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Wdr38 WD repeat domain 38 [ Mus musculus (house mouse) ]

Gene ID: 76646, updated on 28-Feb-2023

Summary

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Official Symbol
Wdr38provided by MGI
Official Full Name
WD repeat domain 38provided by MGI
Primary source
MGI:MGI:1923896
See related
Ensembl:ENSMUSG00000035295 AllianceGenome:MGI:1923896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700123D08Rik
Summary
Acts upstream of or within hematopoietic progenitor cell differentiation. Orthologous to human WDR38 (WD repeat domain 38). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 33.3) and ovary adult (RPKM 2.4) See more
Orthologs
human all
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Genomic context

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See Wdr38 in Genome Data Viewer
Location:
2; 2 B
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (38888287..38891600)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (38998309..39001584)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39801 Neighboring gene predicted gene, 29985 Neighboring gene ribosomal protein L35 Neighboring gene actin related protein 2/3 complex, subunit 5-like Neighboring gene golgin A1 Neighboring gene predicted gene, 26127

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
  2. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
  3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
WD repeat-containing protein 38
Names
novel WD domain, G-beta repeat domain containing protein (1700123D08Rik)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029687.4 → NP_083963.1  WD repeat-containing protein 38

    See identical proteins and their annotated locations for NP_083963.1

    Status: VALIDATED

    Source sequence(s)
    AL844588
    Consensus CDS
    CCDS38119.1
    UniProtKB/Swiss-Prot
    Q9D994
    Related
    ENSMUSP00000108493.2, ENSMUST00000112872.2
    Conserved Domains (3) summary
    COG2319
    Location:18 → 300
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:25 → 300
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:31 → 66
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    38888287..38891600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162672.1 → XP_036018565.1  WD repeat-containing protein 38 isoform X1

    Conserved Domains (2) summary
    cd00200
    Location:63 → 294
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:66 → 102
    7WD40; WD40 repeat [structural motif]

  2. XM_036162673.1 → XP_036018566.1  WD repeat-containing protein 38 isoform X2

    Conserved Domains (2) summary
    cd00200
    Location:25 → 279
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:31 → 66
    7WD40; WD40 repeat [structural motif]

RNA

  1. XR_004940766.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D994.1 GenPept UniProtKB/Swiss-Prot:Q9D994

Gene LinkOut

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