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Cfap70 cilia and flagella associated protein 70 [ Mus musculus (house mouse) ]

Gene ID: 76670, updated on 24-Sep-2025
Official Symbol
Cfap70provided by MGI
Official Full Name
cilia and flagella associated protein 70provided by MGI
Primary source
MGI:MGI:1923920
See related
Ensembl:ENSMUSG00000039543 AllianceGenome:MGI:1923920
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ttc18
Summary
Involved in cilium assembly and cilium movement. Acts upstream of or within several processes, including maintenance of cell number; single fertilization; and spermatid development. Located in axoneme and sperm flagellum. Is active in cytoplasm and manchette. Is expressed in lateral ventricle choroid plexus; metencephalon part of 4th ventricle choroid plexus; and olfactory epithelium. Used to study oligoasthenoteratozoospermia. Human ortholog(s) of this gene implicated in spermatogenic failure 41. Orthologous to human CFAP70 (cilia and flagella associated protein 70). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in testis adult (RPKM 20.3) and lung adult (RPKM 0.5) See more
Orthologs
human all
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See Cfap70 in Genome Data Viewer
Location:
14 A3; 14 11.53 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20444258..20502332, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20394190..20452264, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3105 Neighboring gene DnaJ heat shock protein family (Hsp40) member C9 Neighboring gene RIKEN cDNA 7330404K18 gene Neighboring gene mitochondrial ribosomal protein S16 Neighboring gene STARR-seq mESC enhancer starr_36110 Neighboring gene annexin A7 Neighboring gene MSS51 mitochondrial translational activator

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. CFAP70 is a solid and valuable target for the genetic diagnosis of oligo-astheno-teratozoospermia in infertile men. Jin HJ, et al. EBioMedicine, 2023 Jul. PMID 37352829, Free PMC Article
  2. CFAP70 Is a Novel Axoneme-Binding Protein That Localizes at the Base of the Outer Dynein Arm and Regulates Ciliary Motility. Shamoto N, et al. Cells, 2018 Aug 29. PMID 30158508, Free PMC Article
  3. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504
  4. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Homology

Clone Names

  • 5330402L21Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium movement IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cilium organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within homeostasis of number of cells IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within maintenance of cell number IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within manchette assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within single fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sperm flagellum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axoneme IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in manchette IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
part_of outer dynein arm ISO
Inferred from Sequence Orthology
more info
  
part_of outer dynein arm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
cilia- and flagella-associated protein 70
Names
TPR repeat protein 18
tetratricopeptide repeat domain 18
tetratricopeptide repeat protein 18

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163638.1 → NP_001157110.1  cilia- and flagella-associated protein 70 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AC121801
    Consensus CDS
    CCDS49411.1
    UniProtKB/TrEMBL
    E9Q7X8
    Related
    ENSMUSP00000022349.7, ENSMUST00000022349.14
    Conserved Domains (2) summary
    sd00006
    Location:1005 → 1031
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:1037 → 1099
    TPR_11; TPR repeat

  2. NM_001163639.1 → NP_001157111.1  cilia- and flagella-associated protein 70 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons and contains an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC121801
    Consensus CDS
    CCDS49412.1
    UniProtKB/TrEMBL
    D3Z1K9
    Related
    ENSMUSP00000022348.8, ENSMUST00000022348.15
    Conserved Domains (2) summary
    sd00006
    Location:978 → 1004
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:1010 → 1072
    TPR_11; TPR repeat

  3. NM_029698.1 → NP_083974.1  cilia- and flagella-associated protein 70 isoform 3

    See identical proteins and their annotated locations for NP_083974.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks one in-frame exon and contains an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is longer, compared to isoform 1.
    Source sequence(s)
    AC121801
    Consensus CDS
    CCDS49413.1
    UniProtKB/Swiss-Prot
    B7ZNG2, B7ZNG3, D3YVL2, D3Z1K9, E9Q7X8
    Related
    ENSMUSP00000056869.7, ENSMUST00000056073.14
    Conserved Domains (3) summary
    COG0457
    Location:950 → 1117
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    TIGR02917
    Location:702 → 1124
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:1022 → 1048
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    20444258..20502332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519684.1 → XP_006519747.1  cilia- and flagella-associated protein 70 isoform X1

    Conserved Domains (2) summary
    TIGR02917
    Location:647 → 1011
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:669 → 696
    TPR; TPR repeat [structural motif]

  2. XM_036158900.1 → XP_036014793.1  cilia- and flagella-associated protein 70 isoform X2

    Conserved Domains (2) summary
    COG0457
    Location:635 → 767
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:669 → 696
    TPR; TPR repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3YVL2.2 GenPept UniProtKB/Swiss-Prot:D3YVL2

Gene LinkOut

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