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Creld2 cysteine-rich with EGF-like domains 2 [ Mus musculus (house mouse) ]

Gene ID: 76737, updated on 12-May-2024

Summary

Official Symbol
Creld2provided by MGI
Official Full Name
cysteine-rich with EGF-like domains 2provided by MGI
Primary source
MGI:MGI:1923987
See related
Ensembl:ENSMUSG00000023272 AllianceGenome:MGI:1923987
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730592L21Rik
Summary
Predicted to enable calcium ion binding activity and protein disulfide isomerase activity. Predicted to be an extracellular matrix structural constituent. Located in Golgi apparatus; endoplasmic reticulum; and extracellular space. Is expressed in several structures, including alimentary system; bone; brain; genitourinary system; and respiratory system. Orthologous to human CRELD2 (cysteine rich with EGF like domains 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 146.2), ovary adult (RPKM 63.5) and 25 other tissues See more
Orthologs
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Genomic context

See Creld2 in Genome Data Viewer
Location:
15 E3; 15 44.31 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (88703849..88710884)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (88819646..88826681)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5507 Neighboring gene zinc finger, BED type containing 4 Neighboring gene STARR-seq mESC enhancer starr_39444 Neighboring gene ALG12 alpha-1,6-mannosyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E391 Neighboring gene predicted gene, 23144 Neighboring gene STARR-positive B cell enhancer ABC_E4145 Neighboring gene predicted gene, 33049 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:88692779-88692962 Neighboring gene proviral integration site 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein disulfide isomerase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein disulfide isomerase Creld2
Names
cysteine-rich with EGF-like domain protein 2
NP_083996.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029720.2NP_083996.1  protein disulfide isomerase Creld2 precursor

    See identical proteins and their annotated locations for NP_083996.1

    Status: PROVISIONAL

    Source sequence(s)
    AK017880
    Consensus CDS
    CCDS27733.1
    UniProtKB/Swiss-Prot
    Q9CYA0
    Related
    ENSMUSP00000024042.4, ENSMUST00000024042.5
    Conserved Domains (3) summary
    smart00261
    Location:253288
    FU; Furin-like repeats
    cd00064
    Location:196246
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    cl00057
    Location:286326
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    88703849..88710884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)