  3. Transcriptional profiles and copper stress responses in zebrafish cox17 mutants. Sun H, et al. Environ Pollut, 2020 Jan. PMID 31662245
  4. Functional Characterization and Expression Analyses Show Differential Roles of Maternal and Zygotic Dgcr8 in Early Embryonic Development. Zhu Z, et al. Front Genet, 2020. PMID 32296464, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC152891, MGC153926

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables linoleate 13S-lipoxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in arachidonate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in lipoxygenase pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC767741
Names
ALOX4b
NP_001070178.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076710.2 → NP_001070178.2  uncharacterized protein LOC767741

    Status: PREDICTED

    Source sequence(s)
    BC124493
    UniProtKB/TrEMBL
    A0A8M1N9Y2, B2GSC9, F1QKM3, Q08BZ2
    Related
    ENSDARP00000023401.8, ENSDART00000011572.9
    Conserved Domains (2) summary
    pfam00305
    Location:220 → 647
    Lipoxygenase; Lipoxygenase
    pfam01477
    Location:4 → 107
    PLAT; PLAT/LH2 domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    31197295..31226037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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