U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Arfrp1 ADP-ribosylation factor related protein 1 [ Mus musculus (house mouse) ]

Gene ID: 76688, updated on 18-Apr-2024

Summary

Official Symbol
Arfrp1provided by MGI
Official Full Name
ADP-ribosylation factor related protein 1provided by MGI
Primary source
MGI:MGI:1923938
See related
Ensembl:ENSMUSG00000038671 AllianceGenome:MGI:1923938
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500006I01Rik
Summary
The gene encodes a membrane-associated GTPase that is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) genes. It plays an essential role in Golgi function controlling recruitment of GRIP domain proteins and ARL1 to the trans-Golgi and trans-Golgi to plasma membrane trafficking of cell surface proteins such as E-cadherin. Deletion of this gene in mice leads to embryonic lethality during early gastrulation, which is at least partly caused by the disruption of E-cadherin trafficking to the cell surface and therefore lack of sufficient cell-cell adhesion in the embryo. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in CNS E14 (RPKM 16.3), CNS E18 (RPKM 14.7) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
2 H4; 2 103.63 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180999483..181007197, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181357690..181365404, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10172 Neighboring gene STARR-seq mESC enhancer starr_06749 Neighboring gene stathmin-like 3 Neighboring gene STARR-seq mESC enhancer starr_06750 Neighboring gene STARR-seq mESC enhancer starr_06751 Neighboring gene regulator of telomere elongation helicase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4532 Neighboring gene STARR-positive B cell enhancer ABC_E11178 Neighboring gene zinc finger, CCCH-type with G patch domain Neighboring gene zinc finger and BTB domain containing 46 Neighboring gene Slc2a4 regulator, pseudogene Neighboring gene Lck interacting transmembrane adaptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC6837

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in Golgi to plasma membrane protein transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ADP-ribosylation factor-related protein 1
Names
ARF-related protein 1
NP_001159463.1
NP_001159464.1
NP_001159467.1
NP_083978.3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165991.1NP_001159463.1  ADP-ribosylation factor-related protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001159463.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AK005174, AL928965, BB770913, BC046786
    Consensus CDS
    CCDS17209.1
    UniProtKB/Swiss-Prot
    Q8BXL7
    Related
    ENSMUSP00000104436.2, ENSMUST00000108808.8
    Conserved Domains (1) summary
    cd04160
    Location:19186
    Arfrp1; Arf-related protein 1 (Arfrp1)
  2. NM_001165992.1NP_001159464.1  ADP-ribosylation factor-related protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001159464.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AL928965
    Consensus CDS
    CCDS17209.1
    UniProtKB/Swiss-Prot
    Q8BXL7
    Conserved Domains (1) summary
    cd04160
    Location:19186
    Arfrp1; Arf-related protein 1 (Arfrp1)
  3. NM_001165995.1NP_001159467.1  ADP-ribosylation factor-related protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001159467.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 5' region that results in a distinct 5' UTR and causes translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL928965
    Consensus CDS
    CCDS50853.1
    UniProtKB/TrEMBL
    E9PZK7
    Related
    ENSMUSP00000126387.2, ENSMUST00000170190.8
    Conserved Domains (1) summary
    cd04160
    Location:1139
    Arfrp1; Arf-related protein 1 (Arfrp1)
  4. NM_029702.4NP_083978.3  ADP-ribosylation factor-related protein 1 isoform 1

    See identical proteins and their annotated locations for NP_083978.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AK005174, AL928965, BB770913, BC046786, CA539216
    Consensus CDS
    CCDS17209.1
    UniProtKB/Swiss-Prot
    Q8BXL7
    Related
    ENSMUSP00000122066.2, ENSMUST00000127988.8
    Conserved Domains (1) summary
    cd04160
    Location:19186
    Arfrp1; Arf-related protein 1 (Arfrp1)

RNA

  1. NR_028585.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL928965, BB770913, BC046786, CA539216
    Related
    ENSMUST00000185118.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    180999483..181007197 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003953743.2 RNA Sequence