U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF222 zinc finger protein 222 [ Homo sapiens (human) ]

Gene ID: 7673, updated on 1-Mar-2024

Summary

Official Symbol
ZNF222provided by HGNC
Official Full Name
zinc finger protein 222provided by HGNC
Primary source
HGNC:HGNC:13015
See related
Ensembl:ENSG00000159885 MIM:617357; AllianceGenome:HGNC:13015
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 3.6), urinary bladder (RPKM 1.6) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ZNF222 in Genome Data Viewer
Location:
19q13.31
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44025379..44033110)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46848287..46856014)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44529531..44537263)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14748 Neighboring gene zinc finger protein 230 Neighboring gene ZNF222 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14750 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44555855-44556356 Neighboring gene zinc finger protein 223 Neighboring gene zinc finger protein 284 Neighboring gene RNA, U6 small nuclear 902, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001129996.2NP_001123468.1  zinc finger protein 222 isoform 1

    See identical proteins and their annotated locations for NP_001123468.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    BC030261, DB185422
    Consensus CDS
    CCDS46098.1
    UniProtKB/Swiss-Prot
    Q9UK12
    Related
    ENSP00000375822.2, ENST00000391960.4
    Conserved Domains (5) summary
    smart00349
    Location:1776
    KRAB; krueppel associated box
    COG5048
    Location:183315
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:187207
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1756
    KRAB; KRAB box
    pfam13465
    Location:284306
    zf-H2C2_2; Zinc-finger double domain
  2. NM_013360.3NP_037492.2  zinc finger protein 222 isoform 2

    See identical proteins and their annotated locations for NP_037492.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2 which is 40 aa shorter than isoform 1.
    Source sequence(s)
    AF187988, BC030261
    Consensus CDS
    CCDS33045.1
    UniProtKB/Swiss-Prot
    G5E9B9, Q8N6G7, Q9P1U5, Q9UK12
    Related
    ENSP00000187879.6, ENST00000187879.12
    Conserved Domains (4) summary
    smart00349
    Location:853
    KRAB; krueppel associated box
    sd00017
    Location:147167
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:244266
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    44025379..44033110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259208.4XP_005259265.1  zinc finger protein 222 isoform X1

    Conserved Domains (4) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:275297
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017027237.2XP_016882726.1  zinc finger protein 222 isoform X3

  3. XM_005259209.4XP_005259266.1  zinc finger protein 222 isoform X2

    Conserved Domains (4) summary
    smart00349
    Location:1762
    KRAB; krueppel associated box
    sd00017
    Location:156176
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1756
    KRAB; KRAB box
    pfam13465
    Location:253275
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    46848287..46856014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321998.1XP_054177973.1  zinc finger protein 222 isoform X1

  2. XM_054322000.1XP_054177975.1  zinc finger protein 222 isoform X3

  3. XM_054321999.1XP_054177974.1  zinc finger protein 222 isoform X2