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Trim12a tripartite motif-containing 12A [ Mus musculus (house mouse) ]

Gene ID: 76681, updated on 24-Oct-2019

Summary

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Official Symbol
Trim12aprovided by MGI
Official Full Name
tripartite motif-containing 12Aprovided by MGI
Primary source
MGI:MGI:1923931
See related
Ensembl:ENSMUSG00000066258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trim12; 2310043C01Rik
Expression
Ubiquitous expression in bladder adult (RPKM 4.6), thymus adult (RPKM 3.8) and 27 other tissues See more

Genomic context

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See Trim12a in Genome Data Viewer
Location:
7; 7 E3
Exon count:
9
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (104299893..104315558, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (111448411..111464009, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene tripartite motif-containing 5 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene predicted gene 15133 Neighboring gene tripartite motif-containing protein 30-like Neighboring gene tripartite motif-containing 34B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Copy number variation influences gene expression and metabolic traits in mice. Orozco LD, et al. Hum Mol Genet, 2009 Nov 1. PMID 19648292, Free PMC Article
  2. Genetic mapping in mice identifies DMBT1 as a candidate modifier of mammary tumors and breast cancer risk. Blackburn AC, et al. Am J Pathol, 2007 Jun. PMID 17525270, Free PMC Article
  3. An expanded clade of rodent Trim5 genes. Tareen SU, et al. Virology, 2009 Mar 15. PMID 19147168, Free PMC Article
  4. Postnatal gene expression in the normal mouse cornea by SAGE. Norman B, et al. Invest Ophthalmol Vis Sci, 2004 Feb. PMID 14744882
  5. Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice. Boon AC, et al. J Virol, 2009 Oct. PMID 19706712, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Genotypes

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
  
ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
autophagy IEA
Inferred from Electronic Annotation
more info
  
biological_process ND
No biological Data available
more info
  
defense response to virus IEA
Inferred from Electronic Annotation
more info
  
innate immune response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tripartite motif-containing protein 12A
Names
tripartite motif protein 12
tripartite motif-containing 12
tripartite motif-containing protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368753.1 → NP_001355682.1  tripartite motif-containing protein 12A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC142110
    Conserved Domains (4) summary
    smart00336
    Location:96 → 132
    BBOX; B-Box-type zinc finger
    COG5432
    Location:6 → 112
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    pfam08317
    Location:132 → 209
    Spc7; Spc7 kinetochore protein
    cl17238
    Location:12 → 60
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. NM_001368754.1 → NP_001355683.1  tripartite motif-containing protein 12A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC142110
    Consensus CDS
    CCDS90296.1
    Related
    ENSMUSP00000065008.6, ENSMUST00000070943.6
    Conserved Domains (4) summary
    smart00336
    Location:96 → 132
    BBOX; B-Box-type zinc finger
    COG5432
    Location:6 → 112
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    pfam07888
    Location:128 → 251
    CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
    cl17238
    Location:12 → 60
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. NM_023835.2 → NP_076324.2  tripartite motif-containing protein 12A isoform 2

    See identical proteins and their annotated locations for NP_076324.2

    Status: VALIDATED

    Source sequence(s)
    AC142110, AK009769, DV553257
    Consensus CDS
    CCDS40067.1
    UniProtKB/Swiss-Prot
    Q99PQ1
    UniProtKB/TrEMBL
    A0A0R4J1B5
    Related
    ENSMUSP00000102452.2, ENSMUST00000106839.8
    Conserved Domains (2) summary
    smart00336
    Location:96 → 132
    BBOX; B-Box-type zinc finger
    cl17238
    Location:15 → 58
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p6 C57BL/6J

    Range
    104299893..104315558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312372.2 → XP_017167861.1  tripartite motif-containing protein 12A isoform X1

    UniProtKB/Swiss-Prot
    Q99PQ1
    UniProtKB/TrEMBL
    A0A0R4J1B5
    Conserved Domains (2) summary
    smart00336
    Location:96 → 132
    BBOX; B-Box-type zinc finger
    cl17238
    Location:15 → 58
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  2. XM_017312375.2 → XP_017167864.1  tripartite motif-containing protein 12A isoform X2

    UniProtKB/TrEMBL
    D3YVI1
    Related
    ENSMUSP00000102450.1, ENSMUST00000106837.7

  3. XM_030243081.1 → XP_030098941.1  tripartite motif-containing protein 12A isoform X1

  4. XM_030243080.1 → XP_030098940.1  tripartite motif-containing protein 12A isoform X1

  5. XM_017312373.2 → XP_017167862.1  tripartite motif-containing protein 12A isoform X1

    UniProtKB/Swiss-Prot
    Q99PQ1
    UniProtKB/TrEMBL
    A0A0R4J1B5
    Conserved Domains (2) summary
    smart00336
    Location:96 → 132
    BBOX; B-Box-type zinc finger
    cl17238
    Location:15 → 58
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  6. XM_030243082.1 → XP_030098942.1  tripartite motif-containing protein 12A isoform X1

  7. XM_030243083.1 → XP_030098943.1  tripartite motif-containing protein 12A isoform X3

RNA

  1. XR_003946578.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99PQ1.1 GenPept UniProtKB/Swiss-Prot:Q99PQ1

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