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Spcs3 signal peptidase complex subunit 3 homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 76687, updated on 13-Oct-2022

Summary

Official Symbol
Spcs3provided by MGI
Official Full Name
signal peptidase complex subunit 3 homolog (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:1923937
See related
Ensembl:ENSMUSG00000054408 AllianceGenome:MGI:1923937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SPC22/23; 1810011E08Rik
Summary
Predicted to enable peptidase activity. Predicted to be involved in protein targeting to ER; signal peptide processing; and viral protein processing. Predicted to be located in endoplasmic reticulum. Predicted to be part of signal peptidase complex. Is expressed in alimentary system and liver. Orthologous to human SPCS3 (signal peptidase complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 14.6), liver E14 (RPKM 13.1) and 28 other tissues See more
Orthologs
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Genomic context

See Spcs3 in Genome Data Viewer
Location:
8; 8 B1.3
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (54973468..54983033, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (54520433..54529998, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein C12orf41 homolog Neighboring gene predicted gene, 33153 Neighboring gene vascular endothelial growth factor C Neighboring gene RIKEN cDNA 5330439A09 gene Neighboring gene ankyrin repeat and SOCs box-containing 5 Neighboring gene predicted gene, 46039

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal peptide processing ISO
Inferred from Sequence Orthology
more info
 
involved_in viral protein processing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of signal peptidase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
signal peptidase complex subunit 3
Names
SPase 22/23 kDa subunit
microsomal signal peptidase 22/23 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029701.1NP_083977.1  signal peptidase complex subunit 3

    See identical proteins and their annotated locations for NP_083977.1

    Status: VALIDATED

    Source sequence(s)
    AK007432, AK037878, BY012914, CO041079
    Consensus CDS
    CCDS57621.1
    UniProtKB/Swiss-Prot
    Q6ZWQ7, Q8C1D0
    UniProtKB/TrEMBL
    A0A6P5Q341, A0A8C6GGG9
    Related
    ENSMUSP00000136527.2, ENSMUST00000067476.9
    Conserved Domains (1) summary
    pfam04573
    Location:4173
    SPC22; Signal peptidase subunit

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    54973468..54983033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)